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MW 340.4 Da, Purity >99%. Selective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. Decreases cancer cell growth and induces activation of caspases 3 and 7.

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Images

Chemical Structure - DBeQ, p97 ATPase inhibitor (AB141254), expandable thumbnail

Publications

Key facts

CAS number

177355-84-9

Purity

> 99%

Form

Solid

Molecular weight

340.4 Da

Molecular formula

C22H20N4

PubChem identifier

676352

Nature

Synthetic

Target data

Alternative names

15S Mg(2+)-ATPase p97 subunit, ALS14, ATPase p97, Beta-interferon, CDC48, DNA repair protein RAD52, DNA repair protein RAD52 homolog, Fibroblast interferon, IBMPFD, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, MGC131997, MGC148092, MGC8560, MGC96956, P97, RAD52 homolog, RAD52 homolog (S. cerevisiae), RAD52_HUMAN, Recombination protein RAD52, Rhabdomyosarcoma antigen MU RMS 40.23, TER ATPase, TERA_HUMAN, Transitional endoplasmic reticulum ATPase, Valosin-containing protein, Yeast Cdc48p homolog

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MW 340.4 Da, Purity >99%. Selective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. Decreases cancer cell growth and induces activation of caspases 3 and 7.

Key facts

Purity

> 99%

PubChem identifier

676352

Solubility

Soluble in DMSO to 100 mM. Soluble in ethanol to 20 mM.

Biochemical name

N2,N4-dibenzylquinazoline-2,4-diamine

Biological description

Selective, potent, reversible and ATP-competitive p97 ATPase inhibitor (IC50 = 1.5 μM). Inhibits a number of cellular processes including ER-associated degradation, ubiquitin fusion degradation and autophagosome maturation. Decreases cancer cell growth and induces activation of caspases 3 and 7.

Canonical SMILES

C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4

InChI

InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChIKey

QAIMUUJJAJBPCL-UHFFFAOYSA-N

IUPAC name

2-N,4-N-dibenzylquinazoline-2,4-diamine

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

+4°C

Storage information

The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Interferon beta also known as IFN-β is a cytokine with a molecular weight of approximately 20 kDa. In humans this protein is predominantly expressed in fibroblasts and certain leukocytes. As a member of the interferon family IFN-β plays a significant role in modulating immune responses and exhibits antiviral antiproliferative and immunomodulatory activities. IFN-β production can be triggered by viral infections or other stimuli engaging its receptor complexes to facilitate downstream signaling pathways.

Biological function summary

Interferon beta takes part in immune regulation and defense against pathogens. It often works in tandem with other type I interferons and components of the immune system. Its involvement in the JAK-STAT signaling pathway illustrates its role in transcriptional regulation of antiviral proteins and mediators of inflammation. These interactions emphasize its value in maintaining cellular homeostasis and response to pathogens by facilitating communication within the immune system network.

Pathways

Interferon beta is deeply involved in the innate and adaptive immune response signaling pathways. It engages with the JAK-STAT pathway which ties it to proteins like STAT1 and STAT2 influencing gene expression related to antiviral states and immune modulation. Additionally its role in the interferon signaling pathway highlights its importance in inducing a robust antiviral state in cells where it can interact with IFNAR1 and IFNAR2 to propagate immune signals.

Associated diseases and disorders

Interferon beta plays a significant role in multiple sclerosis (MS) by modulating immune system activity and reducing inflammation. It can influence disease progression and patient outcomes when used therapeutically. Additionally its antiviral properties are valuable in managing some viral infections where it helps limit the replication and spread of viruses. Through these pathways IFN-β is also connected with other proteins such as TNF-α which is involved in inflammatory mediation in autoimmunity and infection-related conditions.

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1 product image

  • Chemical Structure - DBeQ, p97 ATPase inhibitor (ab141254), expandable thumbnail

    Chemical Structure - DBeQ, p97 ATPase inhibitor (ab141254)

    2D chemical structure image of ab141254, DBeQ, p97 ATPase inhibitor

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Product protocols

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