MW 392.5 Da, Purity >99%. Anti-inflammatory glucocorticoid (IC50 = 38 nM and Ki = 6.7 nM for the glucocorticoid receptor). Displays 7-fold higher affinity for glucocorticoid receptors than hydrocortisone. Long-term effects following oral administration. Used in the generation of liver organoids.
Images
Publications
Filter by
- Acta pharmaceutica Sinica. B 12:1899-19122022Disruption of adipocyte HIF-1 improves atherosclerosis through the inhibition of ceramide generation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPengcheng Wang,Guangyi Zeng,Yu Yan,Song-Yang Zhang,Yongqiang Dong,Yangming Zhang,Xingzhong Zhang,Huiying Liu,Zhipeng Zhang,Changtao Jiang,Yanli PangPubMed 35847503
- Clinical immunology (Orlando, Fla.) 155:126-1352014Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHannah H Walford et. al.PubMed 25236785
Key facts
- CAS number
- 50-02-2
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 392.5 Da
- Molecular formula
- C22H29FO5
- PubChem identifier
- 5743
- Nature
- Synthetic
Target data
Alternative names
(R)-limonene 6-monooxygenase, (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase, ABC 35, ABCC 7, ATP Binding Cassette Superfamily C Member 7, ATP binding cassette transporter sub family C member 7, ATP-binding cassette sub-family C member 7, Avian reticuloendotheliosis viral (v rel) oncogene homolog A, BAR, BXR, Bile acid receptor, CF, CFTR/MRP, CFTR_HUMAN, CIMT1, CP2C9_HUMAN, CP2D6_HUMAN, CPC9, CPD6, CYP2C, CYP2C10, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIIC9, CYPIID6, Channel conductance-controlling ATPase, Cholesterol 25-hydroxylase, Cystic Fibrosis Transmembrane Regulator, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7), Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7, Cytochrome P-450MP, Cytochrome P450 2C9, Cytochrome P450 2D6, Cytochrome P450 MP-4, Cytochrome P450 MP-8, Cytochrome P450 PB-1, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450, family 2, subfamily C, polypeptide 9, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, FABP 1, FABPL_HUMAN, FXR, Farnesoid X receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Fatty acid binding protein 1 liver, Fatty acid-binding protein, Fatty acid-binding protein 1, Fatty acid-binding protein liver, GLM1, HRR 1, L-FABP, Liver-type fatty acid-binding protein, MGC131774, MGC149605, MGC88320, Microsomal monooxygenase, NF kappa B p65delta3, NFKB3, NFkB p65, NR1C3, NR1H4_HUMAN, NR1I2_HUMAN, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor kappa-B, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, Nuclear receptor subfamily 1 group C member 3, Nuclear receptor subfamily 1 group H member 4, Nuclear receptor subfamily 1 group I member 2, ONR 1, OTTHUMP00000020135, OTTHUMP00000185032, OTTHUMP00000185036, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, OTTHUMP00000233473, OTTHUMP00000233474, OTTHUMP00000233475, OTTHUMP00000233476, OTTHUMP00000233900, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, P450 DB1, P450 MP, P450 PB 1, P450C2D, P450IIC9, PAR, PAR q, PPAR-gamma, PPARG1, PPARG2, PPARG_HUMAN, PRR, Peroxisome proliferator activated nuclear receptor gamma variant 1, Peroxisome proliferator activated receptor gamma 1, Peroxisome proliferator-activated receptor gamma, Pregnane X receptor, RIP 14, RXR-interacting protein 14, Retinoid X receptor-interacting protein 14, S-mephenytoin 4-hydroxylase, SXR, Steroid and xenobiotic receptor, TF65_HUMAN, TNR CFTR, Transcription factor NFKB3, Transcription factor p65, V rel avian reticuloendotheliosis viral oncogene homolog A, V rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65, Xenobiotic monooxygenase, cAMP-dependent chloride channel, cytochrome P-450 S-mephenytoin 4-hydroxylase, dJ760C5.1, flavoprotein-linked monooxygenase, nfkappabp65, p65, p65 NF kappaB, p65 NFkB, pregnane X nuclear receptor variant 2, relA, v rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)), v rel reticuloendotheliosis viral oncogene homolog A (avian)
Recommended products
MW 392.5 Da, Purity >99%. Anti-inflammatory glucocorticoid (IC50 = 38 nM and Ki = 6.7 nM for the glucocorticoid receptor). Displays 7-fold higher affinity for glucocorticoid receptors than hydrocortisone. Long-term effects following oral administration. Used in the generation of liver organoids.
Key facts
- CAS number
- 50-02-2
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 392.5 Da
- Molecular formula
- C22H29FO5
- PubChem identifier
- 5743
- Nature
- Synthetic
- Biochemical name
- Dexamethasone
- Biological description
Anti-inflammatory glucocorticoid (IC50 = 38 nM and Ki = 6.7 nM for the glucocorticoid receptor). Displays 7-fold higher affinity for glucocorticoid receptors than hydrocortisone. Long-term effects following oral administration. Used in the generation of liver organoids.
- Canonical SMILES
- CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
- Isomeric SMILES
- C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
- InChI
- InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
- InChIKey
- UREBDLICKHMUKA-CXSFZGCWSA-N
- IUPAC name
- (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions
Product promise
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
3 product images
Chemical Structure - Dexamethasone, anti-inflammatory glucocorticoid (ab120743)
2D chemical structure image of ab120743, Dexamethasone, anti-inflammatory glucocorticoid
Functional Studies - Dexamethasone, anti-inflammatory glucocorticoid (ab120743)
ab75974 staining p57 Kip2 in HeLa cells treated with dexamethasone (ab120743), by ICC/IF. Increase in p57 Kip2 expression correlates with increased concentration of dexamethasone as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120743 (dexamethasone) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab75974 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Functional Studies - Dexamethasone, anti-inflammatory glucocorticoid (ab120743)
1e7 3T3-L1 cells were treated for 15 minutes with 1 µM dexamethasone (ab120743) and 1 µg x mL-1 insulin (Recombinant human Insulin protein (Active) ab123768) with the addition of 50 µM forskolin (Forskolin, Adenylyl cyclase activator ab120058), 0.5 mM IBMX (IBMX, Non-specific cAMP and cGMP inhibitor ab120840) or 0.1 mM 8-CPT-cAMP (8-(4-Chlorophenylthio)adenosine 3',5'-cyclic monophosphate (8-CPT-cAMP), Cell permeable cAMP analog. ab120424), extracted according to the protocol. Lysates were diluted 50-fold, and tested in duplicates (+/-SD).
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com