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AB141282

Dienogest, Steroidal progesterone

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(1 Publication)

MW 311.4 Da, Purity >99%. Steroidal progesterone. Non-ethinylated progestin structurally related to testosterone. Anti-androgenic and antiproliferative effects in vitro.
2 Images
Functional Studies - Dienogest, Steroidal progesterone (AB141282)
  • FuncS

Unknown

Functional Studies - Dienogest, Steroidal progesterone (AB141282)

ab16895 staining MDM2 in MCF7 cells treated with dienogest (ab141282), by ICC/IF. Decrease in MDM2 expression correlates with increased concentration of dienogest, as described in literature.
The cells were incubated at 37°C for 24 hour in media containing different concentrations of ab141282 (dienogest) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab16895 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Chemical Structure - Dienogest, Steroidal progesterone (AB141282)
  • Chemical Structure

Lab

Chemical Structure - Dienogest, Steroidal progesterone (AB141282)

2D chemical structure image of ab141282, Dienogest, Steroidal progesterone

Key facts

CAS number

65928-58-7

Purity

>99%

Form

Solid

form

Molecular weight

311.4 Da

Molecular formula

C<sub>2</sub><sub>0</sub>H<sub>2</sub><sub>5</sub>NO<sub>2</sub>

PubChem

68861

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Dienogest

Biological description

Steroidal progesterone. Non-ethinylated progestin structurally related to testosterone. Anti-androgenic and antiproliferative effects in vitro.

Canonical smiles

CC12CCC3=C4CCC(=O)C=C4CCC3C1CCC2(CC#N)O

Isomeric smiles

C[C@]12CCC3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(CC#N)O

InChi

InChI=1S/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/m1/s1

InChiKey

AZFLJNIPTRTECV-FUMNGEBKSA-N

IUPAC Name

2-[(8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]acetonitrile

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Fertility and sterility 104:655-64.e1 PubMed26051103

2015

Dienogest enhances autophagy induction in endometriotic cells by impairing activation of AKT, ERK1/2, and mTOR.

Applications

Unspecified application

Species

Unspecified reactive species

JongYeob Choi,MinWha Jo,EunYoung Lee,Dong-Yun Lee,DooSeok Choi
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