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AB143482

Cytochalasin B, actin polymerization inhibitor

5

(1 Review)

|

(3 Publications)

MW 479.6 Da, Purity >97%. Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker (IC50 = 4 μM). Inhibits I(Kur). Cytochalasin A (ab143481) analog. Inhibits transport of monosaccharides across the cell membrane. Shows antitumor effects in vivo. .

View Alternative Names

AI838772, AW493413, Cytosolic NADP-isocitrate dehydrogenase, Epididymis luminal protein 216, Epididymis secretory protein Li 26, FLJ11090, HEL-216, HEL-S-26, ICDH, IDCD, IDH, IDH1, IDHC_HUMAN, IDP, IDPC, Isocitrate dehydrogenase (NADP(+)) 1 cytosolic, Isocitrate dehydrogenase 1 (NADP+) soluble, Isocitrate dehydrogenase [NADP] cytoplasmic, MGC104252, MGC112732, NADP dependent isocitrate dehydrogenase cytosolic, NADP dependent isocitrate dehydrogenase peroxisomal, NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, PICD, RP24-311F12.2, SCAN1, TYDP, TYDP1_HUMAN, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1

1 Images
Chemical Structure - Cytochalasin B, actin polymerization inhibitor (AB143482)
  • Chemical Structure

Lab

Chemical Structure - Cytochalasin B, actin polymerization inhibitor (AB143482)

2D chemical structure image of ab143482, Cytochalasin B, actin polymerization inhibitor

Key facts

CAS number

14930-96-2

Purity

>97%

Form

Solid

form

Source

Drechslera dematoidea

Molecular weight

479.6 Da

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>3</sub><sub>7</sub>NO<sub>5</sub>

PubChem

5311281

Nature

Native

Solubility

Soluble in DMSO to 10 mM

Biochemical name

Cytochalasin B

Biological description

Cell permeable actin polymerization inhibitor. Reversible KV1.5 blocker (IC50 = 4 μM). Inhibits I(Kur). Cytochalasin A (ab143481) analog. Inhibits transport of monosaccharides across the cell membrane. Shows antitumor effects in vivo.

Canonical smiles

CC1CCCC(C=CC(=O)OC23C(C=CC1)C(C(=C)C(C2C(NC3=O)CC4=CC=CC=C4)C)O)O

Isomeric smiles

C[C@@H]1CCC[C@H](/C=C/C(=O)O[C@]23[C@@H](/C=C/C1)[C@@H](C(=C)[C@H]([C@H]2[C@@H](NC3=O)CC4=CC=CC=C4)C)O)O

InChi

InChI=1S/C29H37NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14-16,18-19,22-24,26-27,31,33H,3,7,9-10,13,17H2,1-2H3,(H,30,34)/b14-8+,16-15+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

InChiKey

GBOGMAARMMDZGR-TYHYBEHESA-N

IUPAC Name

(1S,4E,6R,10R,12E,14S,15S,17S,18S,19S)-19-benzyl-6,15-dihydroxy-10,17-dimethyl-16-methylidene-2-oxa-20-azatricyclo[12.7.0.01,18]henicosa-4,12-diene-3,21-dione

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TDP1 also known as Tyrosyl-DNA phosphodiesterase 1 plays an important role in DNA repair. This enzyme has a molecular mass of approximately 68 kDa. TDP1 is expressed widely in human tissues predominantly in those with high cellular turnover like bone marrow and the gastrointestinal tract. It mechanistically splits the 3'-phosphotyrosyl bond between DNA and topoisomerase I resolving DNA-Protein cross-links that can otherwise interrupt DNA replication and transcription processes.
Biological function summary

This enzyme is involved in the repair of single-strand breaks by excising the protein residues linked to DNA particularly important for maintaining genome stability. TDP1 forms part of the DNA damage response machinery. In addition to its standalone function it interacts with various other proteins in the DNA repair complex. TDP1 works alongside other repair proteins such as PARP1 to address DNA lesions and maintain cellular integrity.

Pathways

TDP1 significantly contributes to the base excision repair pathway. It aids in counteracting the effects of topoisomerase I inhibitors which are often used in cancer therapy. TDP1 cooperates with SMARCA1 a chromatin remodeler to ensure efficient DNA repair and cellular recovery post-damage. Within this context TDP1's activity is important to both preserving cellular health and conferring resistance to DNA-damaging agents.

TDP1 has been linked to neurodegenerative diseases and certain forms of cancer. Mutations in TDP1 can lead to neurological disorders such as Spinocerebellar ataxia with axonal neuropathy (SCAN1) due to ineffective DNA repair. Additionally cancer cells can exploit increased TDP1 activity to resist chemotherapy highlighting its potential as a therapeutic target. Proteins like PARP1 and topoisomerase I are integral to these disease contexts operating in close association with TDP1 in response to DNA breakage and cellular stress.
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Product protocols

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

FEMS microbes 4:xtad019 PubMed37900578

2023

suppresses -induced NETosis and promotes bacterial survival in polymicrobial infections.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick Hsien-Neng Kao,Jun-Hong Ch'ng,Kelvin K L Chong,Claudia J Stocks,Siu Ling Wong,Kimberly A Kline

EMBO reports 22:e52006 PubMed34096155

2021

MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Wang,Xiaoping Chen,Haipeng Cheng,Lu Song,Jianghong Liu,Steve Caplan,Li Zhu,Jane Y Wu

Scientific reports 8:15585 PubMed30348987

2018

In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.

Applications

Unspecified application

Species

Unspecified reactive species

Kazuhide Takahashi,Yuri Miura,Ikuroh Ohsawa,Takuji Shirasawa,Mayumi Takahashi
View all publications
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