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AB120621

Diclofenac sodium salt, cyclo-oxygenase inhibitor

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(1 Publication)

MW 318.13 g/mol, Purity >99%. Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2, respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, antipyretic and analgesic effects.
2 Images
Immunocytochemistry/ Immunofluorescence - Diclofenac sodium salt, cyclo-oxygenase inhibitor (AB120621)
  • ICC/IF

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Immunocytochemistry/ Immunofluorescence - Diclofenac sodium salt, cyclo-oxygenase inhibitor (AB120621)

ab96732 staining Prostaglandin dehydrogenase 1 in MCF7 cells treated with diclofenac sodium salt (ab120621), by ICC/IF. Increase in Prostaglandin dehydrogenase 1 expression correlates with increased concentration of diclofenac sodium salt as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120621 (diclofenac sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96732 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - Diclofenac sodium salt, cyclo-oxygenase inhibitor (AB120621)
  • Chemical Structure

Lab

Chemical Structure - Diclofenac sodium salt, cyclo-oxygenase inhibitor (AB120621)

2D chemical structure image of ab120621, Diclofenac sodium salt, cyclo-oxygenase inhibitor

Key facts

CAS number

15307-79-6

Purity

>99%

Form

Solid

form

Molecular weight

318.13 g/mol

Molecular formula

C<sub>1</sub><sub>4</sub>H<sub>1</sub><sub>0</sub>Cl<sub>2</sub>NNaO<sub>2</sub>

Nature

Synthetic

Solubility

Soluble in water to 50 mM (at room temperature) and in water to 100 mM (with warming)

Biological description

Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2, respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, antipyretic and analgesic effects.

IUPAC Name

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Biochemical pharmacology 154:318-334 PubMed29800556

2018

Celecoxib inhibits mitochondrial O consumption, promoting ROS dependent death of murine and human metastatic cancer cells via the apoptotic signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Rhys Pritchard,Sara Rodríguez-Enríquez,Silvia Cecilia Pacheco-Velázquez,Vuk Bortnik,Rafael Moreno-Sánchez,Stephen Ralph
View all publications
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