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AB144023

D,L-threo-PPMP, Glucosylceramide synthase inhibitor

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MW 474.7 Da, Purity >98%. Endogenous glucosylceramide synthase inhibitor. Ceramide (ab141743, ab141745) structural analog. Blocks karyokinesis and reduces cyst production. Inhibits glucosylceramide synthesis.
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Chemical Structure - D,L-threo-PPMP, Glucosylceramide synthase inhibitor (AB144023)
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Chemical Structure - D,L-threo-PPMP, Glucosylceramide synthase inhibitor (AB144023)

2D chemical structure image of ab144023, D,L-threo-PPMP, Glucosylceramide synthase inhibitor

Key facts

CAS number

149022-18-4

Purity

>98%

Molecular weight

474.7 Da

Molecular formula

C<sub>2</sub><sub>9</sub>H<sub>5</sub><sub>0</sub>N<sub>2</sub>O<sub>3</sub>

PubChem

3008318

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Biochemical name

(1R,2R)-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol

Biological description

Endogenous glucosylceramide synthase inhibitor. Ceramide (ab141743, ab141745) structural analog. Blocks karyokinesis and reduces cyst production. Inhibits glucosylceramide synthesis.

Canonical smiles

CCCCCCCCCCCCCCCC(=O)NC(CN1CCOCC1)C(C2=CC=CC=C2)O

Isomeric smiles

CCCCCCCCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@@H](C2=CC=CC=C2)O

InChi

InChI=1S/C29H50N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-28(32)30-27(25-31-21-23-34-24-22-31)29(33)26-18-15-14-16-19-26/h14-16,18-19,27,29,33H,2-13,17,20-25H2,1H3,(H,30,32)/t27-,29-/m1/s1

InChiKey

OFBANDBMHLEMFA-XRKRLSELSA-N

IUPAC Name

N-[(1R,2R)-1-hydroxy-3-morpholin-4-yl-1-phenylpropan-2-yl]hexadecanamide

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Biochemicals

AB143963

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Chemical Structure - 1-Palmitoyl-sn-glycero-3-phosphorylcholine (AB143963)

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Biochemicals

AB142100

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Primary Antibodies

AB133514

Anti-NEK7 antibody [EPR4900]

RabMAb|Recombinant|KO Validated|Trial Size

Immunoprecipitation - Anti-NEK7 antibody [EPR4900] (AB133514)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Product promise

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