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MW 527.7 Da, Purity >98%. Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.
- CAS number
285983-48-4
- Purity
> 98%
- Form
Solid
- Molecular weight
527.7 Da
- Molecular formula
C31H37N5O3
- PubChem identifier
156422
- Nature
Synthetic
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MW 527.7 Da, Purity >98%. Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.
Key facts
- CAS number
285983-48-4
- Purity
> 98%
- Form
Solid
- Molecular weight
527.7 Da
- Molecular formula
C31H37N5O3
- PubChem identifier
156422
- Nature
Synthetic
- Biochemical name
Doramapimod
- Biological description
Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.
- Canonical SMILES
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
- InChI
InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
- InChIKey
MVCOAUNKQVWQHZ-UHFFFAOYSA-N
- IUPAC name
1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
Storage
- Shipped at conditions
Ambient - Can Ship with Ice
- Appropriate long-term storage conditions
-20°C
- Storage information
Store under desiccating conditions
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