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AB144610

DMPO, hydrophilic spin trap

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(1 Publication)

MW 113.16 Da, Purity >99%. Cell-permeable hydrophilic spin trap. React with radicals forming stable adducts. Reacts with O-, N-, S-, and C-centred radicals. Reduces NMDA-induced neuronal death in vitro. Reduces nickel-induced DNA damage in vitro. Antioxidant and neuroprotective agent. Active in vivo and in vitro.
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Chemical Structure - DMPO, hydrophilic spin trap (AB144610)
  • Chemical Structure

Lab

Chemical Structure - DMPO, hydrophilic spin trap (AB144610)

2D chemical structure image of ab144610, DMPO, hydrophilic spin trap

Key facts

CAS number

3317-61-1

Purity

>99%

Molecular weight

113.16 Da

Molecular formula

C<sub>6</sub>H<sub>1</sub><sub>1</sub>NO

PubChem

1774

Nature

Synthetic

Solubility

Soluble in DMSO to 10 mM

Soluble in ethanol to 10 mM

Biochemical name

5,5-Dimethyl-1-pyrroline N-oxide

Biological description

Cell-permeable hydrophilic spin trap. React with radicals forming stable adducts. Reacts with O-, N-, S-, and C-centred radicals. Reduces NMDA-induced neuronal death in vitro. Reduces nickel-induced DNA damage in vitro. Antioxidant and neuroprotective agent. Active in vivo and in vitro.

Canonical smiles

CC1(CCC=[N+]1[O-])C

InChi

InChI=1S/C6H11NO/c1-6(2)4-3-5-7(6)8/h5H,3-4H2,1-2H3

InChiKey

VCUVETGKTILCLC-UHFFFAOYSA-N

IUPAC Name

2,2-dimethyl-1-oxido-3,4-dihydropyrrol-1-ium

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
It is important to note that this product is reported to be light sensitive|Store in the dark|Store under desiccating conditions
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Redox biology 63:102733 PubMed37172395

2023

Temporary alteration of neuronal network communication is a protective response to redox imbalance that requires GPI-anchored prion protein.

Applications

Unspecified application

Species

Unspecified reactive species

Simote T Foliaki,Aleksandar Wood,Katie Williams,Anna Smith,Ryan O Walters,Chase Baune,Bradley R Groveman,Cathryn L Haigh
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