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AB142166

Doramapimod, p38 MAPK inhibitor

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(2 Publications)

MW 527.7 Da, Purity >98%. Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.
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Chemical Structure - Doramapimod, p38 MAPK inhibitor (AB142166)
  • Chemical Structure

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Chemical Structure - Doramapimod, p38 MAPK inhibitor (AB142166)

2D chemical structure image of ab142166, Doramapimod, p38 MAPK inhibitor

Key facts

CAS number

285983-48-4

Purity

>98%

Form

Solid

form

Molecular weight

527.7 Da

Molecular formula

C<sub>3</sub><sub>1</sub>H<sub>3</sub><sub>7</sub>N<sub>5</sub>O<sub>3</sub>

PubChem

156422

Nature

Synthetic

Solubility

Soluble in DMSO to 100 mM

Soluble in ethanol to 50 mM

Biochemical name

Doramapimod

Biological description

Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.

Canonical smiles

CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

InChi

InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)

InChiKey

MVCOAUNKQVWQHZ-UHFFFAOYSA-N

IUPAC Name

1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Glia 70:1850-1863 PubMed35635122

2022

CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microglia.

Applications

Unspecified application

Species

Unspecified reactive species

Maria P Ivshina,Heleen M van 't Spijker,Suna Jung,Sithara Raju Ponny,Dorothy P Schafer,Joel D Richter

Glia 69:1478-1493 PubMed33556209

2021

Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Maria Fe Lanfranco,Jordy Sepulveda,Gregory Kopetsky,G William Rebeck
View all publications
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