MW 507.6 Da, Purity >98%. Potent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable.
Images
Publications
Filter by
- Journal of virology 97:e00770232023Efficient clathrin-mediated entry of enteric adenoviruses in human duodenal cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMiriam Becker,Dario Valter Conca,Noemi Dorma,Nitesh Mistry,Elin Hahlin,Lars Frängsmyr,Marta Bally,Niklas Arnberg,Gisa GeroldPubMed 37823645
- FEMS microbes 4:xtad0192023suppresses -induced NETosis and promotes bacterial survival in polymicrobial infections.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPatrick Hsien-Neng Kao,Jun-Hong Ch'ng,Kelvin K L Chong,Claudia J Stocks,Siu Ling Wong,Kimberly A KlinePubMed 37900578
- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9:e21053652022Targeting the HDAC6-Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Ran,Yao Zhang,Sai Zhang,Haixia Li,Liang Zhang,Qingchao Li,Juan Qin,Dengwen Li,Lei Sun,Songbo Xie,Xiaomin Zhang,Lin Liu,Min Liu,Jun ZhouPubMed 35619548
- Frontiers in cell and developmental biology 10:8650562022Förster Resonance Energy Transfer-Based Single-Cell Imaging Reveals Piezo1-Induced Ca Flux Mediates Membrane Ruffling and Cell Survival.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHeon-Su Kim,Jung-Soo Suh,Yoon-Kwan Jang,Sang-Hyun Ahn,Gyu-Ho Choi,Jin-Young Yang,Gah-Hyun Lim,Youngmi Jung,Jie Jiang,Jie Sun,Myungeun Suk,Yingxiao Wang,Tae-Jin KimPubMed 35646889
- Pain 163:2138-21532022Altered pain sensitivity in 5×familial Alzheimer disease mice is associated with dendritic spine loss in anterior cingulate cortex pyramidal neurons.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhengyu Cui,Zhongzhao Guo,Luyao Wei,Xiang Zou,Zilu Zhu,Yuchen Liu,Jie Wang,Liang Chen,Deheng Wang,Zunji KePubMed 35384934
- Biomaterials translational 2:312-3222021Focal adhesion regulates osteogenic differentiation of mesenchymal stem cells and osteoblasts.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Zhao,Qing Sun,Bo HuoPubMed 35837413
- Scientific reports 11:178932021Distinct calcium regulation of TRPM7 mechanosensitive channels at plasma membrane microdomains visualized by FRET-based single cell imaging.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIrina Starostina,Yoon-Kwan Jang,Heon-Su Kim,Jung-Soo Suh,Sang-Hyun Ahn,Gyu-Ho Choi,Myungeun Suk,Tae-Jin KimPubMed 34504177
- Nature cell biology 23:733-7442021Cell fate coordinates mechano-osmotic forces in intestinal crypt formation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQiutan Yang,Shi-Lei Xue,Chii Jou Chan,Markus Rempfler,Dario Vischi,Francisca Maurer-Gutierrez,Takashi Hiiragi,Edouard Hannezo,Prisca LiberaliPubMed 34155381
- Frontiers in cellular and infection microbiology 10:6065412020Effector SpvB Disrupts Intestinal Epithelial Barrier Integrity for Bacterial Translocation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLanqing Sun et. al.PubMed 33392110
- Cell death & disease 11:4282020NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuangyun Wang et. al.PubMed 32513915
Key facts
- CAS number
22144-77-0
- Purity
> 98%
- Form
Solid
- Source
Zygosporium mansonii
- Molecular weight
507.6 Da
- Molecular formula
C30H37NO6
- PubChem identifier
5458428
- Nature
Native
Target data
Recommended products
MW 507.6 Da, Purity >98%. Potent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable.
Key facts
- CAS number
22144-77-0
- Purity
> 98%
- Form
Solid
- Source
Zygosporium mansonii
- Molecular weight
507.6 Da
- Molecular formula
C30H37NO6
- PubChem identifier
5458428
- Nature
Native
- Solubility
Soluble in ethanol to 10 mM. Soluble in DMSO to 50 mM.
- Biochemical name
cytochalasin D
- Biological description
Potent actin polymerization inhibitor. Binds to G- and F-actin. Stimulates actin depolymerization. Induces cell cycle arrest at G1-S. Activates p53-dependent pathways. Cell permeable.
- Canonical SMILES
CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O
- Isomeric SMILES
C[C@H]1C/C=C/[C@H]2[C@@H](C(=C)[C@H]([C@@H]3[C@@]2([C@@H](/C=C/[C@@](C1=O)(C)O)OC(=O)C)C(=O)N[C@H]3CC4=CC=CC=C4)C)O
- InChI
InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
- InChIKey
SDZRWUKZFQQKKV-JHADDHBZSA-N
- IUPAC name
[(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
1 product image
Chemical Structure - Cytochalasin D, actin polymerization inhibitor (ab143484)
2D chemical structure image of ab143484, Cytochalasin D, actin polymerization inhibitor
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com