JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB144327

Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog

Be the first to review this product! Submit a review

|

(0 Publication)

MW 349.3 Da, Purity >98%. Stable, cell-permeable analog of pifithrin-α (ab120478). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Potent STAT6 transcriptional inhibitor. Active in vivo and in vitro.

See similar compound.
1 Images
Chemical Structure - Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog (AB144327)
  • Chemical Structure

Lab

Chemical Structure - Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog (AB144327)

2D chemical structure image of ab144327, Cyclic Pifithrin-alpha hydrobromide, pifithrin-alpha analog

Key facts

CAS number

511296-88-1

Purity

>98%

Form

Solid

form

Molecular weight

349.3 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>1</sub><sub>7</sub>BrN<sub>2</sub>S

PubChem

11515812

Nature

Synthetic

Solubility

Soluble in ethanol to 25 mM

Soluble in DMSO to 100 mM

Biochemical name

Pifithrin-beta hydrobromide

Biological description

Stable, cell-permeable analog of pifithrin-α (ab120478). Inhibits p53-mediated apoptosis and p53-dependent gene transcription. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Potent STAT6 transcriptional inhibitor. Active in vivo and in vitro.

See similar compound

Canonical smiles

CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2.Br

InChi

InChI=1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H

InChiKey

SGNCOAOESGSEOP-UHFFFAOYSA-N

IUPAC Name

2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column
style
left-column
style
right-column

Complementary Products

Biochemicals

AB120065

SP600125, JNK inhibitor

Chemical Structure - SP600125, JNK inhibitor (AB120065)

  • 0
  • 0
Primary Antibodies

AB124956

Anti-JNK1 + JNK2 + JNK3 (phospho T183+T183+T221) antibody [EPR5693]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-JNK1 + JNK2 + JNK3 (phospho T183+T183+T221) antibody [EPR5693] (AB124956)

  • 4
  • 7
Primary Antibodies

AB179461

Anti-JNK1 + JNK2 + JNK3 antibody [EPR16797-211]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-JNK1 + JNK2 + JNK3 antibody [EPR16797-211] (AB179461)

  • 4
  • 7
Primary Antibodies

AB32385

Anti-c-Jun (phospho S63) antibody [Y172]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-c-Jun (phospho S63) antibody [Y172] (AB32385)

  • 5
  • 4

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com