MW 656.8 Da. Iron chelator. Blood-brain barrier permeable. Displays a number of biological actions such as immunomodulation, inhibition of inflammation and atherosclerosis, and reduction of neuronal death.
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- Cell death discovery 9:4562023Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBinjie Yan,Darrell Belke,Yu Gui,Yong-Xiang Chen,Zhi-Sheng Jiang,Xi-Long ZhengPubMed 38097554
- Cell death & disease 13:6622022Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoshiyuki Henning,Ursula Sarah Blind,Safa Larafa,Johann Matschke,Joachim FandreyPubMed 35906211
- Journal of experimental & clinical cancer research : CR 40:3502021PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJi Hyeon You,Jaewang Lee,Jong-Lyel RohPubMed 34749765
- Oncology letters 20:2689-27002020xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAkiko Sugiyama et. al.PubMed 32782585
- JCI insight 5:2020Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTomonori Tadokoro et. al.PubMed 32376803
- The Journal of biological chemistry 295:7060-70742020The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChangying Fu et. al.PubMed 32277050
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 57:1264062019Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJyotirmoy Rakshit,Ayushi Priyam,Karthik Kumar Gowrishetty,Sudhanshu Mishra,Jaya BandyopadhyayPubMed 31570251
- Life sciences 203:276-2812018Type 3 iodothyronine deiodinase is expressed in human induced pluripotent stem cell derived cardiomyocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKumiko Nishimura,Masafumi Takeda,Jun K Yamashita,Ichiro Shiojima,Nagaoki ToyodaPubMed 29684447
- Journal of controlled release : official journal o 279:69-782018Mesoporous silicate nanoparticles/3D nanofibrous scaffold-mediated dual-drug delivery for bone tissue engineering.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQingqing Yao et. al.PubMed 29649529
- Pharmacology research & perspectives 5:e002832017Chronic diazepam administration increases the expression of Lcn2 in the CNS.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTomonori Furukawa et. al.PubMed 28596835
Key facts
- CAS number
138-14-7
- Form
Solid
- Molecular weight
656.8 Da
- Molecular formula
C26H52N6O11S
- PubChem identifier
62881
- Nature
Synthetic
Recommended products
MW 656.8 Da. Iron chelator. Blood-brain barrier permeable. Displays a number of biological actions such as immunomodulation, inhibition of inflammation and atherosclerosis, and reduction of neuronal death.
Key facts
- CAS number
138-14-7
- Form
Solid
- Molecular weight
656.8 Da
- Molecular formula
C26H52N6O11S
- PubChem identifier
62881
- Nature
Synthetic
- Solubility
Soluble in water to 100 mM.
- Biochemical name
Deferoxamine mesylate
- Biological description
Iron chelator. Blood-brain barrier permeable. Displays a number of biological actions such as immunomodulation, inhibition of inflammation and atherosclerosis, and reduction of neuronal death.
- Canonical SMILES
CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O
- InChI
InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
- InChIKey
IDDIJAWJANBQLJ-UHFFFAOYSA-N
- IUPAC name
N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
-20°C
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions, The product can be stored for up to 12 months
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4 product images
Chemical Structure - Deferoxamine mesylate, Iron chelator (ab120727)
2D chemical structure image of ab120727, Deferoxamine mesylate, Iron chelator
Functional Studies - Deferoxamine mesylate, Iron chelator (ab120727)
Titration of HeLa-DFO extract within the working range of the assay. Background subtracted data from duplicate measurements are plotted. To induce HIF1 alpha protein levels, HeLa cells were treated with 500 µM DFO (ab120727) for 24 hours.
Functional Studies - Deferoxamine mesylate, Iron chelator (ab120727)
Dose-dependent induction of HIF1 alpha in HeLa cells by DFO (ab120727). HeLa cells were cultured in 96-well tissue culture plates and were either untreated or exposed to varying dose of DFO for 24 hours. Raw data with standard deviation is plotted from triplicate measurements.
Functional Studies - Deferoxamine mesylate, Iron chelator (ab120727)
Comparison of HIF1 alpha expression in HeLa cell extracts (with and without DFO treatment) by SimpleStep ELISA (barchart) and western blot (top). Background subtracted OD450 nm data from three loading concentrations are shown. The HIF1 alpha detector antibody was used to blot the same lysates as analyzed by SimpleStep ELISA (40 µg loaded/lane). The GAPDH blot is included to show the relative loads of each lysate. In the HeLa cell line, DFO treatment is required to detect HIF1 alpha protein by both SimpleStep ELISA and western blot.
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