AB120093

Cycloheximide, Protein synthesis inhibitor

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(34 Publications)

MW 281.35 Da, Purity >98%. Protein synthesis inhibitor. Antifungal antibiotic. Achieve your results faster with highly validated, pure and trusted compounds.

2 Images

Functional Studies - Cycloheximide, Protein synthesis inhibitor (AB120093)

FuncS

Unknown

Functional Studies - Cycloheximide, Protein synthesis inhibitor (AB120093)

Functional assays : Caspase 8 (active) FITC Staining Kit (ab65614)

Active caspase 8 in control Jurkat cells (10e6/mL) or cells treated for five hours with 10 ug/mL Cyclohexamide (CHX) (ab120093) or four hours with 25 ug/mL Mitomycin C (MitoC) (ab120797). Background signal subtracted, duplicates; +/- SD.

Chemical Structure - Cycloheximide, Protein synthesis inhibitor (AB120093)

Chemical Structure

Lab

Chemical Structure - Cycloheximide, Protein synthesis inhibitor (AB120093)

2D chemical structure image of ab120093, Cycloheximide, Protein synthesis inhibitor

Key facts

CAS number

66-81-9

Purity

>98%

Form

Solid

form

Molecular weight

281.35 Da

Molecular formula

C15H23NO4

PubChem

6197

Nature

Synthetic

Solubility

Soluble in water to 25 mM

Biochemical name

Cycloheximide

Biological description

Protein synthesis inhibitor. Antifungal antibiotic.

Canonical smiles

CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C

Isomeric smiles

C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C

InChi

InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1

InChiKey

YPHMISFOHDHNIV-FSZOTQKASA-N

IUPAC Name

4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

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Properties and storage information

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions|The product can be stored for up to 12 months

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Product protocols

Visit the General protocols
Visit the Troubleshooting

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Publications (34)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 16:260 PubMed40025303

2025

Mechanistic insights into Uc001kfo-induced hepatocellular carcinoma metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Yanfeng Pan,Qin Liu,Qingqing Li,Zhenjun Ren

Molecular medicine (Cambridge, Mass.) 30:82 PubMed38862918

2024

ERRFI1 exacerbates hepatic ischemia reperfusion injury by promoting hepatocyte apoptosis and ferroptosis in a GRB2-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Hang Zhao,Huizi Mao

Journal of cellular and molecular medicine 28:e18216 PubMed38652219

2024

MELK aggravates lung adenocarcinoma by regulating EZH2 ubiquitination and H3K27me3 histone methylation of LATS2.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Yu,Xianrong Xu,Lirong Zhu,Shengjie Chen,Jincheng He

Cell death discovery 10:165 PubMed38575580

2024

Tryptophanyl-tRNA synthetase-1 (WARS-1) depletion and high tryptophan concentration lead to genomic instability in Caenorhabditis elegans.

Applications

Unspecified application

Species

Unspecified reactive species

Mahmoud Izadi,Tayyiba Akbar Ali,Farah M Shurrab,Ebrahim Aharpour,Ehsan Pourkarimi

iScience 27:109136 PubMed38510136

2024

Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Cardanho-Ramos,Rúben Alves Simões,Yi-Zhi Wang,Andreia Faria-Pereira,Ewa Bomba-Warczak,Katleen Craessaerts,Marco Spinazzi,Jeffrey N Savas,Vanessa A Morais

iScience 27:108822 PubMed38303721

2024

Nudt21-mediated alternative polyadenylation of MZT1 3'UTR contributes to pancreatic cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhou,Jiabin Yang,Leyi Huang,Chao Liu,Min Yu,Rufu Chen,Quanbo Zhou

Nature biotechnology : PubMed38238480

2024

KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions.

Applications

Unspecified application

Species

Unspecified reactive species

Tong Wu,Anthony Youzhi Cheng,Yuexiu Zhang,Jiayu Xu,Jinjun Wu,Li Wen,Xiao Li,Bei Liu,Xiaoyang Dou,Pingluan Wang,Linda Zhang,Jingyi Fei,Jianrong Li,Zhengqing Ouyang,Chuan He

Cell reports 42:113418 PubMed37963018

2023

Single-cell analysis reveals a weak macrophage subpopulation response to Mycobacterium tuberculosis infection.

Applications

Unspecified application

Species

Unspecified reactive species

Sydney L Solomon,Bryan D Bryson

International journal of molecular sciences 24: PubMed37762644

2023

Nuclear NPM-ALK Protects Myc from Proteasomal Degradation and Contributes to Its High Expression in Cancer Stem-Like Cells in ALK-Positive Anaplastic Large Cell Lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Chuquan Shang,Justine Lai,Moinul Haque,Will Chen,Peng Wang,Raymond Lai

The Journal of neuroscience : the official journal of the Society for Neuroscience 43:2440-2459 PubMed36849416

2023

Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.

Applications

Unspecified application

Species

Unspecified reactive species

Mina N Anadolu,Jingyu Sun,Senthilkumar Kailasam,Kleanthi Chalkiadaki,Konstanze Krimbacher,Jewel T-Y Li,Teodora Markova,Seyed M Jafarnejad,Francois Lefebvre,Joaquin Ortega,Christos G Gkogkas,Wayne S Sossin

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Product promise

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Cycloheximide, Protein synthesis inhibitor

Functional Studies - Cycloheximide, Protein synthesis inhibitor (AB120093)

Chemical Structure - Cycloheximide, Protein synthesis inhibitor (AB120093)

Key facts

CAS number

Purity

Form

Molecular weight

Molecular formula

PubChem

Nature

Solubility

Biochemical name

Biological description

Canonical smiles

Isomeric smiles

InChi

InChiKey

IUPAC Name

Properties and storage information

Shipped at conditions

Appropriate long-term storage conditions

Storage information

Product protocols

Publications (34)

Complementary Products

Primary Antibodies

Secondary Antibodies

Biochemicals

Primary Antibodies

Product promise