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AB141274

Disuccinimidyl suberate, cross-linking reagent

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(5 Publications)

MW 368.34 Da, Purity >99%. Homobifunctional primary amine reactive cross-linker. Contains an 8 atom linker (11.4 Å) and can cross-link distances up to ~25 Å due to protein flexibility. Produces no toxic side products.
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Chemical Structure - Disuccinimidyl suberate, cross-linking reagent (AB141274)
  • Chemical Structure

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Chemical Structure - Disuccinimidyl suberate, cross-linking reagent (AB141274)

2D chemical structure image of ab141274, Disuccinimidyl suberate, cross-linking reagent

Key facts

CAS number

68528-80-3

Purity

>99%

Form

Solid

form

Molecular weight

368.34 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>0</sub>N<sub>2</sub>O<sub>8</sub>

PubChem

100658

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Disuccinimidyl suberate

Biological description

Homobifunctional primary amine reactive cross-linker. Contains an 8 atom linker (11.4 Å) and can cross-link distances up to ~25 Å due to protein flexibility. Produces no toxic side products.

Canonical smiles

C1CC(=O)N(C1=O)OC(=O)CCCCCCC(=O)ON2C(=O)CCC2=O

InChi

InChI=1S/C16H20N2O8/c19-11-7-8-12(20)17(11)25-15(23)5-3-1-2-4-6-16(24)26-18-13(21)9-10-14(18)22/h1-10H2

InChiKey

ZWIBGKZDAWNIFC-UHFFFAOYSA-N

IUPAC Name

bis(2,5-dioxopyrrolidin-1-yl) octanedioate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
The product can be stored for up to 12 months
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Product protocols

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Heliyon 10:e34591 PubMed39130485

2024

New compatible pair of TCM: Paeoniae Radix Alba effectively alleviate Psoraleae Fructus-induced liver injury by suppressing NLRP3 inflammasome activation.

Applications

Unspecified application

Species

Unspecified reactive species

Yingjie Xu,Xianling Wang,Yan Wang,Longxin Guo,Xiaomei Zhao,Ming Dong,Jincai Wen,Zhixin Wu,Chenyi Li,Wenqing Mu,Yuming Guo,Zhaofang Bai,Xiaohe Xiao

Cell communication and signaling : CCS 21:123 PubMed37231437

2023

Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation.

Applications

Unspecified application

Species

Unspecified reactive species

Wenqing Mu,Guang Xu,Zhilei Wang,Qiang Li,Siqiao Sun,Qin Qin,Zhiyong Li,Wei Shi,Wenzhang Dai,Xiaoyan Zhan,Jiabo Wang,Zhaofang Bai,Xiaohe Xiao

Cellular & molecular immunology 20:264-276 PubMed36600053

2023

The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection.

Applications

Unspecified application

Species

Unspecified reactive species

Fangrui Zhu,Dou Yu,Xiwen Qin,Yan Qian,Juan Ma,Weitao Li,Qiannv Liu,Chunlei Wang,Yan Zhang,Yi Li,Dong Jiang,Shuo Wang,Pengyan Xia

The EMBO journal 40:e108249 PubMed34296442

2021

SARS-CoV-2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Ma,Fangrui Zhu,Min Zhao,Fei Shao,Dou Yu,Jiangwen Ma,Xusheng Zhang,Weitao Li,Yan Qian,Yan Zhang,Dong Jiang,Shuo Wang,Pengyan Xia

JCI insight 6: PubMed33350984

2021

Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.

Applications

Unspecified application

Species

Unspecified reactive species

Guang Xu,Shubin Fu,Xiaoyan Zhan,Zhilei Wang,Ping Zhang,Wei Shi,Nan Qin,Yuanyuan Chen,Chunyu Wang,Ming Niu,Yuming Guo,Jiabo Wang,Zhaofang Bai,Xiaohe Xiao
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