Docetaxel, Cytotoxic agent

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(4 Publications)

MW 807.9 Da, Purity >99%. Potent cytotoxic agent in vitro (IC₅₀ = 2 nM). Disrupts microtubule assembly and arrests cell divison at G₂/M phase. Induces apoptosis. Antitumor agent. Active in vivo and in vitro.

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ABC member 16, MDR/TAP subfamily, ABC16, ABCB1, ABCBB_HUMAN, ACUG, AI838772, AIS, ANDR_HUMAN, AR, AR8, ATP binding cassette sub family B (MDR/TAP) member 11, ATP-binding cassette sub-family B member 11, AW493413, Androgen nuclear receptor variant 2, Androgen receptor, Androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease), Antigen NY-CO-13, Arthrocutaneouveal granulomatosis, Atherosclerosis, susceptibility to, included, BCC7, BLAU, BRIC2, Bile salt export pump, Bsep, CAR, CAR BETA, CARA, CARD15, CD, CLR16.3, Car 1, Caspase recruitment domain family, member 15, Caspase recruitment domain protein 15, Caspase recruitment domain-containing protein 15, Cellular tumor antigen p53, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, DHTR, DKFZp686N23123, Dihydro testosterone receptor, Dihydrotestosterone receptor (DHTR), ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, FLJ11090, FLJ92943, GCCR, GCRST, GCR_HUMAN, GR, Glucocorticoid receptor, Grl1, HDL cholesterol, augmented response of, to hormone replacement, included, HUMARA, HYSP1, IBD1, Inflammatory bowel disease protein 1, KD, Kennedy disease (KD), LFS1, LRR containing protein, MB67, MGC104252, MGC112732, MGC97144, Mutant tumor protein 53, Myocardial infarction, susceptibility to, included, NLR family, CARD domain containing 2, NLRC2, NOD like receptor C2, NOD2 protein, NOD2B, NOD2_HUMAN, NR1B1, NR1I3_HUMAN, NR3A1, NR3A2, NR3B1, NR3C4, Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein, Nuclear receptor subfamily 1 group B member 1, Nuclear receptor subfamily 1 group I member 3, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 4, Nuclear receptor subfamily 3 group C member 4 (NR3C4), Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form, Nucleotide binding oligomerization domain containing 2, Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2, Nucleotide-binding oligomerization domain-containing protein 2, OTTHUMP00000017718, OTTHUMP00000017719, Orphan nuclear receptor MB67, Orphan nuclear receptor NR1I3, P53_HUMAN, PFIC 2, PGY4, PSORAS1, Phosphoprotein p53, RAR, RAR-alpha, RARA_HUMAN, RARalpha1, RNESTROR, RP24-311F12.2, Retinoic acid nuclear receptor alpha variant 1, Retinoic acid nuclear receptor alpha variant 2, Retinoic acid receptor alpha, Retinoic acid receptor alpha polypeptide, SBMA, SCAN1, SMAX1, Sister of P glycoprotein, Spgp, Spinal and bulbar muscular atrophy, Spinal and bulbar muscular atrophy (SBMA), Steroid hormone receptor ERR1, TFM, TRP53, TYDP, TYDP1_HUMAN, Testicular Feminization (TFM), Tp53, Transformation related protein 53, Tumor protein 53, Tumor protein p53, Tumor suppressor p53, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, androgen receptor splice variant 4b, constitutive active receptor, constitutive androstane nuclear receptor variant 2, constitutive androstane nuclear receptor variant 3, constitutive androstane nuclear receptor variant 4, constitutive androstane nuclear receptor variant 5, estrogen receptor related receptor alpha, glucocorticoid nuclear receptor variant 1, hERR1, nr3c1, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), nucleotide binding oligomerization domain 2, orphan nuclear hormone receptor, p53 tumor suppressor, progressive familial intrahepatic cholestasis 2, tumor antigen p55