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AB120618

Curcumin (Diferuloylmethane), Lipooxygenase inhibitor

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(1 Publication)

MW 368.4 Da. High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo.
2 Images
Immunocytochemistry/ Immunofluorescence - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (AB120618)
  • ICC/IF

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Immunocytochemistry/ Immunofluorescence - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (AB120618)

ab32137 staining c-Jun in HeLa cells treated with curcumin (diferuloylmethane) (ab120618), by ICC/IF. Decrease in c-Jun expression correlates with increased concentration of curcumin (diferuloylmethane) as described in literature.
The cells were incubated at 37°C for 4h in media containing different concentrations of ab120618 (curcumin (diferuloylmethane)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32137 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (AB120618)
  • Chemical Structure

Lab

Chemical Structure - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (AB120618)

2D chemical structure image of ab120618, Curcumin (Diferuloylmethane), Lipooxygenase inhibitor

Key facts

CAS number

458-37-7

Form

Solid

form

Molecular weight

368.4 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>0</sub>O<sub>6</sub>

PubChem

969516

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 10 mM

Biochemical name

Curcumin

Biological description

High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo

Canonical smiles

COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Isomeric smiles

COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

InChi

InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChiKey

VFLDPWHFBUODDF-FCXRPNKRSA-N

IUPAC Name

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 11:e0163260 PubMed27644036

2016

Demethoxycurcumin Is A Potent Inhibitor of P-Type ATPases from Diverse Kingdoms of Life.

Applications

Unspecified application

Species

Unspecified reactive species

Trong Tuan Dao,Pankaj Sehgal,Truong Thanh Tung,Jesper Vuust Møller,John Nielsen,Michael Palmgren,Søren Brøgger Christensen,Anja Thoe Fuglsang
View all publications
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