MW 411.3 Da, Purity >99%. Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.
Also available in simple stock solutions (ab146740) - add 1 ml of water to get an exact, ready-to-use concentration.
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- Nature communications 8:15922017TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShin-Ichiroh Saitoh et. al.PubMed 29150602
- Cell reports 15:1728-422016An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMehran Najibi et. al.PubMed 27184844
- The Journal of biological chemistry 290:11199-2082015Opposing growth regulatory roles of protein kinase D isoforms in human keratinocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesVladislav Ryvkin et. al.PubMed 25802335
- Molecular cancer therapeutics 13:1130-412014Protein kinase d as a potential chemotherapeutic target for colorectal cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNing Wei et. al.PubMed 24634417
- Experimental cell research 319:2037-20482013Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEva Bernhart et. al.PubMed 23562655
- Proceedings of the National Academy of Sciences of the United States of America 110:2312-72013GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhong-Fa Yang,Haojian Zhang,Leyuan Ma,Cong Peng,Yaoyu Chen,Junling Wang,Michael R Green,Shaoguang Li,Alan G RosmarinPubMed 23345428
- American journal of physiology. Gastrointestinal a 303:G356-662012Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSteven H Young et. al.PubMed 22595992
- Frontiers in physiology 3:602012Protein kinase d regulates cell death pathways in experimental pancreatitis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingzhen Yuan et. al.PubMed 22470346
- Journal of cellular physiology 226:1074-812010Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNobuo Ochi,Suebpong Tanasanvimon,Yoichi Matsuo,Zhimin Tong,Bokyung Sung,Bharat B Aggarwal,James Sinnett-Smith,Enrique Rozengurt,Sushovan GuhaPubMed 20857418
- Molecular cancer therapeutics 9:1136-462010A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKuzhuvelil B Harikumar et. al.PubMed 20442301
Key facts
- CAS number
1883545-60-5
- Purity
> 99%
- Form
Solid
- Molecular weight
411.3 Da
- Molecular formula
C18H24Cl2N6O
- PubChem identifier
136664697
- Nature
Synthetic
Target data
Recommended products
MW 411.3 Da, Purity >99%. Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.
Also available in simple stock solutions (ab146740) - add 1 ml of water to get an exact, ready-to-use concentration.
Key facts
- CAS number
1883545-60-5
- Purity
> 99%
- Form
Solid
- Molecular weight
411.3 Da
- Molecular formula
C18H24Cl2N6O
- PubChem identifier
136664697
- Nature
Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
(R)-2-(4-((2-aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride
- Biological description
Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.
Also available in simple stock solutions (ab146740) - add 1 ml of water to get an exact, ready-to-use concentration.- Canonical SMILES
CCC(CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl
- Isomeric SMILES
CC[C@H](CNC1=NC(=NC=C1)C2=C(C=CC(=C2)C3=CN(N=C3)C)O)N.Cl.Cl
- InChI
InChI=1S/C18H22N6O.2ClH/c1-3-14(19)10-21-17-6-7-20-18(23-17)15-8-12(4-5-16(15)25)13-9-22-24(2)11-13;;/h4-9,11,14,25H,3,10,19H2,1-2H3,(H,20,21,23);2*1H/t14-;;/m1../s1
- InChIKey
CXYCRYGNFKDPRH-FMOMHUKBSA-N
- IUPAC name
2-[4-[[(2R)-2-aminobutyl]amino]pyrimidin-2-yl]-4-(1-methylpyrazol-4-yl)phenol;dihydrochloride
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Notes
Sold under license from CRT.
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1 product image
Chemical Structure - CRT0066101, protein kinase D inhibitor (ab144637)
2D chemical structure image of ab144637, CRT0066101, protein kinase D inhibitor
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