MW 389.9 Da, Purity >98%. Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Also available in Kit: Ionotropic agonists (ab120323).
Images
Publications
Filter by
- Frontiers in cellular neuroscience 12:5132019Electrophysiological Excitability and Parallel Fiber Synaptic Properties of Zebrin-Positive and -Negative Purkinje Cells in Lobule VIII of the Mouse Cerebellar Slice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesViet T Nguyen-Minh,Khoa Tran-Anh,Yuanjun Luo,Izumi SugiharaPubMed 30670950
- Biomedicine & pharmacotherapy = Biomedecine & phar 101:362-3702018GIRK1-mediated inwardly rectifying potassium current suppresses the epileptiform burst activities and the potential antiepileptic effect of ML297.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYian Huang et. al.PubMed 29499411
- Frontiers in molecular neuroscience 10:4022017Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWenyan Han et. al.PubMed 29276473
- The European journal of neuroscience 46:2519-25332017Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesCarissa D Winland et. al.PubMed 28921719
- Scientific reports 7:448172017Ca-permeable AMPA receptors in mouse olfactory bulb astrocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDamian Droste et. al.PubMed 28322255
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences 369:201306022014Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSimon Höft,Stephanie Griemsmann,Gerald Seifert,Christian SteinhäuserPubMed 25225096
- The Journal of neuroscience : the official journal of the Society for Neuroscience 34:11673-832014Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDavid Soto,Ian D Coombs,Esther Gratacòs-Batlle,Mark Farrant,Stuart G Cull-CandyPubMed 25164663
- The Journal of neuroscience : the official journal of the Society for Neuroscience 34:980-912014Photoinactivation of glutamate receptors by genetically encoded unnatural amino acids.Applications:Unspecified applicationReactive species:Unspecified reactive speciesViktoria Klippenstein,Valentina Ghisi,Marcus Wietstruk,Andrew J R PlestedPubMed 24431456
- Biochimica et biophysica acta 1833:1820-312013The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSalvatore Incontro et. al.PubMed 23545413
- Nature neuroscience 14:1430-82011Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarzieh Zonouzi et. al.PubMed 21983683
Key facts
- CAS number
- 2259-96-3
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 389.9 Da
- Molecular formula
- C14H16ClN3O4S2
- PubChem identifier
- 2910
- Nature
- Synthetic
Target data
Alternative names
AMPA 1, AMPA 2, AMPA 3, AMPA 4, AMPA-selective glutamate receptor 1, AMPA-selective glutamate receptor 2, AMPA-selective glutamate receptor 3, AMPA-selective glutamate receptor 4, GLUH1, GLUK3, GLUR4C, GRIA1_HUMAN, GRIA2_HUMAN, GRIA3_HUMAN, GRIA4_HUMAN, GluA 4, GluA1, GluA2, GluA3, GluR-1, GluR-2, GluR-3, GluR-4, GluR-A, GluR-B, GluR-C, GluR-D, GluR-K1, GluR-K2, GluR-K3, Glutamate ionotropic receptor AMPA type subunit 3, Glutamate receptor 1, Glutamate receptor 2, Glutamate receptor 3, Glutamate receptor 4, Glutamate receptor C, Glutamate receptor ionotrophic AMPA 3, Glutamate receptor ionotrophic AMPA 4, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, Glutamate receptor ionotropic AMPA 2, Glutamate receptor subunit 3, Glutamate receptor, ionotropic, AMPA 3, HBGR1, HBGR2, Ionotrophic Glutamate Receptor, Ionotropic Glutamate receptor 4, MGC133252, MRX94, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, dJ1171F9.1
Recommended products
MW 389.9 Da, Purity >98%. Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Also available in Kit: Ionotropic agonists (ab120323).
Key facts
- CAS number
- 2259-96-3
- Purity
- > 98%
- Form
- Solid
- Molecular weight
- 389.9 Da
- Molecular formula
- C14H16ClN3O4S2
- PubChem identifier
- 2910
- Nature
- Synthetic
- Solubility
Soluble in ethanol to 25 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- Cyclothiazide
- Biological description
Positive allosteric modulator of AMPA receptors. Produces a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current. Also available in Kit: Ionotropic agonists (ab120323).
- Canonical SMILES
- C1C2CC(C1C=C2)C3NC4=CC(=C(C=C4S(=O)(=O)N3)S(=O)(=O)N)Cl
- InChI
- InChI=1S/C14H16ClN3O4S2/c15-10-5-11-13(6-12(10)23(16,19)20)24(21,22)18-14(17-11)9-4-7-1-2-8(9)3-7/h1-2,5-9,14,17-18H,3-4H2,(H2,16,19,20)
- InChIKey
- BOCUKUHCLICSIY-UHFFFAOYSA-N
- IUPAC name
- 3-(2-bicyclo[2.2.1]hept-5-enyl)-6-chloro-1,1-dioxo-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Glutamate Receptor 1 also called AMPA receptor 1 is an ionotropic receptor that mediates fast synaptic transmission in the central nervous system. It is part of a larger family of glutamate receptors including subtypes GluA2 GluA3 and GluA4. The AMPA receptor structure typically forms a tetrameric complex mainly located in neuronal cells such as those in the hippocampus and cerebral cortex. The receptor has a mass of approximately 100 kDa. These receptors enable rapid excitatory signaling by allowing the flow of sodium (Na+) and calcium (Ca2+) ions into the cell upon binding glutamate.
- Biological function summary
The AMPA receptors facilitate neuronal communication and plasticity by modulating synaptic strength. This modulation occurs through processes such as potentiation and desensitisation where the receptor's response to glutamate changes. Potentiated sulfonamides like cyclothiazide can influence AMPA receptor activity by preventing desensitization maintaining prolonged neurotransmission. Cyclothiazide itself binds within the AMPA structure altering the conformation to prevent the desensitised state which is key in sustaining synaptic efficacy. AMPA receptors also interact with auxiliary proteins like TARPs (Transmembrane AMPA Receptor Regulatory Proteins) that assist in their trafficking and channel properties.
- Pathways
AMPA receptors play a significant role in the glutamatergic pathway integral for synaptic transmission and neuroplasticity. This pathway influences learning and memory processes. AMPA receptors also interact with the NMDA receptors in long-term potentiation (LTP) a process critical for memory formation and synaptic strength. Additionally they connect with proteins like CaMKII (Calcium/Calmodulin-dependent protein kinase II) during signal transduction processes inside neurons important for cellular responses following synaptic activation.
- Associated diseases and disorders
Abnormal AMPA receptor function associates with neurodegenerative conditions like Alzheimer’s disease and neurological disorders such as epilepsy. Dysregulation can lead to conditions characterized by excitotoxicity where excessive receptor activity causes neuronal damage. The abnormal interaction between AMPA receptors and proteins like the NMDA receptor may contribute to these conditions. Therapies targeting AMPA receptors aiming to modulate their activity present possible strategies for managing these diseases highlighting their importance on the AMPA receptors market.
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Chemical Structure - Cyclothiazide, AMPA receptor desensitisation inhibitor (ab120061)
2D chemical structure image of ab120061, Cyclothiazide, AMPA receptor desensitisation inhibitor
Image from Case DT, et al. Plos One, 6(6), e20756. Fig S4,; doi: 10.1371/journal.pone.0020756Cellular Activation - Cyclothiazide, AMPA receptor desensitisation inhibitor (ab120061)
To determine the capability of VCN-LSO synapses to support repetitive activity in the developing circuit, we added cyclothiazide to the perfusate to prevent AMPAR desensitization and measured responses to 50 Hz pulse-train stimuli delivered to the ventral acoustic stria. A. Representative responses to 50 Hz pulse-trains in P2, P5, and P9 cells; responses to the first five pulses only are shown. Greater paired-pulse depression between pulse 1 and 2 is evident in the youngest cell than in the older cells.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com