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AB146825

CRT5, protein kinase D inhibitor

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(1 Publication)

MW 454.6 Da, Purity >97%. Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
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Chemical Structure - CRT5, protein kinase D inhibitor (AB146825)
  • Chemical Structure

Lab

Chemical Structure - CRT5, protein kinase D inhibitor (AB146825)

2D chemical structure image of ab146825, CRT5, protein kinase D inhibitor

Key facts

CAS number

1034297-58-9

Purity

>97%

Form

Solid

form

Molecular weight

454.6 Da

Molecular formula

C<sub>2</sub><sub>8</sub>H<sub>3</sub><sub>0</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

58238286

Nature

Synthetic

Solubility

Soluble in DMSO to 50 mM

Biochemical name

Crt5 (crt0066051)

Biological description

Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.

Canonical smiles

CCOC1=CC2=C(C=C1)C=C(C=C2)C3=C(N=CC(=C3)C4=CC(=CC=C4)C(=O)NCCN(C)C)N

InChi

InChI=1S/C28H30N4O2/c1-4-34-25-11-10-20-14-22(9-8-21(20)16-25)26-17-24(18-31-27(26)29)19-6-5-7-23(15-19)28(33)30-12-13-32(2)3/h5-11,14-18H,4,12-13H2,1-3H3,(H2,29,31)(H,30,33)

InChiKey

XBDRAUPLGHAFCU-UHFFFAOYSA-N

IUPAC Name

3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide

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Complementary Products

Biochemicals

AB144637

CRT0066101, protein kinase D inhibitor

Chemical Structure - CRT0066101, protein kinase D inhibitor (AB144637)

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Biochemicals

AB146740

CRT0066101 (mM/ml), protein kinase D inhibitor

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB191866

VHH Single Domain Anti-Rabbit IgG Fc (HRP)

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - VHH Single Domain Anti-Rabbit IgG Fc (HRP) (AB191866)

  • 5
  • 2
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Biochemical journal 429:565-72 PubMed20497126

2010

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ian M Evans,Azadeh Bagherzadeh,Mark Charles,Tony Raynham,Chris Ireson,Alexandra Boakes,Lloyd Kelland,Ian C Zachary
View all publications
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