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AB120763

Donepezil hydrochloride, Acetylcholinesterase inhibitor

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(1 Publication)

MW 415.96 g/mol, Purity >99%. Potent, selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo.
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Chemical Structure - Donepezil hydrochloride, Acetylcholinesterase inhibitor (AB120763)
  • Chemical Structure

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Chemical Structure - Donepezil hydrochloride, Acetylcholinesterase inhibitor (AB120763)

2D chemical structure image of ab120763, Donepezil hydrochloride, Acetylcholinesterase inhibitor

Key facts

CAS number

120011-70-3

Purity

>99%

Form

Solid

form

Molecular weight

415.96 g/mol

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>9</sub>NO<sub>3</sub>.HCl

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biological description

Potent, selective acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays >1250 times selectivity for AChE over butyrylcholinesterase. Centrally active. Neuroprotective activity in vitro and in vivo.

IUPAC Name

2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of nanomedicine 19:307-326 PubMed38229703

2024

A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate.

Applications

Unspecified application

Species

Unspecified reactive species

Kathleen F Pirollo,Manish Moghe,Miaoyin Guan,Antonina S Rait,Aibing Wang,Sang-Soo Kim,Esther H Chang,Joe B Harford
View all publications

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