MW 454.6 Da, Purity >97%. Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
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- Expert review of gastroenterology & hepatology 9:1143-62015Protein kinase D enzymes: novel kinase targets in pancreatic cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGeou-Yarh Liou,Peter StorzPubMed 26174103
- EMBO reports 12:785-962011Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYa Fu et. al.PubMed 21738220
- The Biochemical journal 429:565-722010Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIan M Evans,Azadeh Bagherzadeh,Mark Charles,Tony Raynham,Chris Ireson,Alexandra Boakes,Lloyd Kelland,Ian C ZacharyPubMed 20497126
Key facts
- CAS number
1034297-58-9
- Purity
> 97%
- Form
Solid
- Molecular weight
454.6 Da
- Molecular formula
C28H30N4O2
- PubChem identifier
58238286
- Nature
Synthetic
Recommended products
MW 454.6 Da, Purity >97%. Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
Key facts
- CAS number
1034297-58-9
- Purity
> 97%
- Form
Solid
- Molecular weight
454.6 Da
- Molecular formula
C28H30N4O2
- PubChem identifier
58238286
- Nature
Synthetic
- Solubility
Soluble in DMSO to 50 mM.
- Biochemical name
Crt5 (crt0066051)
- Biological description
Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.
- Canonical SMILES
CCOC1=CC2=C(C=C1)C=C(C=C2)C3=C(N=CC(=C3)C4=CC(=CC=C4)C(=O)NCCN(C)C)N
- InChI
InChI=1S/C28H30N4O2/c1-4-34-25-11-10-20-14-22(9-8-21(20)16-25)26-17-24(18-31-27(26)29)19-6-5-7-23(15-19)28(33)30-12-13-32(2)3/h5-11,14-18H,4,12-13H2,1-3H3,(H2,29,31)(H,30,33)
- InChIKey
XBDRAUPLGHAFCU-UHFFFAOYSA-N
- IUPAC name
3-[6-amino-5-(6-ethoxynaphthalen-2-yl)pyridin-3-yl]-N-[2-(dimethylamino)ethyl]benzamide
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions
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1 product image
Chemical Structure - CRT5, protein kinase D inhibitor (ab146825)
2D chemical structure image of ab146825, CRT5, protein kinase D inhibitor
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