MW 189.64 g/mol, Purity >99%. Endogenous neurotransmitter. Dopamine D1-5 receptor agonist. Norepinephrine and epinephrine precursor. Involved in numerous neurological functions and also in various conditions such as Parkinson's disease and schizophrenia.
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- Scientific reports 10:202032020Dopamine receptor D1- and D2-agonists do not spark brown adipose tissue thermogenesis in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrancesca-Maria Raffaelli et. al.PubMed 33214601
Key facts
- CAS number
- 62-31-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 189.64 g/mol
- Molecular formula
- C8H11NO2.HCl
- Nature
- Synthetic
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MW 189.64 g/mol, Purity >99%. Endogenous neurotransmitter. Dopamine D1-5 receptor agonist. Norepinephrine and epinephrine precursor. Involved in numerous neurological functions and also in various conditions such as Parkinson's disease and schizophrenia.
Key facts
- CAS number
- 62-31-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 189.64 g/mol
- Molecular formula
- C8H11NO2.HCl
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
- Biological description
Endogenous neurotransmitter. Dopamine D1-5 receptor agonist. Norepinephrine and epinephrine precursor. Involved in numerous neurological functions and also in various conditions such as Parkinson's disease and schizophrenia.
- IUPAC name
- 3,4-Dihydroxyphenethylamine hydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
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2 product images
Chemical Structure - Dopamine hydrochloride, Endogenous neurotransmitter (ab120565)
2D chemical structure image of ab120565, Dopamine hydrochloride, Endogenous neurotransmitter
Functional Studies - Dopamine hydrochloride, Endogenous neurotransmitter (ab120565)
ab32088 staining MEK1 (phospho S218 + S222) in SKNSH cells treated with dopamine hydrochloride (ab120565), by ICC/IF. Increase in MEK1 (phospho S218 + S222) expression correlates with increased concentration of dopamine hydrochloride, as described in literature.
The cells were incubated at 37°C for 24h in media containing different concentrations of ab120565 (dopamine hydrochloride) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab32088 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
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