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MW 527.7 Da, Purity >98%. Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.

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Images

Chemical Structure - Doramapimod, p38 MAPK inhibitor (AB142166), expandable thumbnail

Publications

Key facts

CAS number
285983-48-4
Purity
> 98%
Form
Solid
Molecular weight
527.7 Da
Molecular formula
C31H37N5O3
PubChem identifier
156422
Nature
Synthetic

Target data

Recommended products

MW 527.7 Da, Purity >98%. Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.

Key facts

Purity
> 98%
PubChem identifier
156422
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 50 mM.

Biochemical name
Doramapimod
Biological description

Potent, selective, cell permeable p38 MAPK inhibitor (IC50 values of 38 nM, 65 nM, 200 nM and 520 nM for p38α/β/γ/δ respectively in vitro; Kd for p38α = 0.1 nM). Anti-inflammatory activity in vivo.

Canonical SMILES
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
InChI
InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
InChIKey
MVCOAUNKQVWQHZ-UHFFFAOYSA-N
IUPAC name
1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions

Product promise

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1 product image

  • Chemical Structure - Doramapimod, p38 MAPK inhibitor (ab142166), expandable thumbnail

    Chemical Structure - Doramapimod, p38 MAPK inhibitor (ab142166)

    2D chemical structure image of ab142166, Doramapimod, p38 MAPK inhibitor

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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