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MW 285.39 g/mol, Purity >98%. First selective small conductance Ca2+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC50 values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.

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Images

Chemical Structure - CyPPA, SK channel activator (AB120829), expandable thumbnail

Key facts

CAS number
73029-73-9
Purity
> 98%
Form
Solid
Molecular weight
285.39 g/mol
Molecular formula
C16H23N5
Nature
Synthetic

Target data

Recommended products

MW 285.39 g/mol, Purity >98%. First selective small conductance Ca2+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC50 values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.

Key facts

Purity
> 98%
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 100 mM.

Biological description

First selective small conductance Ca2+-activated K+ channel (SK) activator. Selectively opens SK2 and SK3 channels (EC50 values are 5.6 and 14 μM, respectively). Shows no activity at SK1 and IK. Additionally reduces activity and excitability of dopamine neurons. Active in vivo.

IUPAC name
N-Cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methyl-4-pyrimidinamine

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months

Product promise

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1 product image

  • Chemical Structure - CyPPA, SK channel activator (ab120829), expandable thumbnail

    Chemical Structure - CyPPA, SK channel activator (ab120829)

    2D chemical structure image of ab120829, CyPPA, SK channel activator

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Product protocols

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