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MW 368.4 Da. High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo.

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Images

Chemical Structure - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (AB120618), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (AB120618), expandable thumbnail

Publications

Key facts

CAS number

458-37-7

Form

Solid

Molecular weight

368.4 Da

Molecular formula

C21H20O6

PubChem identifier

969516

Nature

Synthetic

Alternative names

Recommended products

MW 368.4 Da. High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo.

Key facts

PubChem identifier

969516

Solubility

Soluble in ethanol to 10 mM. Soluble in DMSO to 10 mM.

Biochemical name

Curcumin

Biological description

High purity flavonoid derivative. Potent antioxidant, anti-inflammatory, analgesic and anticancer agent. Lipooxygenase and cyclooxygenase inhibitor (IC50 values are 8 and 52 μM, respectively). Shows diverse range of actions including free radical scavenging activity, cardio and neuroprotective effects. Blood brain barrier permeable. Active in vitro and in vivo

Canonical SMILES

COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Isomeric SMILES

COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

InChI

InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChIKey

VFLDPWHFBUODDF-FCXRPNKRSA-N

IUPAC name

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

-20°C

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

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2 product images

  • Chemical Structure - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (ab120618), expandable thumbnail

    Chemical Structure - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (ab120618)

    2D chemical structure image of ab120618, Curcumin (Diferuloylmethane), Lipooxygenase inhibitor

  • Immunocytochemistry/ Immunofluorescence - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (ab120618), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Curcumin (Diferuloylmethane), Lipooxygenase inhibitor (ab120618)

    Anti-c-Jun antibody [E254] - ChIP Grade ab32137 staining c-Jun in HeLa cells treated with curcumin (diferuloylmethane) (ab120618), by ICC/IF. Decrease in c-Jun expression correlates with increased concentration of curcumin (diferuloylmethane) as described in literature.
    The cells were incubated at 37°C for 4h in media containing different concentrations of ab120618 (curcumin (diferuloylmethane)) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-c-Jun antibody [E254] - ChIP Grade ab32137 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

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