D,L-Thioctic acid (DL-alpha-Lipoic acid), Non-specific free radical scavenger
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MW 206.3 Da, Purity >98%. Non-specific free radical scavenger. Prevents lipid peroxidation and promotes mitochondrial permeability transition in vitro. Anti-oxidant. Active in vivo and in vitro.
View Alternative Names
AOS1, Activator of SUMO1, Anthracycline-associated resistance ARX, BAZ2B_HUMAN, Bromodomain adjacent to zinc finger domain 2B, Bromodomain adjacent to zinc finger domain protein 2B, C358B7.1, DKFZp434H071, DKFZp762I0516, DNA directed DNA polymerase beta, DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit, DPOLB_HUMAN, FLJ13058, FLJ45644, HRIHFB2115, HSPC140, MGC125976, OTTHUMP00000162897, OTTHUMP00000162898, Pol B, Pol beta, Polymerase (DNA directed) beta, SAE1_HUMAN, SAE2_HUMAN, SUA1, SUMO 1 activating enzyme E1 N subunit, SUMO 1 activating enzyme subunit 1, SUMO 1 activating enzyme subunit 2, SUMO 1 protein ligase, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, SUMO-conjugating enzyme UBC9, SUMO-protein ligase, Sentrin/SUMO activating protein AOS1, UBA2, UBA2 ubiquitin activating enzyme E1 homolog, UBC9_HUMAN, UBCE9, UBL E1A, UBLE1B, Ube2i, Ubiquitin carrier protein, Ubiquitin carrier protein 9, Ubiquitin carrier protein I, Ubiquitin conjugating enzyme 9, Ubiquitin conjugating enzyme E2I (UBC9 homolog, yeast), Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9), Ubiquitin conjugating enzyme UbcE2A, Ubiquitin like modifier activating enzyme 2, Ubiquitin like protein SUMO 1 conjugating enzyme, Ubiquitin like protein SUMO1 activating enzyme, Ubiquitin protein ligase E2I, Ubiquitin-conjugating enzyme E2 I, Ubiquitin-like 1-activating enzyme E1A, Ubiquitin-like 1-activating enzyme E1B, Ubiquitin-protein ligase I, WALp4, hWALp4, p18
- Chemical Structure
Lab
Chemical Structure - D,L-Thioctic acid (DL-alpha-Lipoic acid), Non-specific free radical scavenger (AB142952)
2D chemical structure image of ab142952, D,L-Thioctic acid (DL-alpha-Lipoic acid), Non-specific free radical scavenger
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
DNA Polymerase beta conducts gap-filling DNA synthesis and is the focal enzyme in the BER pathway responsible for repairing single-strand DNA breaks. It does not form part of a large complex but works in concert with other single proteins involved in BER. UBE2I/UBC9 works closely with SAE1 and SAE2/UBA2 to mediate the transfer of SUMO proteins in the sumoylation process. This modification impacts a range of cellular processes including transcriptional regulation DNA repair and signal transduction. BAZ2B plays a role in modulating the accessibility of chromatin and can impact gene expression.
Pathways
These proteins are integral to maintaining genomic stability and regulating protein function. DNA Polymerase beta plays a central role in the BER pathway alongside other repair proteins like XRCC1 and APE1. It ensures the integrity of genetic information is preserved after DNA damage. UBE2I linked to the sumoylation pathway modulates the function of many key proteins by adding SUMO tags thereby linking it to proteins like p53 which are important for regulating cell cycle and apoptosis. BAZ2B interacts with chromatin remodelers to facilitate transcriptional regulation impacting gene expression.
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