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AB120727

Deferoxamine mesylate, Iron chelator

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(14 Publications)

MW 656.8 Da. Iron chelator. Blood-brain barrier permeable. Displays a number of biological actions such as immunomodulation, inhibition of inflammation and atherosclerosis, and reduction of neuronal death.
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Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)
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Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)

Comparison of HIF1 alpha expression in HeLa cell extracts (with and without DFO treatment) by SimpleStep ELISA (barchart) and western blot (top). Background subtracted OD450 nm data from three loading concentrations are shown. The HIF1 alpha detector antibody was used to blot the same lysates as analyzed by SimpleStep ELISA (40 µg loaded/lane). The GAPDH blot is included to show the relative loads of each lysate. In the HeLa cell line, DFO treatment is required to detect HIF1 alpha protein by both SimpleStep ELISA and western blot.

Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)
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Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)

Dose-dependent induction of HIF1 alpha in HeLa cells by DFO (ab120727). HeLa cells were cultured in 96-well tissue culture plates and were either untreated or exposed to varying dose of DFO for 24 hours. Raw data with standard deviation is plotted from triplicate measurements.

Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)
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Functional Studies - Deferoxamine mesylate, Iron chelator (AB120727)

Titration of HeLa-DFO extract within the working range of the assay. Background subtracted data from duplicate measurements are plotted. To induce HIF1 alpha protein levels, HeLa cells were treated with 500 µM DFO (ab120727) for 24 hours.

Chemical Structure - Deferoxamine mesylate, Iron chelator (AB120727)
  • Chemical Structure

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Chemical Structure - Deferoxamine mesylate, Iron chelator (AB120727)

2D chemical structure image of ab120727, Deferoxamine mesylate, Iron chelator

Key facts

CAS number

138-14-7

Form

Solid

form

Molecular weight

656.8 Da

Molecular formula

C<sub>2</sub><sub>6</sub>H<sub>5</sub><sub>2</sub>N<sub>6</sub>O<sub>1</sub><sub>1</sub>S

PubChem

62881

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Deferoxamine mesylate

Biological description

Iron chelator. Blood-brain barrier permeable. Displays a number of biological actions such as immunomodulation, inhibition of inflammation and atherosclerosis, and reduction of neuronal death.

Canonical smiles

CC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCNC(=O)CCC(=O)N(CCCCCN)O)O)O.CS(=O)(=O)O

InChi

InChI=1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)

InChiKey

IDDIJAWJANBQLJ-UHFFFAOYSA-N

IUPAC Name

N-[5-[[4-[5-[acetyl(hydroxy)amino]pentylamino]-4-oxobutanoyl]-hydroxyamino]pentyl]-N'-(5-aminopentyl)-N'-hydroxybutanediamide;methanesulfonic acid

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Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
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Biochemicals

AB120487

Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor

Functional Studies - Z-VAD(OMe)-FMK, Cell permeable, irreversible pan-caspase inhibitor (AB120487)

  • 0
  • 0
Assay Kits

AB239715

Total Iron-Binding Capacity (TIBC) and Serum Iron Assay Kit

Functional Studies - Total Iron-Binding Capacity (TIBC) and Serum Iron Assay Kit (AB239715)

  • 4
  • 3
Assay Kits

AB83366

Iron Assay Kit (Colorimetric)

Biochemical assay - Iron Assay Kit (Colorimetric) (AB83366)

  • 4
  • 3
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 135: PubMed40591405

2025

Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Kodai Nakamura,Huascar Pedro Ortuste Quiroga,Naoki Horii,Shin Fujimaki,Toshiro Moroishi,Keiichi I Nakayama,Shinjiro Hino,Yoshihiko Saito,Ichizo Nishino,Yusuke Ono

BMC pregnancy and childbirth 25:21 PubMed39789492

2025

High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Wei-Jian Zeng,Hua-Jing Yang,Ying-Jie Gu,Meng-Nan Yang,Meng-Ru Sun,Sheng-Kai Cheng,Yan-Yan Hou,Wei Gu

Cell death discovery 9:456 PubMed38097554

2023

Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cells.

Applications

Unspecified application

Species

Unspecified reactive species

Binjie Yan,Darrell Belke,Yu Gui,Yong-Xiang Chen,Zhi-Sheng Jiang,Xi-Long Zheng

Molecular & cellular proteomics : MCP 23:100691 PubMed38072118

2023

Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron Efflux.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Che,Qingsong Wang,Minzhe Li,Jian Shen,Jianguo Ji

Cell death & disease 13:662 PubMed35906211

2022

Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reaction.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiyuki Henning,Ursula Sarah Blind,Safa Larafa,Johann Matschke,Joachim Fandrey

Journal of experimental & clinical cancer research : CR 40:350 PubMed34749765

2021

PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hyeon You,Jaewang Lee,Jong-Lyel Roh

Oncology letters 20:2689-2700 PubMed32782585

2020

xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Akiko Sugiyama,Tsuyoshi Ohta,Miyuki Obata,Kanako Takahashi,Manabu Seino,Satoru Nagase

JCI insight 5: PubMed32376803

2020

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Tomonori Tadokoro,Masataka Ikeda,Tomomi Ide,Hiroko Deguchi,Soichiro Ikeda,Kosuke Okabe,Akihito Ishikita,Shouji Matsushima,Tomoko Koumura,Ken-Ichi Yamada,Hirotaka Imai,Hiroyuki Tsutsui

The Journal of biological chemistry 295:7060-7074 PubMed32277050

2020

The transcription factor ZFHX3 is crucial for the angiogenic function of hypoxia-inducible factor 1α in liver cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Changying Fu,Na An,Jinming Liu,Jun A,Baotong Zhang,Mingcheng Liu,Zhiqian Zhang,Liya Fu,Xinxin Tian,Dan Wang,Jin-Tang Dong

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 57:126406 PubMed31570251

2019

Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Jyotirmoy Rakshit,Ayushi Priyam,Karthik Kumar Gowrishetty,Sudhanshu Mishra,Jaya Bandyopadhyay
View all publications
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