MW 454.6 Da, Purity >97%. Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
1034297-58-9
> 97%
Solid
454.6 Da
C28H30N4O2
58238286
Synthetic
MW 454.6 Da, Purity >97%. Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
1034297-58-9
> 97%
Solid
454.6 Da
C28H30N4O2
58238286
Synthetic
Soluble in DMSO to 50 mM.
Crt5 (crt0066051)
Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
CCOC1=CC2=C(C=C1)C=C(C=C2)C3=C(N=CC(=C3)C4=CC(=CC=C4)C(=O)NCCN(C)C)N
InChI=1S/C28H30N4O2/c1-4-34-25-11-10-20-14-22(9-8-21(20)16-25)26-17-24(18-31-27(26)29)19-6-5-7-23(15-19)28(33)30-12-13-32(2)3/h5-11,14-18H,4,12-13H2,1-3H3,(H2,29,31)(H,30,33)
XBDRAUPLGHAFCU-UHFFFAOYSA-N
3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide
Ambient - Can Ship with Ice
-20°C
Store under desiccating conditions
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2D chemical structure image of ab146825, CRT5, protein kinase D inhibitor
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com