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MW 411.33 g/mol, Purity >99%. Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.

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Key facts

Purity
> 99%
Form
Solid
Molecular weight
411.33 g/mol
Molecular formula
C18H22N6O.2HCl
Nature
Synthetic

Target data

Recommended products

MW 411.33 g/mol, Purity >99%. Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.

Key facts

Purity
> 99%
Solubility

Soluble in 1ml of water to give specified mM/ml concentration.

Biological description

Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.

Isomeric SMILES
CL.CL.CN1CC(CN1)C3CC(C2NC(NC[C@H](N)CC)CCN2)C(O)CC3
InChI
InChI=1S/C18H22N6O/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23)/t14-/m1/s1
InChIKey
SCJXQZZYGYLKJG-CQSZACIVSA-N
IUPAC name
2-[4-[[(2R)-2-Aminobutyl]amino]pyrimidin-2-yl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

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