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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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MW 432.5 Da, Purity >99%. γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable. 3D Growth matrix component and component of cerebral organoid differentiation media.
208255-80-5
> 99%
Solid
432.5 Da
C23H26F2N2O4
5311272
Synthetic
6530402N02Rik, AD3, AD3L, AD3LP, AD4, AD5, AL138795.3, APH 2, APH1A gamma secretase subunit, APH1A_HUMAN, ATAG1874, Ad3h, Alzheimer disease 4, Anterior Pharynx Defective 1, Anterior pharynx defective 1 homolog A, Anterior pharynx defective 2, Aph-1alpha, CGI 78, CMD1V, E5-1, FAD, Gamma Secretase Subunit PEN2, Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Hematopoietic stem/progenitor cells protein MDS033, Homo Sapiens Clone CC44 Senilin 1, KIAA0253, Likely ortholog of C. elegans anterior pharynx defective 1A, MDS033, MSTP064, NCT, NICA_HUMAN, Ncstn, Nicastrin, OTTHUMP00000035671, OTTHUMP00000035672, OTTHUMP00000228286, OTTHUMP00000228288, PEN2_HUMAN, PS-1, PS-2, PS1-CTF12, PSEN1, PSEN2, PSF, PSN1_HUMAN, PSN2_HUMAN, PSNL1, PSNL2, Presenilin 2, Presenilin 2 (Alzheimer disease 4), Presenilin Enhancer 2, Presenilin enhancer 2 homolog, Presenilin enhancer protein 2, Presenilin-1 CTF12, Presenilin-2 CTF subunit, Presenilin-stabilization factor, Protein S182, RP11 517F10.1, RP11517F101, S182, STM-2, UNQ579/PRO1141, psenen
MW 432.5 Da, Purity >99%. γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable. 3D Growth matrix component and component of cerebral organoid differentiation media.
6530402N02Rik, AD3, AD3L, AD3LP, AD4, AD5, AL138795.3, APH 2, APH1A gamma secretase subunit, APH1A_HUMAN, ATAG1874, Ad3h, Alzheimer disease 4, Anterior Pharynx Defective 1, Anterior pharynx defective 1 homolog A, Anterior pharynx defective 2, Aph-1alpha, CGI 78, CMD1V, E5-1, FAD, Gamma Secretase Subunit PEN2, Gamma-secretase subunit APH-1A, Gamma-secretase subunit PEN-2, Hematopoietic stem/progenitor cells protein MDS033, Homo Sapiens Clone CC44 Senilin 1, KIAA0253, Likely ortholog of C. elegans anterior pharynx defective 1A, MDS033, MSTP064, NCT, NICA_HUMAN, Ncstn, Nicastrin, OTTHUMP00000035671, OTTHUMP00000035672, OTTHUMP00000228286, OTTHUMP00000228288, PEN2_HUMAN, PS-1, PS-2, PS1-CTF12, PSEN1, PSEN2, PSF, PSN1_HUMAN, PSN2_HUMAN, PSNL1, PSNL2, Presenilin 2, Presenilin 2 (Alzheimer disease 4), Presenilin Enhancer 2, Presenilin enhancer 2 homolog, Presenilin enhancer protein 2, Presenilin-1 CTF12, Presenilin-2 CTF subunit, Presenilin-stabilization factor, Protein S182, RP11 517F10.1, RP11517F101, S182, STM-2, UNQ579/PRO1141, psenen
208255-80-5
> 99%
Solid
432.5 Da
C23H26F2N2O4
5311272
Synthetic
Dapt
γ-Secretase inhibitor. Inhibits Notch signalling in vitro. Inhibits total Aβ and Aβ42 production in human primary cultures (IC50 values are 115 and 200 nM, respectively) with no effect on APPα and APPβ levels. Blood-brain barrier permeable. 3D Growth matrix component and component of cerebral organoid differentiation media.
CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
DWJXYEABWRJFSP-XOBRGWDASA-N
tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Ambient - Can Ship with Ice
+4°C
The product can be stored for up to 12 months
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Full details and terms and conditions can be found here:
Terms & Conditions.
2D chemical structure image of ab120633, DAPT, gamma-Secretase inhibitor
ab81283 staining AKT1 (phospho S473) in MCF7 cells treated with DAPT (ab120633), by ICC/IF. Decrease in expression of AKT1 (phospho S473) correlates with increased concentration of DAPT, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120633 (DAPT) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab81283 (1/200 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Kc167 cells were treated with varying concentrations of DAPT (ab120633) in DMSO for 16hr at 25°C; DMSO only was used as the negative control. The cells were further incubated for 30 minutes with 4mM EGTA in PBS (in the presence of DAPT), and were then lysed for analysis. To measure Notch activity, Notch targets E(spl)mβ-HLH and E(spl)m3-HLH mRNA levels were assayed. Data shows the fold change of mRNA levels of E(spl)mβ-HLH and E(spl)m3-HLH under different conditions, normalised to DMSO treatment (negative control). Notch activation by EGTA is abrogated by treatment with DAPT.
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