JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB146597

Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor

Be the first to review this product! Submit a review

|

(5 Publications)

MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).
1 Images
Chemical Structure - Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor (AB146597)
  • Chemical Structure

Lab

Chemical Structure - Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor (AB146597)

2D chemical structure image of ab146597, Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor

Key facts

CAS number

866405-64-3

Purity

>99%

Form

Liquid

form

Molecular weight

399.5 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>5</sub>N<sub>5</sub>O

PubChem

11524144

Nature

Synthetic

Biochemical name

Dorsomorphin

Biological description

Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821)

Canonical smiles

C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

InChi

InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChiKey

XHBVYDAKJHETMP-UHFFFAOYSA-N

IUPAC Name

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

style
left-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB32047

Anti-AMPK alpha 1 antibody [Y365]

RabMAb|Recombinant|KO Validated|Lab Essentials|20ul selling size

Western blot - Anti-AMPK alpha 1 antibody [Y365] (AB32047)

  • 5
  • 6
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB8227

Anti-beta Actin antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Western blot - Anti-beta Actin antibody - Loading Control (AB8227)

  • 5
  • 104
style
left-column

Product details

Supplied in DMSO (10mM).

A natural process can cause the product to crystallize out of solution. Should it happen, it is advised to heat the solution to approximately 55°C and let it cool down before use.

style
left-column

Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store in the dark|Store under desiccating conditions|This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes
style
left-column
style
left-column
style
left-column

Product protocols

style
left-column

Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Liver cancer 14:36-57 PubMed40144470

2025

The Impact of TP53-Induced Glycolysis and Apoptosis Regulator on Prognosis in Hepatocellular Carcinoma: Association with Tumor Microenvironment and Ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Katsuya Toshida,Shinji Itoh,Norifumi Iseda,Shugo Tanaka,Kensuke Nakazono,Takahiro Tomiyama,Shohei Yoshiya,Takeo Toshima,Noboru Harada,Kenichi Kohashi,Koji Taniguchi,Yoshinao Oda,Tomoharu Yoshizumi

Frontiers in pharmacology 11:712 PubMed32499702

2020

Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Haixiao Liu,Wei Guo,Hao Guo,Lei Zhao,Liang Yue,Xia Li,Dayun Feng,Jianing Luo,Xun Wu,Wenxing Cui,Yan Qu

Scientific reports 9:18859 PubMed31827136

2019

Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation.

Applications

Unspecified application

Species

Unspecified reactive species

Hiroaki Fujiwara,Keisuke Tateishi,Kento Misumi,Akimasa Hayashi,Kaori Igarashi,Hiroyuki Kato,Takuma Nakatsuka,Nobumi Suzuki,Keisuke Yamamoto,Yotaro Kudo,Yoku Hayakawa,Hayato Nakagawa,Yasuo Tanaka,Hideaki Ijichi,Hirofumi Kogure,Yosuke Nakai,Hiroyuki Isayama,Kiyoshi Hasegawa,Masashi Fukayama,Tomoyoshi Soga,Kazuhiko Koike

Nature medicine 24:1568-1578 PubMed30127391

2018

Genetically engineered human cortical spheroid models of tuberous sclerosis.

Applications

Unspecified application

Species

Unspecified reactive species

John D Blair,Dirk Hockemeyer,Helen S Bateup

Brain research bulletin 139:105-113 PubMed29452253

2018

Remote limb ischemic postconditioning protects against cerebral ischemia-reperfusion injury by activating AMPK-dependent autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Guo,Lei Zhao,Bodong Wang,Xia Li,Hao Bai,Haixiao Liu,Liang Yue,Wei Guo,Zhenyuan Bian,Li Gao,Dayun Feng,Yan Qu
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com