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AB146030

Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor

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MW 299.3 Da, Purity >99%. Cell-permeable transcriptional p53 inhibitor. Shows potent neuroprotective effects (ED50 = 30 nM, etoposide-induced cortical neuron death). Shows a 50% longer half-life than Pifithrin-α (ab120478).
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Chemical Structure - Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor (AB146030)
  • Chemical Structure

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Chemical Structure - Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor (AB146030)

2D chemical structure image of ab146030, Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor

Key facts

CAS number

60477-38-5

Purity

>99%

Form

Solid

form

Molecular weight

299.3 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>3</sub>N<sub>3</sub>O<sub>2</sub>S

PubChem

4587369

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

2-(4-Nitrophenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole

Biological description

Cell-permeable transcriptional p53 inhibitor. Shows potent neuroprotective effects (ED50 = 30 nM, etoposide-induced cortical neuron death). Shows a 50% longer half-life than Pifithrin-α (ab120478).

Canonical smiles

C1CCC2=C(C1)N3C=C(N=C3S2)C4=CC=C(C=C4)[N+](=O)[O-]

InChi

InChI=1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2

InChiKey

XMFNSEDROOHGBY-UHFFFAOYSA-N

IUPAC Name

2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Complementary Products

Assay Kits

AB207225

p53 Transcription Factor Assay Kit (Colorimetric)

Functional Studies - p53 Transcription Factor Assay Kit (Colorimetric) (AB207225)

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Sample Prep & Detection Kits

AB154470

p53 Human Immunocapture Kit

Immunoprecipitation - p53 Human Immunocapture Kit (AB154470)

  • 0
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Primary Antibodies

AB26

Anti-p53 antibody [PAb 240]

KO Validated|Lab Essentials

Western blot - Anti-p53 antibody [PAb 240] (AB26)

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  • 56
Assay Kits

AB189819

Membrane fluidity kit

Fluorescent Cell Imaging - Membrane fluidity kit (AB189819)

  • 0
  • 0

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