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AB141240

Cyclophosphamide, Alkylating agent

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MW 261.08 Da, Purity >99%. Alkylating agent; pro-drug capable of inducing DNA single-strand breaks. Efficacious in vitro and in vivo. Chemotherapeutic effects due to inhibition of Bax and Bcl-2 expression when administered with etoposide (ab120227).
1 Images
Chemical Structure - Cyclophosphamide, Alkylating agent (AB141240)
  • Chemical Structure

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Chemical Structure - Cyclophosphamide, Alkylating agent (AB141240)

2D chemical structure image of ab141240, Cyclophosphamide, Alkylating agent

Key facts

CAS number

50-18-0

Purity

>99%

Form

Solid

form

Molecular weight

261.08 Da

Molecular formula

C<sub>7</sub>H<sub>1</sub><sub>5</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub>P

PubChem

2907

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in DMSO to 100 mM

Biochemical name

Cyclophosphamide

Biological description

Alkylating agent; pro-drug capable of inducing DNA single-strand breaks. Efficacious in vitro and in vivo. Chemotherapeutic effects due to inhibition of Bax and Bcl-2 expression when administered with etoposide (ab120227).

Canonical smiles

C1CNP(=O)(OC1)N(CCCl)CCCl

InChi

InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)

InChiKey

CMSMOCZEIVJLDB-UHFFFAOYSA-N

IUPAC Name

N,N-bis(2-chloroethyl)-2-oxo-1,3,2λ5-oxazaphosphinan-2-amine

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Complementary Products

Biochemicals

AB141248

Docetaxel, Cytotoxic agent

Chemical Structure - Docetaxel, Cytotoxic agent (AB141248)

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  • 0
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56
Biochemicals

AB120629

Doxorubicin hydrochloride, Topoisomerase II inhibitor

Chemical Structure - Doxorubicin hydrochloride, Topoisomerase II inhibitor (AB120629)

  • 0
  • 0
Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

CBX1 also known as HP1 beta is a chromatin-associated protein that plays an important role in chromatin organization and epigenetic regulation. This protein has a mass of approximately 22 kDa and localizes within the nucleus where it participates in heterochromatin formation. CBX1 recognizes and binds to histone H3 when it is methylated at lysine 9 (H3K9me3) a modification integral to forming tightly packed DNA regions. Expression of CBX1 occurs widely in many tissue types reflecting its fundamental role in genomic maintenance and cell cycle regulation.
Biological function summary

The CBX1 protein acts as an integral component of the chromatin remodeling complex. By binding to methylated histones CBX1 helps stabilize chromatin architecture and repress transcription of genes within heterochromatic regions. This function is essential for maintaining gene silencing which is critical for processes like development and differentiation. CBX1 collaborates with other HP1 isoforms such as HP1 alpha and HP1 gamma as part of the family of heterochromatin proteins that contribute collectively to chromatin dynamics and gene expression control.

Pathways

CBX1 plays a part in the epigenetic transcriptional repression and cell cycle regulation pathways. It associates with SUV39H1 a methyltransferase to recognize and bind the H3K9me3 mark adding stability to the methylation signal and contributing to gene silencing. Additionally CBX1 interacts with other proteins like DNMT1 a DNA methyltransferase reinforcing its role in sustaining repressive chromatin states and preserving genome integrity during DNA replication.

CBX1 holds a significant association with cancer and neurological disorders. Aberrant expression or mutations in CBX1 can lead to disrupted chromatin states influencing oncogene activation or tumor suppressor gene silencing which are common events in cancer development. Furthermore altered CBX1 function links to neurological disorders where inappropriate chromatin remodeling contributes to disease pathology. Changes in the expression and interaction with other proteins including HP1 alpha highlight its potential role in disease mechanisms making CBX1 a relevant target for therapeutic research.
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Product protocols

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