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MW 410.3 Da, Purity >98%. Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more.

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Key facts

CAS number
1193447-34-5
Purity
> 98%
Form
Solid
Molecular weight
410.3 Da
Molecular formula
C23H25BF2N2O2
PubChem identifier
90488972
Nature
Synthetic

Target data

Recommended products

MW 410.3 Da, Purity >98%. Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more.

Key facts

Purity
> 98%
PubChem identifier
90488972
Solubility

Soluble in DMSO to 5 mM (with warming).

Biochemical name
Cranad-2
Biological description

Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more

Canonical SMILES
[B-]1(OC(=CC(=CC=C2C=CC(=[N+](C)C)C=C2)O1)C=CC3=CC=C(C=C3)N(C)C)(F)F
Isomeric SMILES
[B-]1(OC(=C/C(=C/C=C2C=CC(=[N+](C)C)C=C2)/O1)/C=C/C3=CC=C(C=C3)N(C)C)(F)F
InChI
InChI=1S/C23H25BF2N2O2/c1-27(2)20-11-5-18(6-12-20)9-15-22-17-23(30-24(25,26)29-22)16-10-19-7-13-21(14-8-19)28(3)4/h5-17H,1-4H3
InChIKey
PVXQJYXODFZTBR-UHFFFAOYSA-N
IUPAC name
[4-[(2Z)-2-[6-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-2,2-difluoro-1,3-dioxa-2-boranuidacyclohex-5-en-4-ylidene]ethylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark, Store under desiccating conditions

Notes

This product is manufactured by BioVision, an Abcam company and was previously called 2699 CRANAD-2. 2699-25 is the same size as the 25 mg size of ab141775.

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