JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB120260

Diltiazem, L-type Ca2+ channel antagonist

Be the first to review this product! Submit a review

|

(2 Publications)

MW 451 Da, Purity >99%. L-type Ca2+ channel antagonist. Coronary vasodilator. Soluble in 1 ml water to give specified mM/ml concentration.
1 Images
Chemical Structure - Diltiazem, L-type Ca2+ channel antagonist (AB120260)
  • Chemical Structure

Lab

Chemical Structure - Diltiazem, L-type Ca2+ channel antagonist (AB120260)

2D chemical structure image of ab120260, Diltiazem, L-type Ca2+ channel antagonist

Key facts

CAS number

33286-22-5

Purity

>99%

Form

Solid

form

Molecular weight

451 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>7</sub>ClN<sub>2</sub>O<sub>4</sub>S

PubChem

62920

Nature

Synthetic

Biochemical name

Diltiazem hydrochloride

Biological description

L-type Ca2+ channel antagonist. Coronary vasodilator. Soluble in 1 ml water to give specified mM/ml concentration.

Canonical smiles

CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

Isomeric smiles

CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

InChi

InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

InChiKey

HDRXZJPWHTXQRI-BHDTVMLSSA-N

IUPAC Name

[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride

style
left-column

Complementary Products

Biochemicals

AB120532

L-cis-Diltiazem, cyclic nucleotide-gated channel blocker

Chemical Structure - L-cis-Diltiazem, cyclic nucleotide-gated channel blocker (AB120532)

  • 0
  • 0
Biochemicals

AB120503

BAPTA-AM, Ca2+ chelator

Immunocytochemistry/ Immunofluorescence - BAPTA-AM, Ca2+ chelator (AB120503)

  • 0
  • 0
Biochemicals

AB141248

Docetaxel, Cytotoxic agent

Chemical Structure - Docetaxel, Cytotoxic agent (AB141248)

  • 0
  • 0
Biochemicals

AB120102

ZD7288, Sino-atrial node function modulator

Chemical Structure - ZD7288, Sino-atrial node function modulator (AB120102)

  • 0
  • 0
style
left-column
style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell communication and signaling : CCS 22:92 PubMed38303059

2024

T-type voltage-gated channels, Na/Ca-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Yan,Lan Wang,Qian-Lu Yang,Qian-Xi Yang,Xinyi He,Yujie Dong,Zhulin Hu,Mathias W Seeliger,Kangwei Jiao,François Paquet-Durand

Cell death & disease 13:47 PubMed35013127

2022

Redefining the role of Ca-permeable channels in photoreceptor degeneration using diltiazem.

Applications

Unspecified application

Species

Unspecified reactive species

Soumyaparna Das,Valerie Popp,Michael Power,Kathrin Groeneveld,Jie Yan,Christian Melle,Luke Rogerson,Marlly Achury,Frank Schwede,Torsten Strasser,Thomas Euler,François Paquet-Durand,Vasilica Nache
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com