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AB120169

DNQX disodium salt, AMPA / kainate antagonist

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(16 Publications)

MW 296.1 Da, Purity >99%. Water soluble AMPA / kainate antagonist. Achieve your results faster with highly validated, pure and trusted compounds.

View Alternative Names

AMPA 1, AMPA-selective glutamate receptor 1, GLUH1, GRIA1_HUMAN, GluA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 1, HBGR1, MGC133252, OTTHUMP00000160643, OTTHUMP00000165781, OTTHUMP00000224241, OTTHUMP00000224242, OTTHUMP00000224243

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Functional Studies - DNQX disodium salt, AMPA / kainate antagonist (AB120169)
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Functional Studies - DNQX disodium salt, AMPA / kainate antagonist (AB120169)

ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with DNQX disodium salt (ab120169), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of DNQX disodium salt, as described in literature.
The cells were incubated at 37°C for 3h in media containing different concentrations of ab120169 (DNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight® 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

Chemical Structure - DNQX disodium salt, AMPA / kainate antagonist (AB120169)
  • Chemical Structure

Lab

Chemical Structure - DNQX disodium salt, AMPA / kainate antagonist (AB120169)

2D chemical structure image of ab120169, DNQX disodium salt, AMPA / kainate antagonist

Key facts

CAS number

1312992-24-7

Purity

>99%

Form

Solid

form

Molecular weight

296.1 Da

Molecular formula

C<sub>8</sub>H<sub>2</sub>N<sub>4</sub>Na<sub>2</sub>O<sub>6</sub>

PubChem

45073428

Nature

Synthetic

Biochemical name

Dnqx disodium salt

Biological description

Water soluble AMPA / kainate antagonist.

Canonical smiles

C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])N=C(C(=N2)[O-])[O-].[Na+].[Na+]

InChi

InChI=1S/C8H4N4O6.2Na/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7;;/h1-2H,(H,9,13)(H,10,14);;/q;2*+1/p-2

InChiKey

GPSBSOYURFUVKJ-UHFFFAOYSA-L

IUPAC Name

disodium;6,7-dinitroquinoxaline-2,3-diolate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Glutamate Receptor 1 (AMPA subtype) also known as GluR1 is a subunit of the AMPA receptor complex which mediates fast synaptic transmission in the central nervous system. It is an ionotropic receptor for glutamate functioning by opening ion channels to allow the flow of Na+ and Ca2+ ions across the cell membrane contributing to excitatory neurotransmission. The GluR1 subunit has a molecular mass of approximately 100 kDa. This receptor is commonly expressed in the brain regions such as the hippocampus and the cerebral cortex playing an important role in synaptic plasticity and memory formation.
Biological function summary

The GluR1 subunit is an essential component of the AMPA receptor complex which typically forms as a tetramer. This complex modulates synaptic strength and plasticity processes critical for learning and memory. The activity of AMPA receptors including those containing GluR1 is regulated by several auxiliary proteins and is essential for post-synaptic responses. The GluR1 subunit also interacts with other proteins such as TARPs which modulate its trafficking and channel properties.

Pathways

The GluR1-containing AMPA receptors participate significantly in the glutamatergic signaling pathway which is vital for fast excitatory synaptic transmission in the brain. This pathway also involves the NMDA receptors which work together with AMPA receptors to regulate synaptic plasticity and neuronal communication. Additionally the GluR1 interacts within the long-term potentiation (LTP) pathway contributing to the strengthening of synapses an essential mechanism underlying learning and memory.

Dysfunction in GluR1 and associated AMPA receptors has been implicated in conditions like Alzheimer's disease and epilepsy. Alzheimer's disease exhibits decreased synaptic transmission and plasticity linked to impaired GluR1 function and its interactions with NMDA receptors. In epilepsy abnormal GluR1 activity may contribute to heightened neuronal excitability and seizure propagation. Targeting GluR1 or associated pathways offers potential for therapeutic interventions in these disorders possibly through drugs such as memantine and NBQX which modulate receptor activity.
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Product protocols

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Publications (16)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed39531384

2024

A non-conducting role of the Ca1.4 Ca channel drives homeostatic plasticity at the cone photoreceptor synapse.

Applications

Unspecified application

Species

Unspecified reactive species

J Wesley Maddox,Gregory J Ordemann,Juan A M de la Rosa Vázquez,Angie Huang,Christof Gault,Serena R Wisner,Kate Randall,Daiki Futagi,Nihal A Salem,Dayne Mayfield,Boris V Zemelman,Steven DeVries,Mrinalini Hoon,Amy Lee

Nature communications 14:3886 PubMed37391566

2023

Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Himanshu Gangal,Xueyi Xie,Zhenbo Huang,Yifeng Cheng,Xuehua Wang,Jiayi Lu,Xiaowen Zhuang,Amanda Essoh,Yufei Huang,Ruifeng Chen,Laura N Smith,Rachel J Smith,Jun Wang

Communications biology 6:267 PubMed36918719

2023

Mir125b-2 imprinted in human but not mouse brain regulates hippocampal function and circuit in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ming-Yi Chou,Xuhui Cao,Kuan-Chu Hou,Meng-Han Tsai,Chih-Yu Lee,Meng-Fai Kuo,Vin-Cent Wu,Hsin-Yi Huang,Schahram Akbarian,Sheng-Kai Chang,Chung-Yi Hu,Shu-Wha Lin,Hsien-Sung Huang

Cell reports 40:111380 PubMed36130511

2022

An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow.

Applications

Unspecified application

Species

Unspecified reactive species

Akihiro Fukushima,Naoya Kataoka,Kazuhiro Nakamura

Cell reports 28:2427-2442.e6 PubMed31461656

2019

Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Giriraj Sahu,Rima-Marie Wazen,Pina Colarusso,S R Wayne Chen,Gerald W Zamponi,Ray W Turner

Cell reports 28:992-1002.e4 PubMed31340159

2019

Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Eileen L McIver,Jeremy F Atherton,Hong-Yuan Chu,Kathleen E Cosgrove,Jyothisri Kondapalli,David Wokosin,D James Surmeier,Mark D Bevan

eLife 8: PubMed31090538

2019

Elevated synaptic vesicle release probability in synaptophysin/gyrin family quadruple knockouts.

Applications

Unspecified application

Species

Unspecified reactive species

Mathan K Raja,Julia Preobraschenski,Sergio Del Olmo-Cabrera,Rebeca Martinez-Turrillas,Reinhard Jahn,Isabel Perez-Otano,John F Wesseling

Molecular cell 71:956-972.e9 PubMed30146317

2018

The Evf2 Ultraconserved Enhancer lncRNA Functionally and Spatially Organizes Megabase Distant Genes in the Developing Forebrain.

Applications

Unspecified application

Species

Unspecified reactive species

Ivelisse Cajigas,Abhijit Chakraborty,Kelsey R Swyter,Hao Luo,Monique Bastidas,Maximilliano Nigro,Elizabeth R Morris,Sean Chen,Michael J W VanGompel,David Leib,Sara J Kohtz,Marco Martina,Sooky Koh,Ferhat Ay,Jhumku D Kohtz

Neuron 95:1306-1318.e5 PubMed28910619

2017

Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Hong-Yuan Chu,Eileen L McIver,Ryan F Kovaleski,Jeremy F Atherton,Mark D Bevan

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:9369-80 PubMed26109660

2015

Enhanced GABAA-Mediated Tonic Inhibition in Auditory Thalamus of Rats with Behavioral Evidence of Tinnitus.

Applications

Unspecified application

Species

Unspecified reactive species

Evgeny A Sametsky,Jeremy G Turner,Deb Larsen,Lynne Ling,Donald M Caspary
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