Dextromethorphan hydrobromide, NMDA receptor antagonist

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Glutamate Receptor 1 also known as AMPA receptor GluA1 or GRIA1 is an important component of the fast excitatory synaptic transmission in the central nervous system. This receptor subunit weighs approximately 100 kDa and is found in high concentration in the brain particularly in areas like the hippocampus and cortex. Functionally GRIA1 facilitates synaptic plasticity and the transmission of excitatory signals by controlling calcium permeability through AMPA receptor channels.

Biological function summary

The Glutamate Receptor 1 plays a significant role as part of the ionotropic glutamate receptor complex. It interacts with other subunits such as GluA2 to form homomeric or heteromeric assemblies that determine the receptor's permeability and kinetics. The activation of these receptor complexes influences learning and memory processes through long-term potentiation (LTP) and long-term depression (LTD) in neurons.

Pathways

The Glutamate Receptor 1 is integral to the glutamatergic signaling pathway which is essential for neuronal communication. This pathway involves the activation of AMPA receptors which work in concert with NMDA receptors to modulate synaptic strength. GRIA1 also associates with proteins like Stargazin an auxiliary subunit that influences receptor localization and trafficking playing a vital role in synaptic function and plasticity.

Associated diseases and disorders

The malfunction of the Glutamate Receptor 1 has associations with neurological conditions such as epilepsy and schizophrenia. Alterations in GRIA1 expression or function can contribute to the synaptic anomalies observed in these disorders. Similarly GRIA1's interaction with other proteins like SynGAP implicated in the regulation of synaptic signaling highlights its involvement in neurodevelopmental and psychiatric conditions.