JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB143095

Crystal violet, Cation-based violet dye

Be the first to review this product! Submit a review

|

(2 Publications)

MW 408 Da. Cation-based violet dye. Interacts with aqueous KI - I2 during Gram staining to produce a precipitate. Histological stain for Gram-positive bacteria and DNA. Shows antibacterial, antifungal, and anthelmintic effects in vivo. .

View Alternative Names

3dopamine receptor, 5 HT2 receptor, 5-HT-2, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 2A, 5HT2A_HUMAN, A2AAR, A2aR, AA2AR_HUMAN, ACLS, ACM3_HUMAN, ACM4_HUMAN, ACM5_HUMAN, AChR, AChR M5, ADA1D_HUMAN, ADA2A_HUMAN, ADA2C_HUMAN, ADENO, ADORA 2, ADORA2A, ADRA1A, ADRA1L1, ADRA2, ADRA2A, ADRA2L2, ADRA2R, ADRA2RL1, ADRA2RL2, ADRAR, ADRARL1, ADRARL2, AI413597, AI838772, AIS, ANDR_HUMAN, AR, AR8, ARO, ARO1, AW045860, AW493413, Acetylcholine receptor muscarinic 5, Adenosine A2 receptor, Adenosine A2a receptor, Adenosine receptor A2a, Adenosine receptor subtype A2a, Adra 2c, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Adrenergic alpha 2A receptor, Adrenergic alpha 2C receptor, Adrenoceptor alpha 2C, Alpha 2 adrenergic receptor subtype C2, Alpha 2AAR subtype C10, Alpha 2B adrenoceptor, Alpha 2B adrenoreceptor, Alpha 2C adrenergic receptor subtype C4, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C4, Alpha-2-adrenergic receptor, renal type, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-2C adrenergic receptor, Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, Alpha-synuclein, Alpha-synuclein, isoform NACP140, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Aromatase, Atherosclerosis, susceptibility to, included, CHKM5MR, CHRM 3, CHRM1, CP19A_HUMAN, CPV1, CYAR, CYP19, CYPXIX, Cholinergic receptor muscarinic 1, Cholinergic receptor muscarinic 4, Cholinergic receptor muscarinic 5, Chrm 4, Chrm 5, Cyp19a1, Cytochrome P-450AROM, Cytochrome P450 19A1, Cytochrome P450, family 19, subfamily A, polypeptide 1, Cytochrome P450, subfamily XIX (aromatization of androgens), D(1A) dopamine receptor, D(2) dopamine receptor, D(3) dopamine receptor, D1A dopamine receptor, D2 dopamine receptor, D2DR, D2R, DADR, DDPAC, DHTR, DKFZp686N23123, DNA binding protein, DRD 1A, DRD1_HUMAN, DRD2_HUMAN, DRD3_HUMAN, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), Dopamine D1 receptor, Dopamine D2 receptor, Dopamine D3 receptor, Dopamine receptor D2, Dopamine receptor D3, EGBRS, ER, ER-alpha, ER-beta, ERK-2, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ERT1, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, ETM1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen synthase, Estrogen synthetase, Estrogen-related receptor alpha, Estrra, Extracellular signal-regulated kinase 2, FET1, FLJ11090, FLJ31424, FTDP 17, G protein beta1/gamma2 subunit interacting factor 1, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Gastric receptor 1, Gastric receptor I, Glioma associated oncogene family zinc finger 3, HDL cholesterol, augmented response of, to hormone replacement, included, HGNC:5183, HH2R, HM 3, HM 4, HM 5, HM1, HRH2_HUMAN, HTR 2, HTR 2A, HTR2, formerly, HUMARA, HYSP1, Histamine H2 receptor, Histamine receptor H2, IMD42, K-OR-1, KD, Kappa opioid receptor, Kappa-type opioid receptor, Kennedy disease (KD), LMOR, M-OR-1, M3 muscarinic receptor, M4, M5R, MAP kinase 1, MAP kinase 2, MAP kinase isoform p42, MAPK 1, MAPT, MAPTL, MGC104252, MGC104309, MGC105443, MGC110988, MGC112732, MGC127560, MGC129539, MGC134287, MGC138549, MGC156663, MGC41838, MGC64356, MK01_HUMAN, MOR, MSTD, MTBT1, MTBT2, Microsomal monooxygenase, Microtubule associated protein tau isoform 4, Microtubule-associated protein tau, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 2, Mtapt, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M4, Muscarinic acetylcholine receptor M5, Myocardial infarction, susceptibility to, included, NACP, NK-2 receptor, NK2R_HUMAN, NKNAR, NR1F3, NR3A1, NR3A2, NR3B1, NR3C4, Neurofibrillary tangle protein, Neurokinin 2 receptor, Neurokinin A receptor, Non A4 component of amyloid, Non-A beta component of AD amyloid, Non-A-beta component of alzheimers disease amyloid , precursor of, Non-A4 component of amyloid precursor, Non-A4 component of amyloid, precursor of, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), OPRK 1, OPRK_HUMAN, OPRM1, OPRM_HUMAN, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000058849, OTTHUMP00000161242, OTTHUMP00000161243, OTTHUMP00000162543, OTTHUMP00000198350, OTTHUMP00000218549, OTTHUMP00000218551, OTTHUMP00000218552, OTTHUMP00000218553, OTTHUMP00000218554, Oncogene GLI3, Opiate receptor kappa 1, Opioid receptor mu 1, Opioid receptor, kappa 1, Oprk2, P 450AROM, P38, P41, PAP A, PAPB, PARK 1, PARK 4, PHF-tau, PPD IV, PPND, PPP1R103, PRKM 2, PRKM1, Paired helical filament-tau, Parkinson disease (autosomal dominant, Lewy body) 4, Parkinson disease familial 1, Protein phosphatase 1, regulatory subunit 103, R21, RAR related orphan nuclear receptor variant 2, RAR related orphan receptor C, isoform a, RAR related orphan receptor gamma, RAR-related orphan receptor C, RDC 8, RNESTROR, RNPTAU, RORG_HUMAN, RP24-311F12.2, RZR GAMMA, RZRG, Retinoic acid binding receptor gamma, Retinoid-related orphan receptor-gamma, Rorc, SBMA, SCAN1, SKR, SMAX1, SNCA, SYN, SYUA_HUMAN, Serotonin receptor 2A, Seven transmembrane helix receptor, Snca synuclein, Snca synuclein, alpha (non A4 component of amyloid precursor), Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, Substance-K receptor, Subtype alpha2 C4, Synuclein alpha, Synuclein alpha 140, Synuclein, alpha (non A4 component of amyloid precursor), TAC 2R, TAC R2, TACR 2, TACR2, TAU_HUMAN, TFM, TOR, TYDP, TYDP1_HUMAN, Tachykinin receptor 2, Tachykinin receptor 2 (substance K receptor; neurokinin 2 receptor), Tauopathy and respiratory failure, Tauopathy and respiratory failure, included, Testicular Feminization (TFM), Transcriptional activator GLI3, Transcriptional repressor GLI3R, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, Zinc finger protein GLI 3, alpha 2BAR, alpha-2-adrenergic receptor, platelet type, alpha2 AR C4, alpha2 C4, alpha2C, alpha2cii-adrenergic receptor, alphaSYN, androgen receptor splice variant 4b, cholinergic receptor muscarinic 3, dopamine receptor D1, estrogen receptor related receptor alpha, flavoprotein-linked monooxygenase, hA2aR, hERR1, hMOP, m3 muscarinic acetylcholine receptor, m5, muscarinic 3, muscarinic cholinergic m3 receptor, muscarinic m3 receptor, p42-MAPK, pTau, protein kinase, mitogen-activated, 1, protein kinase, mitogen-activated, 2, protein tyrosine kinase ERK2, serotonin 5-HT-2 receptor, formerly, serotonin 5-HT-2A receptor

1 Images
Chemical Structure - Crystal violet, Cation-based violet dye (AB143095)
  • Chemical Structure

Lab

Chemical Structure - Crystal violet, Cation-based violet dye (AB143095)

2D chemical structure image of ab143095, Crystal violet, Cation-based violet dye

Key facts

CAS number

548-62-9

Form

Powder

form

Molecular weight

408 Da

Molecular formula

C<sub>2</sub><sub>5</sub>H<sub>3</sub><sub>0</sub>N<sub>3</sub>.Cl

PubChem

11057

Nature

Synthetic

Solubility

Soluble in water to 25 mM,

Soluble in DMSO to 100 mM

Soluble in ethanol to 10 mM

Biochemical name

Gentian Violet

Biological description

Cation-based violet dye. Interacts with aqueous KI - I2 during Gram staining to produce a precipitate. Histological stain for Gram-positive bacteria and DNA. Shows antibacterial, antifungal, and anthelmintic effects in vivo.

Canonical smiles

CN(C)C1=CC=C(C=C1)C(=C2C=CC(=[N+](C)C)C=C2)C3=CC=C(C=C3)N(C)C.[Cl-]

InChi

InChI=1S/C25H30N3.ClH/c1-26(2)22-13-7-19(8-14-22)25(20-9-15-23(16-10-20)27(3)4)21-11-17-24(18-12-21)28(5)6;/h7-18H,1-6H3;1H/q+1;/p-1

InChiKey

ZXJXZNDDNMQXFV-UHFFFAOYSA-M

IUPAC Name

[4-[bis[4-(dimethylamino)phenyl]methylidene]cyclohexa-2,5-dien-1-ylidene]-dimethylazanium;chloride

Product details

REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tau also known as MAPT is a protein with significant roles in the nervous system. Its molecular weight ranges from 48 to 67 kDa varying due to alternative splicing. Tau is expressed mainly in neurons but also found in astrocytes and oligodendrocytes. Mechanically it stabilizes microtubules by binding to them which is essential for maintaining neural cell shape and facilitating intracellular transport. MAPK1 also known as ERK2 is a serine/threonine kinase involved in cellular functions such as proliferation and differentiation. It has a molecular weight of approximately 41 kDa and is expressed in almost all tissues.
Biological function summary

MAPT contributes to neural stability by maintaining the integrity of axonal microtubules. It is an important component of the cytoskeletal network and affects neuronal viability. MAPK1 part of the MAPK family plays important roles in relaying extracellular signals to intracellular responses. It forms part of signaling complexes that transmit growth factor signals to the nucleus affecting gene expression. Estrogen receptors found in diverse tissues like breast and brain mediate cellular responses to estrogen impacting reproductive and non-reproductive systems.

Pathways

MAPT interacts within the axon guidance pathway influencing neural development and synaptic plasticity. It's also involved in neurotrophic factor-mediated signaling. MAPK1 functions prominently within the MAPK/ERK pathway which modulates cell cycle progression and differentiation. Both proteins interact with several kinases and phosphatases including those from the ERK pathway that are important for signal transduction. Estrogen receptors engage in the PI3K/AKT and Ras/MAPK pathways regulating cell growth and survival.

Abnormal MAPT accumulation leads to tauopathies like Alzheimer's disease impacting synaptic function. It also interacts with other proteins like alpha-synuclein contributing to neurodegenerative processes. MAPK1 has been linked to various cancers due to its role in regulating cell division and proliferation. It associates with ERBB receptors in this context. Estrogen receptors relate to breast cancer where their activation influences tumor growth. Drugs targeting estrogen receptors like aromatase inhibitors are used in breast cancer treatment.

Product protocols

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 14:979-995 PubMed38590406

2024

Novel chromium (III)-based compound for inhibition of oxaliplatin-resistant colorectal cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Cheng Chen,Hema Sri Devi,Hsueh-Fa Pien,Shina Fong-Mei Wen,Jenn-Line Sheu,Bruce Chi-Kang Tsai,Chih-Yang Huang,Yu-Jung Lin

Orthopaedic surgery 12:964-973 PubMed32363797

2020

Role of Junction-Mediating and Regulatory Protein in the Pathogenesis of Glucocorticoid-Induced Endothelial Cell Lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zuo,Wan-Shou Guo,Hua-Chen Yu,Pei Liu,Qi-Dong Zhang
View all publications

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com