MW 443.5 Da, Purity 97%. Potent inhibitor of PDGFR (Kd for alpha = 2.1 nM; beta = 3.2 nM) and FLT3 (Kd = 0.74 nM). Type I inhibitor that binds only the active kinase conformation. Active towards imatinib-resistance assciated PDGFR-alpha mutations (D842I, D842V, D842Y, DI842-843M, and deletion I843). Active against FLT3/ITD and FLY3/D835 mutatants. Over 100-fold selective for PDGFR versus c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
View Alternative Names
AP 4 A synthetase, CAM kinase II delta, CAMK 2, CAMK 2B, CAMK 2d, CAMK2G, CAMKA, CMT2D, CaM kinase II, CaM kinase II alpha, CaM kinase II beta, CaM kinase II gamma, CaM kinase II subunit alpha, CaMK-II subunit alpha, Calcium / calmodulin dependent protein kinase II delta, Calcium/calmodulin dependent protein kinase II gamma, Calcium/calmodulin-dependent protein kinase II-alpha, Calcium/calmodulin-dependent protein kinase type II subunit alpha, Camk2a, Charcot Marie Tooth neuropathy 2D, Charcot Marie Tooth neuropathy neuronal type D, DSMAV, Diadenosine tetraphosphate synthetase, EC 2.7.11.1, EC 6.1.1.14, GSD9C, Germinal center kinase like kinase, Germinal center kinase-related protein kinase, GlyRS, Glycine tRNA ligase, Glycyl tRNA synthetase, HMN5, KCC2A_HUMAN, KHS, Kinase homologous to SPS1/STE20, MAP4K3, MAPK/ERK kinase kinase kinase 3, MAPK/ERK kinase kinase kinase 5, MAPKKKK3, MEK kinase kinase 3, MEK kinase kinase 5, MEKKK 3, MEKKK 5, PHK gamma LT, PHK gamma T, PSK C3, Phosphorylase b kinase gamma catalytic chain testis/liver isoform, Phosphorylase b kinase gamma catalytic chain, liver/testis isoform, Phosphorylase kinase catalytic subunit gamma 2, Phosphorylase kinase gamma subunit 2, Phosphorylase kinase subunit gamma 2, Phosphorylase kinase, gamma 2 (testis), Phosphorylase kinase, gamma 2 (testis/liver), RAB8IPL1, Serine/threonine protein kinase PHKG2, calcium/calmodulin-dependent protein kinase II beta, mitogen-activated protein kinase kinase kinase kinase 3
- Chemical Structure
Lab
Chemical Structure - Crenolanib (CP-868596) (AB273385)
Chemical structure of Crenolanib (CP-868596), 670220-88-9
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
These proteins serve as significant modulators of cellular activities. CaMKII plays a role in calcium ion signaling and associates with L-type calcium channel complex enhancing signal transduction. PHKG2 regulates glycogen metabolism being part of a complex involved in glycogen breakdown. MAP4K5 and MAP4K3 function in stress-activated protein kinase pathways taking part in immune responses and cell apoptosis. GARS joins protein synthesis machinery by catalyzing the attachment of glycine to its corresponding transfer RNA.
Pathways
These proteins integrate into essential signaling and metabolic routes. CaMKII influences the calcium/calmodulin signaling pathway affecting brain functions and cardiac contractility relating closely to proteins like calmodulin and synapsin. PHKG2 fits into the glycogen degradation pathway interacting with partners such as phosphorylase kinase beta. MAP4K5 and MAP4K3 engage in the JNK signaling cascade essential for inflammatory response linking with MAPK and AP-1 transcription factors. GARS operates within the protein biosynthesis pathway connecting to elongation factors to ensure accurate amino acid incorporation.
Complementary Products
Primary Antibodies
AB248097
Anti-GARS antibody [EPR7157] - BSA and Azide free
RabMAb|Recombinant
![Western blot - Anti-GARS antibody [EPR7157] - BSA and Azide free (AB248097)](https://content.abcam.com/products/images/gars-antibody-epr7157-bsa-and-azide-free-ab248097--western-blot-img100979.jpg)
- 0
- 0
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com