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AB120829

CyPPA, SK channel activator

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MW 285.39 g/mol, Purity >98%. First selective small conductance Ca2+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC50 values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.
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Chemical Structure - CyPPA, SK channel activator (AB120829)
  • Chemical Structure

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Chemical Structure - CyPPA, SK channel activator (AB120829)

2D chemical structure image of ab120829, CyPPA, SK channel activator

Key facts

CAS number

73029-73-9

Purity

>98%

Form

Solid

form

Molecular weight

285.39 g/mol

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>3</sub>N<sub>5</sub>

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 100 mM

Biological description

First selective small conductance Ca2+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC50 values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.

IUPAC Name

N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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