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MW 318.13 g/mol, Purity >99%. Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2, respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, antipyretic and analgesic effects.

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Images

Chemical Structure - Diclofenac sodium salt, cyclo-oxygenase inhibitor (AB120621), expandable thumbnail
  • Immunocytochemistry/ Immunofluorescence - Diclofenac sodium salt, cyclo-oxygenase inhibitor (AB120621), expandable thumbnail

Publications

Key facts

CAS number

15307-79-6

Purity

> 99%

Form

Solid

Molecular weight

318.13 g/mol

Molecular formula

C14H10Cl2NNaO2

Nature

Synthetic

Target data

Recommended products

MW 318.13 g/mol, Purity >99%. Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2, respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, antipyretic and analgesic effects.

Key facts

Purity

> 99%

Solubility

Soluble in water to 50 mM (at room temperature) and in water to 100 mM (with warming).

Biological description

Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2, respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, antipyretic and analgesic effects.

IUPAC name

2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate short-term storage conditions

Ambient

Appropriate long-term storage conditions

Ambient

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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2 product images

  • Chemical Structure - Diclofenac sodium salt, cyclo-oxygenase inhibitor (ab120621), expandable thumbnail

    Chemical Structure - Diclofenac sodium salt, cyclo-oxygenase inhibitor (ab120621)

    2D chemical structure image of ab120621, Diclofenac sodium salt, cyclo-oxygenase inhibitor

  • Immunocytochemistry/ Immunofluorescence - Diclofenac sodium salt, cyclo-oxygenase inhibitor (ab120621), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Diclofenac sodium salt, cyclo-oxygenase inhibitor (ab120621)

    Anti-15-PGDH antibody ab96732 staining Prostaglandin dehydrogenase 1 in MCF7 cells treated with diclofenac sodium salt (ab120621), by ICC/IF. Increase in Prostaglandin dehydrogenase 1 expression correlates with increased concentration of diclofenac sodium salt as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120621 (diclofenac sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-15-PGDH antibody ab96732 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody.

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