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AB141028

Dextromethorphan hydrobromide, NMDA receptor antagonist

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MW 370.3 Da, Purity >99%. Non-competitive, low affinity NMDA receptor antagonist. Displays antitussive and neuroprotective effects. Active in vivo.

Also available in simple stock solutions (ab146729) - add 1 ml of water to get an exact, ready-to-use concentration.

View Alternative Names

AMPA 1, AMPA-selective glutamate receptor 1, CP2D6_HUMAN, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, Cholesterol 25-hydroxylase, Cytochrome P450 2D6, Cytochrome P450 family 2 subfamily D member 6, Cytochrome P450 family 2 subfamily D polypeptide 6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, Microsomal monooxygenase, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243, P450 DB1, P450C2D, Xenobiotic monooxygenase, flavoprotein-linked monooxygenase

1 Images
Chemical Structure - Dextromethorphan hydrobromide, NMDA receptor antagonist (AB141028)
  • Chemical Structure

Lab

Chemical Structure - Dextromethorphan hydrobromide, NMDA receptor antagonist (AB141028)

2D chemical structure image of ab141028, Dextromethorphan hydrobromide, NMDA receptor antagonist

Key facts

CAS number

6700-34-1

Purity

>99%

Form

Solid

form

Molecular weight

370.3 Da

Molecular formula

C<sub>1</sub><sub>8</sub>H<sub>2</sub><sub>8</sub>BrNO<sub>2</sub>

PubChem

5462351

Nature

Synthetic

Solubility

Soluble in water to 50 mM

Soluble in ethanol to 100 mM

Biochemical name

Dextromethorphan hydrobromide

Biological description

Non-competitive, low affinity NMDA receptor antagonist. Displays antitussive and neuroprotective effects. Active in vivo.

Also available in simple stock solutions (ab146729) - add 1 ml of water to get an exact, ready-to-use concentration.

Canonical smiles

CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)OC.O.Br

Isomeric smiles

CN1CC[C@@]23CCCC[C@@H]2[C@@H]1CC4=C3C=C(C=C4)OC.O.Br

InChi

InChI=1S/C18H25NO.BrH.H2O/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18;;/h6-7,12,15,17H,3-5,8-11H2,1-2H3;1H;1H2/t15-,17+,18+;;/m1../s1

InChiKey

STTADZBLEUMJRG-IKNOHUQMSA-N

IUPAC Name

(1S,9S,10S)-4-methoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene;hydrate;hydrobromide

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glutamate Receptor 1 also known as AMPA receptor GluA1 or GRIA1 is an important component of the fast excitatory synaptic transmission in the central nervous system. This receptor subunit weighs approximately 100 kDa and is found in high concentration in the brain particularly in areas like the hippocampus and cortex. Functionally GRIA1 facilitates synaptic plasticity and the transmission of excitatory signals by controlling calcium permeability through AMPA receptor channels.
Biological function summary

The Glutamate Receptor 1 plays a significant role as part of the ionotropic glutamate receptor complex. It interacts with other subunits such as GluA2 to form homomeric or heteromeric assemblies that determine the receptor's permeability and kinetics. The activation of these receptor complexes influences learning and memory processes through long-term potentiation (LTP) and long-term depression (LTD) in neurons.

Pathways

The Glutamate Receptor 1 is integral to the glutamatergic signaling pathway which is essential for neuronal communication. This pathway involves the activation of AMPA receptors which work in concert with NMDA receptors to modulate synaptic strength. GRIA1 also associates with proteins like Stargazin an auxiliary subunit that influences receptor localization and trafficking playing a vital role in synaptic function and plasticity.

The malfunction of the Glutamate Receptor 1 has associations with neurological conditions such as epilepsy and schizophrenia. Alterations in GRIA1 expression or function can contribute to the synaptic anomalies observed in these disorders. Similarly GRIA1's interaction with other proteins like SynGAP implicated in the regulation of synaptic signaling highlights its involvement in neurodevelopmental and psychiatric conditions.
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Product protocols

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