MW 293.41 g/mol. NF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC50 = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active.
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Publications
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- Iranian journal of basic medical sciences 24:1421-14272022Dimethylaminoparthenolide (DMAPT) as an alternative approach for treatment of Familial Mediterranean Fever (FMF).Applications:Unspecified applicationReactive species:Unspecified reactive speciesAli Mosayebian,Roya Sherkat,Saied Abediankenari,Monireh Golpour,Alireza RafieiPubMed 35096301
Key facts
- CAS number
- 870677-05-7
- Form
- Solid
- Molecular weight
- 293.41 g/mol
- Molecular formula
- C17H27NO3
- Nature
- Synthetic
Recommended products
MW 293.41 g/mol. NF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC50 = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active.
Key facts
- CAS number
- 870677-05-7
- Form
- Solid
- Molecular weight
- 293.41 g/mol
- Molecular formula
- C17H27NO3
- Nature
- Synthetic
- Biological description
NF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC50 = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active.
- IUPAC name
- (1aR,4E,7aS,8R,10aS,10bS)-8-[(Dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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1 product image
Chemical Structure - DMAPT, NF-kappaB inhibitor (ab146189)
2D chemical structure image of ab146189, DMAPT, NF-kappaB inhibitor
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