MW 296.37 g/mol, Purity >97%. STAT3 inhibitor (IC50 = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti-inflammatory, antidiabetes and antiobesity activity. Attenuates amyloid plaque deposition in the brain.
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- Frontiers in pharmacology 10:13382019Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChongyang Wang et. al.PubMed 31780948
Key facts
- CAS number
- 35825-57-1
- Purity
- > 97%
- Form
- Solid
- Source
- Salvia miltiorrhiza
- Molecular weight
- 296.37 g/mol
- Molecular formula
- C19H20O3
- Nature
- Native
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MW 296.37 g/mol, Purity >97%. STAT3 inhibitor (IC50 = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti-inflammatory, antidiabetes and antiobesity activity. Attenuates amyloid plaque deposition in the brain.
Key facts
- CAS number
- 35825-57-1
- Purity
- > 97%
- Form
- Solid
- Source
- Salvia miltiorrhiza
- Molecular weight
- 296.37 g/mol
- Molecular formula
- C19H20O3
- Nature
- Native
- Solubility
Soluble in DMSO to 10 mM.
- Biological description
STAT3 inhibitor (IC50 = 4.6 μM). Cell-permeable, naturally occuring constitutent of Salvia miltiorrhiza with diverse biological activities. Shows anticancer, antibacterial, anti-inflammatory, antidiabetes and antiobesity activity. Attenuates amyloid plaque deposition in the brain.
- IUPAC name
- (R)-(-)-1,6,6-Trimethyl-1,2,6,7,8,9-hexahydrophenanthro[1,2-b]furan-10,11-dione
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
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2 product images
Chemical Structure - Cryptotanshinone, STAT3 inhibitor (ab120666)
2D chemical structure image of ab120666, Cryptotanshinone, STAT3 inhibitor
Functional Studies - Cryptotanshinone, STAT3 inhibitor (ab120666)
MCF7 cells were incubated at 37°C for 4h with vehicle control (0 μM) and different concentrations of cryptotanshinone (ab120666). Increased expression of JNK1+JNK2 (phospho T183 + Y185) in MCF7cells correlates with an increase in cryptotanshinone concentration, as described in literature.
Whole cell lysates were prepared with RIPA buffer (containing protease inhibitors and sodium orthovanadate), 10 μg of each were loaded on the gel and the WB was run under reducing conditions. After transfer the membrane was blocked for an hour using 5% BSA before being incubated with Anti-JNK1 + JNK2 (phospho T183 + Y185) antibody ab4821 at at 1/1000 dilution and Anti-beta Actin antibody ab8227 at 1 μg/ml overnight at 4°C. Antibody binding was detected using an anti-rabbit antibody conjugated to HRP (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/10000 dilution and visualised using ECL development solution.
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