JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB141775

CRANAD-2, Near-infrared Amyloid-beta fluorescent probe

Be the first to review this product! Submit a review

|

(1 Publication)

MW 410.3 Da, Purity >98%. Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more.

Key facts

CAS number

1193447-34-5

Purity

>98%

Form

Solid

form

Molecular weight

410.3 Da

Molecular formula

C<sub>2</sub><sub>3</sub>H<sub>2</sub><sub>5</sub>BF<sub>2</sub>N<sub>2</sub>O<sub>2</sub>

PubChem

90488972

Nature

Synthetic

Solubility

Soluble in DMSO to 5 mM (with warming)

Biochemical name

Cranad-2

Biological description

Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more

Canonical smiles

[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F

Isomeric smiles

[B-]1(OC(=C/C(=C/C=C2C=CC(=[N+](C)C)C=C2)/O1)/C=C/C3=CC=C(C=C3)N(C)C)(F)F

InChi

InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3

InChiKey

PVXQJYXODFZTBR-UHFFFAOYSA-N

IUPAC Name

[4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difluoro-1,3-dioxa-2-boranuidacyclohex-5-en-4-ylidene]ethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium

style
left-column

Complementary Products

Biochemicals

AB216983

MCAAD-3, Near-infrared probe for imaging of amyloid plaques

  • 0
  • 0
Biochemicals

AB120301

beta-Amyloid Peptide (1-42) (human)

Chemical Structure - beta-Amyloid Peptide (1-42) (human) (AB120301)

  • 5
  • 1
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Biochemicals

AB120479

beta-Amyloid Peptide (1-40) (human)

Chemical Structure - beta-Amyloid Peptide (1-40) (human) (AB120479)

  • 0
  • 0
style
left-column

Product details

This product is manufactured by BioVision, an Abcam company and was previously called 2699 CRANAD-2. 2699-25 is the same size as the 25 mg size of ab141775.
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in neuroscience 18:1325287 PubMed38406587

2024

The effect of human PBMCs immobilization on their Аβ42 aggregates-dependent proinflammatory state on a cellular model of Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Kateryna Kot,Yurii Kot,Rustam Kurbanov,Hanna Andriiash,Olena Tigunova,Yaroslav Blume,Sergiy Shulga
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com