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AB120566

Domperidone, Peripheral D2-like receptor antagonist

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(1 Publication)

MW 425.9 Da, Purity >99%. Peripheral D2-like receptor antagonist. Does not readily cross the blood-brain barrier, and displays gastrokinetic and antiemetic properties.

View Alternative Names

3dopamine receptor, 5 HT 2B receptor, 5 HT(2B), 5 HT2 receptor, 5 HTT, 5 HTTLPR, 5 Hydroxytryptamine 2C receptor, 5 hydroxytryptamine (serotonin) receptor 2B, 5 hydroxytryptamine (serotonin) receptor 2B G protein coupled, 5 hydroxytryptamine (serotonin) transporter, 5 hydroxytryptamine 2B receptor, 5 hydroxytryptamine transporter, 5-HT-1C, 5-HT-2, 5-HTR2C, 5-ht-1c receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine receptor 1C, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 2C, 5HT transporter, 5HT2A_HUMAN, 5HT2B_HUMAN, 5HT2C_HUMAN, 5HT2F, ACLS, ADA1D_HUMAN, ADA2A_HUMAN, ADRA1A, ADRA1L1, ADRA2, ADRA2A, ADRA2R, ADRAR, AI838772, AP-1, ATAD5_HUMAN, ATPase family AAA domain containing 5, ATPase family AAA domain-containing protein 5, AW493413, Activator protein 1, Adra1d, Adrenergic alpha 1A receptor, Adrenergic alpha 1B receptor, Adrenergic alpha 1C receptor, Adrenergic alpha 1D receptor, Adrenergic alpha 2A receptor, Alpha 2AAR subtype C10, Alpha adrenergic receptor 1b, Alpha adrenergic receptor 1d, Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor, Alpha-1D adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-2 adrenergic receptor subtype C10, Alpha-2A adrenergic receptor, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, Alpha-adrenergic receptor 1a, Alpha-adrenergic receptor 1c, Atherosclerosis, susceptibility to, included, BPHS, mouse, homolog of, BXR, C17orf41, Chromosome fragility-associated gene 1 protein, D(2) dopamine receptor, D(3) dopamine receptor, D2 dopamine receptor, D2DR, D2R, DKFZp686N23123, DNA binding protein, DRD2_HUMAN, DRD3_HUMAN, Dopamine D2 receptor, Dopamine D3 receptor, Dopamine receptor D2, Dopamine receptor D3, ELG1, ER, ER-alpha, ER-beta, ERR a, ERR-alpha, ERR1 protein, ERR1_HUMAN, ER[a], ER[b], ESR, ESR B, ESR BETA, ESR1_HUMAN, ESRA, ESRL 1, ESRR A, ESTR B, ETM1, Eag-related protein 1, Enhanced level of genomic instability 1 homolog, Enhancer Binding Protein AP1, Era, Erb, Erb2, Estr, Estra, Estradiol Receptor alpha, Estradiol Receptor beta, Estradiol receptor, Estrogen Receptor 1, Estrogen Receptor 2, Estrogen receptor, Estrogen receptor 1 (alpha), Estrogen receptor 2 (ER beta), Estrogen receptor 2 ER beta, Estrogen receptor alpha, Estrogen receptor beta 4, Estrogen receptor related 1, Estrogen receptor-like 1, Estrogen resistance, included, Estrogen-related receptor alpha, Estrra, Ether a go go related potassium channel protein, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, FET1, FLJ00280, FLJ00318, FLJ10847, FLJ11090, FLJ16020, FLJ16733, FRAG1, GCPS, GLI Kruppel family member GLI 3, GLI Kruppel family member GLI3 (Greig cephalopolysyndactyly syndrome), GLI family zinc finger 3, GLI3 C-terminally truncated form, GLI3 form of 190 kDa, GLI3 form of 83 kDa, GLI3 full length protein, GLI3-190, GLI3-83, GLI3FL, GLI3_HUMAN, Glioma associated oncogene family zinc finger 3, H(+)/organic cation antiporter kidney-specific, H+/organic cation antiporter, H-ERG, H1 R, HDL cholesterol, augmented response of, to hormone replacement, included, HH1R, HRH1_HUMAN, HTR 2, HTR 2A, HTR2, formerly, HTR2C, HisH1, Histamine H(1) receptor, Histamine H1 receptor, Histamine receptor H1, Histamine receptor subclass H1, Htr 2b, Htr1c, JUN protein, JUNC, JUN_HUMAN, Jun Activation Domain Binding Protein, Jun oncogene, Jun proto oncogene, K-OR-1, KCNH2_HUMAN, Kappa opioid receptor, Kappa-type opioid receptor, Kidney-specific H(+)/organic cation antiporter, Kv11.1, LMOR, LQT 2, M-OR-1, MATE-1, MATE-2, MATE2 B, MATE2 K, MGC102720, MGC104252, MGC112732, MGC6482, MOR, Mu opiate receptor, Mu opioid receptor, Mu-type opioid receptor, Multidrug and toxin extrusion 2, Multidrug and toxin extrusion protein 1, Multidrug and toxin extrusion protein 2, Myocardial infarction, susceptibility to, included, NP75 protein, NR1I2_HUMAN, NR2B1, NR3A1, NR3A2, NR3B1, Na+/Cl- dependent serotonin transporter, Neurotransmitter transporter, Norepinephrine transporter, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor subfamily 2 group B member 1, Nuclear receptor subfamily 3 group A member 1, Nuclear receptor subfamily 3 group A member 2, Nuclear receptor subfamily 3 group B member 1, OCD1, ONR 1, OPRK 1, OPRK_HUMAN, OPRM1, OPRM_HUMAN, OTTHUMP00000017718, OTTHUMP00000017719, OTTHUMP00000022510, OTTHUMP00000058849, OTTHUMP00000215173, OTTHUMP00000215174, OTTHUMP00000215175, Oncogene GLI3, Oncogene JUN, Opiate receptor kappa 1, Opioid receptor mu 1, Opioid receptor, kappa 1, Oprk2, Orphan nuclear receptor PAR 1, Orphan nuclear receptor PXR, PAP A, PAPB, PAR, PAR q, PPD IV, PRR, Potassium channel HERG, Potassium voltage gated channel subfamily H (eag related) member 2, Potassium voltage-gated channel subfamily H member 2, Pregnane X receptor, Proto-oncogene c-jun, R21, RNESTROR, RP24-311F12.2, RXR alpha1, RXRA_HUMAN, Retinoic acid receptor RXR-alpha, Retinoid X nuclear receptor alpha, Retinoid X receptor alpha, S47A1_HUMAN, S47A2_HUMAN, SC6A2_HUMAN, SC6A4_HUMAN, SCAN1, SEROTONIN 5HT2B RECEPTOR, SERT, SERT1, SLC47A1, SLC47A2, SLC6A5, SQT1, SXR, Serotonin 5-HT-2C receptor, Serotonin receptor 2A, Serotonin receptor 2B, Serotonin receptor 2C, Serotonin transporter 1, Slc6a2, Slc6a4, Sodium-dependent noradrenaline transporter, Sodium-dependent serotonin transporter, Solute carrier family 47 member 1, Solute carrier family 47 member 2, Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5, Solute carrier family 6 (neurotransmitter transporter) member 4, Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, Solute carrier family 6 member 4, Solute carrier family 6 member 5, Steroid and xenobiotic receptor, Steroid hormone receptor ERR1, Stomach fundus serotonin receptor, TYDP, TYDP1_HUMAN, Transcription factor AP-1, Transcriptional activator GLI3, Transcriptional repressor GLI3R, Tyr-DNA phosphodiesterase 1, Tyrosyl-DNA phosphodiesterase 1, V jun sarcoma virus 17 oncogene homolog, V jun sarcoma virus 17 oncogene homolog (avian), V-jun avian sarcoma virus 17 oncogene homolog, Voltage gated potassium channel, subfamily H, member 2, Voltage-gated potassium channel subunit Kv11.1, Zinc finger protein GLI 3, alpha-2-adrenergic receptor, platelet type, cJun, chromosome fragility associated gene 1, eag homolog, estrogen receptor related receptor alpha, hERG-1, hERR1, hMATE-1, hMATE-2, hMOP, hSERT, multidrug and toxin extrusion 1, p39, pregnane X nuclear receptor variant 2, serotonin 1c receptor, serotonin 2c receptor, serotonin 5-HT-2 receptor, formerly, serotonin 5-HT-2A receptor, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

1 Images
Chemical Structure - Domperidone, Peripheral D2-like receptor antagonist (AB120566)
  • Chemical Structure

Lab

Chemical Structure - Domperidone, Peripheral D2-like receptor antagonist (AB120566)

2D chemical structure image of ab120566, Domperidone, Peripheral D2-like receptor antagonist

Key facts

CAS number

57808-66-9

Purity

>99%

Form

Solid

form

Molecular weight

425.9 Da

Molecular formula

C<sub>2</sub><sub>2</sub>H<sub>2</sub><sub>4</sub>ClN<sub>5</sub>O<sub>2</sub>

PubChem

3151

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Biochemical name

Domperidone

Biological description

Peripheral D2-like receptor antagonist. Does not readily cross the blood-brain barrier, and displays gastrokinetic and antiemetic properties.

Canonical smiles

C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O

InChi

InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChiKey

FGXWKSZFVQUSTL-UHFFFAOYSA-N

IUPAC Name

6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

C-Jun is a protein that functions as a transcription factor and is a part of the Activator Protein 1 (AP-1) complex. It is also known as Jun proto-oncogene. This protein is involved in regulating gene expression related to cell proliferation differentiation and apoptosis. The molecular mass of c-Jun is about 39 kDa. It is widely expressed in various tissues particularly found in the brain liver and spleen where it influences cellular responses to growth signals and stress.
Biological function summary

C-Jun plays an important role in cell cycle control and stress response mechanisms. It dimerizes with other proteins like c-Fos to form the AP-1 complex which binds to DNA and regulates transcription. This protein is involved in various cellular processes including neuronal activity and immune response influencing the expression of genes involved in cellular survival and death. c-Jun activation is typically mediated through signaling cascades such as the MAPK pathway.

Pathways

C-Jun is central to signaling pathways like JNK and ERK which are important for transmitting signals from membrane receptors to the cell nucleus. It interacts with proteins such as c-Fos and various kinases involved in these pathways to mediate cellular responses to extracellular stimuli. Within these signaling cascades c-Jun plays a pivotal role in translating external signals into specific gene expression patterns which are imperative for cellular adaptation and response.

C-Jun is associated with a variety of pathological conditions including cancer and neurodegenerative diseases. Overexpression or dysregulation of c-Jun has been implicated in the development of tumors as it may lead to abnormal cell proliferation. In neurodegenerative disorders such as Alzheimer's disease altered c-Jun activity can contribute to neuronal dysfunction and apoptosis. Researchers study its interactions with proteins like TDP1 and other AP-1 components to better understand its role in these diseases.

Product protocols

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:4424-33 PubMed23467359

2013

Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release.

Applications

Unspecified application

Species

Unspecified reactive species

Nicola Romanò,Siew H Yip,David J Hodson,Anne Guillou,Sébastien Parnaudeau,Siobhan Kirk,François Tronche,Xavier Bonnefont,Paul Le Tissier,Stephen J Bunn,Dave R Grattan,Patrice Mollard,Agnès O Martin
View all publications

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