Dinaciclib, cyclin-dependent kinase (CDK) inhibitor

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MW 396.5 Da, Purity >98%. Novel, potent, selective cyclin-dependent kinase (CDK) inhibitor displaying selectivity for CDK1, CDK2, CDK5 and CDK9 (IC₅₀ values are 3, 1, 1 and 4 nM respectively). Potent DNA replication inhibitor that blocks thymidine incorporation in A2780 ovarian cancer cells (IC₅₀ = 4 nM).

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39 kDa protein kinase, 6330408H09Rik, AI327039, AI661354, AV102684, AW538719, B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, BRD 6, BRD4-NUT FUSION, BRD4-NUT fusion oncoprotein, BRD4_HUMAN, BRDT protein, BRDT_HUMAN, Beta-interferon, Bromodomain containing 4, Bromodomain testis specific, Bromodomain testis-specific protein, Bromodomain-containing protein 4, C-2K, CAK, CAK 1, CAK complex subunit, CAP, CAP35, CCNA, CCNA2_HUMAN, CCNB, CCNB1_HUMAN, CCND1/FSTL3 fusion gene, CCND1/FSTL3 fusion gene, included, CCND1/IGHG1 fusion gene, CCND1/IGHG1 fusion gene, included, CCND1/IGLC1 fusion gene, CCND1/IGLC1 fusion gene, included, CCND1/PTH fusion gene, CCND1/PTH fusion gene, included, CCND1_HUMAN, CCNE, CCNE1_HUMAN, CCNH_HUMAN, CCNT, CCNT1_HUMAN, CD1, CD5R1_HUMAN, CDC28, CDC28A, CDC2A, CDC2L4, CDK activating kinase complex subunit, CDK-activating kinase, CDK-activating kinase 1, CDK-activating kinase assembly factor MAT1, CDK1_HUMAN, CDK2_HUMAN, CDK4 protein, CDK4_HUMAN, CDK5 activator 1, CDK5P35, CDK5R, CDK5R1, CDK5_HUMAN, CDK7/cyclin-H assembly factor, CDK7_HUMAN, CDK9 associated C type protein, CDK9_HUMAN, CDKN1, CDKN2, CDKN7, CELL CYCLE CONTROLLER CDC2, CMM 3, CT9, Cancer/testis antigen 9, Cdc 2, Cdc2-related kinase, Cell Divsion Cycle 2 Protein, Cell devision kinase 2, Cell division control protein 2, Cell division control protein 2 homolog, Cell division cycle 2 G1 to S and G2 to M, Cell division cycle 2-like protein kinase 4, Cell division kinase 4, Cell division protein kinase 1, Cell division protein kinase 2, Cell division protein kinase 4, Cell division protein kinase 5, Cell division protein kinase 7, Cell division protein kinase 9, Crk3, Crk6, Cyc T1, Cyclin B1, Cyclin C related protein, Cyclin E1, Cyclin Es, Cyclin Et, Cyclin T1b, Cyclin dependent kinase activating kinase, Cyclin-A, Cyclin-A2, Cyclin-G1-interacting protein, Cyclin-H, Cyclin-T, Cyclin-T1, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Cyclin-dependent kinase 5, Cyclin-dependent kinase 5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, Cyclin-dependent kinase 7, Cyclin-dependent kinase 9, CyclinE, Cyl 1, D11S287E, DKFZp686L20222, Fibroblast interferon, G1/S specific cyclin E, G1/S-specific cyclin-D1, G1/S-specific cyclin-E1, G2 mitotic specific cyclin B1, G2/mitotic-specific cyclin-B1, HCAK, HIVE1, HSF1_HUMAN, HSTF 1, HUNK1, HUNKI, Heat shock factor 1, Heat shock factor protein 1, Heat shock transcription factor 1, Homolog of Xenopus MO15 Cdk activating kinase, Human immunodeficiency virus 1 expression, Human immunodeficiency virus type 1 (HIV 1) expression (elevated) 1, IFB, IFF, IFN-beta, IFNB 1, IFNB_HUMAN, Interferon beta, Interferon beta 1 fibroblast, Interferon beta precursor, Kinase subunit of CAK, MAT1_HUMAN, MCAP, MGC111195, MGC14458, MGC96956, MNAT 1, MNAT CDK activating kinase assembly factor 1, MO15, MO15, Xenopus, homolog of, MO15-associated protein, MPF, Melanoma cutaneous malignant 3, Menage a trois, Menage a trois 1 (CAK assembly factor), Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis), Mitotic chromosome-associated protein, NCK 5A, Neuronal CDK5 activator, P23, P34CDC2, P35, P37, P39 Mo15, PITALRE, PRAD1, PRAD1 oncogene, PSK-J3, PSSALRE, Parathyroid adenomatosis 1, Protein HUNK1, Protein kinase CDK5 splicing, RING finger protein 66, RING finger protein MAT1, RING3-like protein, RNF66, Regulatory partner for CDK5 kinase, STK-1, Serine threonine kinase Stk1, Serine threonine protein kinase PSSALRE, Serine/threonine protein kinase 1, Serine/threonine protein kinase MO15, Serine/threonine-protein kinase PITALRE, Serine/threonine-protein kinase PSSALRE, Subunit of positive elongation transcription factor b, TAK, TFB3, TFIIH basal transcription factor complex kinase subunit, TPKII catalytic subunit, TPKII regulatory subunit, Tat associated kinase complex catalytic subunit, Tau protein kinase II 23 kDa subunit, Tau protein kinase II catalytic subunit, Testis specific bromodomain protein, U21B31, cdc2-related protein kinase, chromosome associated protein, cyclin E variant ex5del, cyclin E variant ex7del, cyclin dependent kinase 2-alpha, cyclin dependent kinase activating kinase complex subunit, cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase), kinase Cdc2, p25, p33 protein kinase, p33(CDK2), p34, p34 Cdk1, p34 cdk4, p34 protein kinase, p36, pTEFb subunit