JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB142418

Dehydrocostus lactone, Cell proliferation inhibitor

Be the first to review this product! Submit a review

|

(1 Publication)

MW 230.3 Da, Purity >98%. Cell proliferation inhibitor, induces cell cycle arrest and apoptosis. Inhibits NO synthase and TNF-α in LPS-activated macrophages. Cytotoxic T lymphocyte inhibitor in vitro (IC50 = 10 μM). Guaianolide. Immunomodulator and antitumor agent. Active in vivo and in vitro.
1 Images
Chemical Structure - Dehydrocostus lactone, Cell proliferation inhibitor (AB142418)
  • Chemical Structure

Lab

Chemical Structure - Dehydrocostus lactone, Cell proliferation inhibitor (AB142418)

2D chemical structure image of ab142418, Dehydrocostus lactone, Cell proliferation inhibitor

Key facts

CAS number

477-43-0

Purity

>98%

Form

Solid

form

Molecular weight

230.3 Da

Molecular formula

C<sub>1</sub><sub>5</sub>H<sub>1</sub><sub>8</sub>O<sub>2</sub>

PubChem

73174

Nature

Synthetic

Solubility

Soluble in DMSO to 75 mM

Biochemical name

Dehydrocostus lactone

Biological description

Cell proliferation inhibitor, induces cell cycle arrest and apoptosis. Inhibits NO synthase and TNF-α in LPS-activated macrophages. Cytotoxic T lymphocyte inhibitor in vitro (IC50 = 10 μM). Guaianolide. Immunomodulator and antitumor agent. Active in vivo and in vitro.

Canonical smiles

C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C

Isomeric smiles

C=C1CC[C@@H]2[C@@H]([C@@H]3[C@H]1CCC3=C)OC(=O)C2=C

InChi

InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h11-14H,1-7H2/t11-,12-,13-,14-/m0/s1

InChiKey

NETSQGRTUNRXEO-XUXIUFHCSA-N

IUPAC Name

(3aS,6aR,9aR,9bS)-3,6,9-trimethylidene-3a,4,5,6a,7,8,9a,9b-octahydroazuleno[4,5-b]furan-2-one

style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International immunopharmacology 22:332-40 PubMed25066549

2014

Dehydrocostuslactone inhibits LPS-induced inflammation by p38MAPK-dependent induction of hemeoxygenase-1 in vitro and improves survival of mice in CLP-induced sepsis in vivo.

Applications

Unspecified application

Species

Unspecified reactive species

Eun Jung Park,Sang Won Park,Hye Jung Kim,Jong-Hwan Kwak,Dong-Ung Lee,Ki Churl Chang
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Assay Kits

AB287852

Cell Cycle Analysis Kit

Functional Studies - Cell Cycle Analysis Kit (AB287852)

  • 0
  • 0
Assay Kits

AB112117

Cell Cycle Assay Kit (Fluorometric - Red)

Flow Cytometry - Cell Cycle Assay Kit (Fluorometric - Red) (AB112117)

  • 0
  • 0
Biochemicals

AB144296

Malformin C, cell cycle G2 arrest inhibitor

Chemical Structure - Malformin C, cell cycle G2 arrest inhibitor (AB144296)

  • 0
  • 0
Primary Antibodies

AB32072

Anti-c-Myc antibody [Y69] - ChIP Grade

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Myc antibody [Y69] - ChIP Grade (AB32072)

  • 4
  • 56

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com