Dolutegravir, HIV integrase inhibitor

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MW 419.4 Da. Potent HIV integrase inhibitor (IC₅₀ = 2.7 nM for HIV-1 integrase-catalyzed strand transfer in vitro). Inhibits HIV-1 viral replication (EC₅₀ = 0.51 nM) in peripheral blood mononuclear cells (PBMCs). Prevents replication of several HIV-1 strains (EC₅₀ values of 0.36-2.1 nM) that are resistant to nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs), and protease inhibitors.

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1,8-cineole 2-exo-monooxygenase, AChR, AL024364, Aging-associated gene 8 protein, Albendazole monooxygenase, Albendazole sulfoxidase, BILIQTL1, Bilirubin-specific UDPGT isozyme 1, CP33, CP34, CP3A4_HUMAN, CYP3, CYP3A, CYP3A3, CYP3A4, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 3A4, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450 family 3 subfamily A polypeptide 4, Cytochrome P450 subfamily IIIA polypeptide 4, Cytochrome P450-PCN1, EC 2.4.1.17, GNT1, Glucocorticoid inducible P450, HLP, HUG-BR1, MGC126680, MGC12716, NF 25, Nifedipine oxidase, P450 III steroid inducible, P450 PCN1, P450, family III, P450C3, PHENOL/BILIRUBIN UDP GLUCURONOSYLTRANSFERASE, Quinine 3-monooxygenase, RP23 167I12.6, SGMR1_HUMAN, SIG-1R, SR-BP, SR31747-binding protein, Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1, Sigma1-receptor, Sigma1R, Sigmar1, Slc18a3, Solute carrier family 18 (vesicular acetylcholine) member 3, Solute carrier family 18 (vesicular monoamine) member 3, Solute carrier family 18 member 3, Taurochenodeoxycholate 6-alpha-hydroxylase, UD11_HUMAN, UDP GLYCOSYLTRANSFERASE 1, UDP glucuronosyltransferase 1 1 [Precursor], UDP glucuronosyltransferase 1 family polypeptide A1, UDP-glucuronosyltransferase 1-1, UDP-glucuronosyltransferase 1-A, UDP-glucuronosyltransferase 1A1, UDPGT, UDPGT 1-1, UGT-1A, UGT1, UGT1*1, UGT1-01, UGT1.1, URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASE, BILIRUBIN/PHENOL, URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1, URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A1, VACHT_HUMAN, Vesicular acetylcholine transporter, bilirubin UDP glucuronosyltransferase 1 1, bilirubin UDP glucuronosyltransferase isozyme 1, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4, hSigmaR1, mSigmaR1, opioid receptor, sigma 1, opioid receptor, sigma 1 isoform 1, rVAT