DMAPT, NF-kappaB inhibitor

Key facts

CAS number

870677-05-7

Form

Solid

form

Molecular weight

293.41 g/mol

Molecular formula

C₁₇H₂₇NO₃

Nature

Synthetic

Biological description

NF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC₅₀ = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active.

IUPAC Name

(1aR,4E,7aS,8R,10aS,10bS)-8-[(Dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one