MW 1202.6 Da, Purity >99%. Immunosuppressant. Complexes with cyclophilin to inhibit the phosphatase activity of calcineurin (PP2B). Please see CofA for batch specific MW.
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14 Publications for All applications
- Cells 11:2022The Degradation of TMEM166 by Autophagy Promotes AMPK Activation to Protect SH-SY5Y Cells Exposed to MPP.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhaozhong Liao,Zunshuang Gong,Zhe Wang,Weiyan Yang,Wenjing Liu,Lin Hou,Xiaokun Liu,Junnan Hua,Bin Wang,Ning LiPubMed 36078115
- Fluids and barriers of the CNS 18:102021Protecting P-glycoprotein at the blood-brain barrier from degradation in an Alzheimer's disease mouse model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYujie Ding,Yu Zhong,Andrea Baldeshwiler,Erin L Abner,Björn Bauer,Anika M S HartzPubMed 33676539
- Arteriosclerosis, thrombosis, and vascular biology 41:e160-e1742021Inhibition of T-Cells by Cyclosporine A Reduces Macrophage Accumulation to Regulate Venous Adaptive Remodeling and Increase Arteriovenous Fistula Maturation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYutaka Matsubara (松原裕),Gathe Kiwan,Jia Liu (刘佳),Luis Gonzalez,John Langford,Mingjie Gao (高明杰),Xixiang Gao (高喜翔),Ryosuke Taniguchi (谷口良輔),Bogdan Yatsula,Tadashi Furuyama (古山正),Takuya Matsumoto (松本拓也),Kimihiro Komori (古森公浩),Alan DardikPubMed 33472405
- American journal of cancer research 10:2895-29082020CD38 triggers inflammasome-mediated pyroptotic cell death in head and neck squamous cell carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMin-Juan Zhang et. al.PubMed 33042624
- Journal of immunology (Baltimore, Md. : 1950) 203:2630-26432019Controls Germinal Center Reaction by Relaying a Wnt Signal to the Expression in Centroblasts during Humoral Immune Responses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSeung Young Choi et. al.PubMed 31586036
- Transplantation 103:1603-16112019Ultrasound Molecular Imaging of Lymphocyte-endothelium Adhesion Cascade in Acute Cellular Rejection of Cardiac Allografts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYu Xie,Yihan Chen,Li Zhang,Meiying Wu,Zhiting Deng,Yali Yang,Jing Wang,Qing Lv,Hairong Zheng,Mingxing Xie,Fei YanPubMed 31343564
- eLife 8:2019Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMroj Alassaf et. al.PubMed 31205004
- Frontiers in aging neuroscience 10:1862018Preventing P-gp Ubiquitination Lowers Aβ Brain Levels in an Alzheimer's Disease Mouse Model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnika M S Hartz et. al.PubMed 29997495
- Journal of virology 92:2018SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXinlong Luo et. al.PubMed 29643244
Key facts
- CAS number
- 59865-13-3
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 1202.6 Da
- Molecular formula
- C62H111N11O12
- PubChem identifier
- 5284373
- Nature
- Synthetic
Target data
Recommended products
MW 1202.6 Da, Purity >99%. Immunosuppressant. Complexes with cyclophilin to inhibit the phosphatase activity of calcineurin (PP2B). Please see CofA for batch specific MW.
Key facts
- CAS number
- 59865-13-3
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 1202.6 Da
- Molecular formula
- C62H111N11O12
- PubChem identifier
- 5284373
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 50 mM.
- Biochemical name
- cyclosporin A
- Biological description
Immunosuppressant. Complexes with cyclophilin to inhibit the phosphatase activity of calcineurin (PP2B). Please see CofA for batch specific MW.
- Canonical SMILES
- CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
- Isomeric SMILES
- CC[C@H]1C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
- InChI
- InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
- InChIKey
- PMATZTZNYRCHOR-CGLBZJNRSA-N
- IUPAC name
- (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - Cyclosporin A, PP2B inhibitor (ab120114)
2D chemical structure image of ab120114, Cyclosporin A, PP2B inhibitor
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