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AB120300

Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor

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(9 Publications)

MW 336.4 Da, Purity >99%. Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase. Achieve your results faster with highly validated, pure and trusted compounds.
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Chemical Structure - Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor (AB120300)
  • Chemical Structure

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Chemical Structure - Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor (AB120300)

2D chemical structure image of ab120300, Cyclopiazonic acid from Penicillium grisefulvum, Ca2+-ATPase inhibitor

Key facts

CAS number

18172-33-3

Purity

>99%

Form

Solid

form

Source

Penicillium grisefulvum

Molecular weight

336.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

54682463

Nature

Native

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 5 mM

Biochemical name

9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aR,11aS,11bR)-

Biological description

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase.

Canonical smiles

CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O

Isomeric smiles

CC(=O)C1=C([C@@H]2[C@@H]3[C@@H](CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O

InChi

InChI=1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,24H,7H2,1-3H3/t12-,16+,17+/m1/s1

InChiKey

SZINUGQCTHLQAZ-DQYPLSBCSA-N

IUPAC Name

(2R,3S,9R)-5-acetyl-4-hydroxy-8,8-dimethyl-7,16-diazapentacyclo[9.6.1.02,9.03,7.015,18]octadeca-1(17),4,11(18),12,14-pentaen-6-one

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 7:220 PubMed38388802

2024

Synchronous force and Ca measurements for repeated characterization of excitation-contraction coupling in human myocardium.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengwu Sun,Kun Lu,Christine Kamla,Petra Kameritsch,Thomas Seidel,Andreas Dendorfer

npj aging 9:5 PubMed37002232

2023

Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum.

Applications

Unspecified application

Species

Unspecified reactive species

Sara M Zarate,Taylor E Huntington,Pooneh Bagher,Rahul Srinivasan

Cells 10: PubMed33494218

2021

Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Alice Rossi,Luisa Galla,Chiara Gomiero,Lorena Zentilin,Mauro Giacca,Valentina Giorgio,Tito Calì,Tullio Pozzan,Elisa Greotti,Paola Pizzo

Biomaterials 259:120283 PubMed32827796

2020

Bile canaliculi contract autonomously by releasing calcium into hepatocytes via mechanosensitive calcium channel.

Applications

Unspecified application

Species

Unspecified reactive species

Kapish Gupta,Inn Chuan Ng,Gowri Manohari Balachander,Binh P Nguyen,Lisa Tucker-Kellogg,Boon Chuan Low,Hanry Yu

Cell reports 30:2332-2348.e10 PubMed32075767

2020

Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models.

Applications

Unspecified application

Species

Unspecified reactive species

Alice Rossi,Giulia Rigotto,Giulia Valente,Valentina Giorgio,Emy Basso,Riccardo Filadi,Paola Pizzo

Autophagy 15:2044-2062 PubMed30892128

2019

PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara Fedeli,Riccardo Filadi,Alice Rossi,Cristina Mammucari,Paola Pizzo

Journal of neurophysiology 111:1369-82 PubMed24381027

2014

Age- and location-dependent differences in store depletion-induced h-channel plasticity in hippocampal pyramidal neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Ann M Clemens,Daniel Johnston

Proceedings of the National Academy of Sciences of 109:2601-6 PubMed22308379

2012

Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jordan D T Engbers,Dustin Anderson,Hadhimulya Asmara,Renata Rehak,W Hamish Mehaffey,Shahid Hameed,Bruce E McKay,Mirna Kruskic,Gerald W Zamponi,Ray W Turner

Brain, behavior, and immunity 25:1399-407 PubMed21521651

2011

Neuronal Fc-gamma receptor I mediated excitatory effects of IgG immune complex on rat dorsal root ganglion neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Lintao Qu,Pu Zhang,Robert H LaMotte,Chao Ma
View all publications
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