Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor

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(5 Publications)

MW 399.5 Da, Purity >99%. Potent, selective and reversible inhibitor of AMP-kinase (K_i = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821).

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10q23del, 1300015D22Rik, 5 AMP activated protein kinase alpha 1catalytic subunit, 5 AMP activated protein kinase catalytic alpha 1 chain, 5 AMP activated protein kinase subunit gamma 3, 5' AMP activated protein kinase gamma 1 subunit, 5' AMP activated protein kinase beta 2 subunit, 5' AMP activated protein kinase subunit beta 2, 5' AMP activated protein kinase subunit gamma 1, 5''-AMP-activated protein kinase subunit beta-1, 5''-AMP-activated protein kinase subunit beta-2, 5''-AMP-activated protein kinase subunit gamma-1, 5''-AMP-activated protein kinase subunit gamma-2, 5''-AMP-activated protein kinase subunit gamma-3, 5'-AMP-activated protein kinase beta-1 subunit, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase catalytic subunit alpha-2, AAKB1_HUMAN, AAKB2_HUMAN, AAKG, AAKG1_HUMAN, AAKG2_HUMAN, AAKG3_HUMAN, AAPK1_HUMAN, AAPK2_HUMAN, AAT 5, AAT3, ACACA kinase, ACTR-I, ACVR1A, ACVR1_HUMAN, ACVRLK 3, ACVRLK 4, ACVRLK2, AI194361, AI450832, AL024255, ALK 6, ALK-2, ALK-3, ALK-5, AMP activated protein kinase beta 2 non catalytic subunit, AMP activated protein kinase noncatalytic gamma 1 subunit, AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1, AMP-activate kinase alpha 1 subunit, AMP-activated protein kinase beta subunit, AMP-activated protein kinase, catalytic, alpha -1, AMP-activated, noncatalytic, beta-1, AMPK, AMPK 1, AMPK alpha 1, AMPK alpha 1 chain, AMPK alpha 2 chain, AMPK beta 1 chain, AMPK beta 2, AMPK beta 2 chain, AMPK gamma 1 chain, AMPK gamma 3 chain, AMPK gamma1, AMPK gamma2, AMPK gamma3, AMPK subunit alpha-1, AMPK subunit alpha-2, AMPK subunit beta-1, AMPK subunit beta-2, AMPK subunit gamma-1, AMPK subunit gamma-2, AMPK subunit gamma-3, AMPK-BETA-1, AMPK2, AMPKG3, AMPKa1, AMPKa2, AMPKalpha2, AMPKb, AMPKg, ARCC2, ASV, AU021155, AW259666, AW545284, Acetyl-CoA carboxylase kinase, Activin A receptor type I, Activin A receptor type II like kinase, Activin A receptor type II like kinase 2, Activin A receptor type II like kinase 3, Activin A receptor type II like kinase 53kDa, Activin A receptor type II like kinase, 53kD, Activin receptor like kinase 6, Activin receptor type I, Activin receptor type-1, Activin receptor-like kinase 2, Activin receptor-like kinase 3, Activin receptor-like kinase 5, Acvrlk6, Avian sarcoma virus, BMP type II receptor, BMP type-1A receptor, BMP type-1B receptor, BMP type-2 receptor, BMP-2B, BMP2B1, BMP4_HUMAN, BMPR 3, BMPR IB, BMPR-II, BMPR2_HUMAN, BMR 2, BMR1A_HUMAN, BMR1B_HUMAN, BR 1a, BR 1b, BRK 3, Bmpr, Bone morphogenetic protein 2B, Bone morphogenetic protein 4, Bone morphogenetic protein receptor type IA, Bone morphogenetic protein receptor type IA precursor, Bone morphogenetic protein receptor type IB, Bone morphogenetic protein receptor type II, Bone morphogenetic protein receptor type-1A, Bone morphogenetic protein receptor type-1B, Bone morphogenetic protein receptor type-2, Bone morphogenic protein receptor type II serine threonine kinase, C SRC, C130083N04Rik, CD 135, CD 292, CD135 antigen, CD292 antigen, CD309, CD309 antigen, CDNA FLJ14219 fis clone NT2RP3003800 highly similar to Rattus norvegicus tyrosine protein kinase pp60 c src mRNA, CDw 293, CDw293 antigen, CFK 43a, CMH6, CTPA, CTPP1, CTRCT6, Cellular Yes 1 protein, DVR4, E430008F22, EC 2.7.10.1, EC 2.7.10.2, EC 2.7.11.1, EC 2.7.11.30, ECK, EPH Receptor A2, EPHA2_HUMAN, Ephrin receptor, Ephrin receptor EphA2, Ephrin type-A receptor 2, Epithelial cell kinase, Epithelial cell receptor protein tyrosine kinase, FAA3, FL cytokine receptor, FLK-1, FLK1, mouse, homolog of, FLT, FLT3_HUMAN, FOP, FRT, Fetal liver kinase 1, Fetal liver kinase 2, Flk 2, Flt-1, Fms related tyrosine kinase 1, Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor, Fms related tyrosine kinase 3, Fms-like tyrosine kinase 1, Fms-like tyrosine kinase 3, Growth factor receptor tyrosine kinase type III, H91620p, HAMPKb, HMG CoA reductase kinase, HMGCR kinase, HsT441, Hydroxyalkyl protein kinase, Hydroxymethylglutaryl-CoA reductase kinase, IMD22, KRD1, Kdr, Kinase insert domain receptor, Kinase insert domain receptor (a type III receptor tyrosine kinase), LCK proto-oncogene, Src family tyrosine kinase, LCK_HUMAN, LDS1A, LDS1B, LDS2, LDS2A, LDS2B, LSK, Lck p56, Leukocyte C-terminal Src kinase, Ly-72, Ly73, Lymphocyte cell-specific protein-tyrosine kinase, Lymphocyte specific protein tyrosine kinase, MAP kinase interacting kinase 1, MAP kinase interacting serine/threonine kinase 1, MAP kinase signal-integrating kinase 1, MAP kinase-interacting serine/threonine-protein kinase 1, MAPK signal integrating kinase 1, MCOPS6, MFS2, MGC100779, MGC17785, MGC33776, MGC57364, MGC61468, MGC8666, MITOGEN-ACTIVATED PROTEIN KINASE-INTERACTING SERINE/THREONINE KINASE 1, MKNK1_HUMAN, MSSE, Membrane associated protein tyrosine kinase, Myk 2, Neuronal CSRC tyrosine specific protein kinase, Neuronal SRC, Neuronal proto-oncogene tyrosine-protein kinase Src, OFC11, OTTHUMP0000004234, OTTHUMP00000161795, OTTHUMP00000161796, OTTHUMP00000174476, OTTHUMP00000174477, Oncogene SRC, Oncogene lck, PPH 1, PRKAA, PRKAA 1, PRKAA2, PRKAB 2, PRKAB1, PRKAG 1, PRKAG3, Prkag2, Protein YT16, Protein kinase AMP activated alpha 1 catalytic subunit, Protein kinase AMP activated alpha 2 catalytic subunit, Protein kinase AMP activated beta 2 non catalytic subunit, Protein kinase AMP activated catalytic subunit alpha 2, Protein kinase AMP activated gamma 1 non catalytic subunit, Protein kinase AMP activated gamma 2 non catalytic subunit, Protein kinase AMP activated gamma 3 non catalytic subunit, Protein kinase AMP activated non catalytic subunit beta 1, Protein-tyrosine kinase receptor flk-1, Proto oncogene tyrosine protein kinase LCK, Proto oncogene tyrosine protein kinase YES, Proto-oncogene Lck, Proto-oncogene c-Src, Proto-oncogene c-Yes, Proto-oncogene tyrosine-protein kinase Src, Protooncogene SRC, Protooncogene SRC Rous sarcoma, RIIC, Receptor type tyrosine protein kinase FLT3, SKR 4, SKR 5, SKR1, SNF1-like protein AMPK, SNF1A, SRC Oncogene, SRC proto oncogene non receptor tyrosine kinase, SRC_HUMAN, STK-1, Sek-2, Serine threonine kinase type II activin receptor like kinase, Serine threonine protein kinase receptor R5, Serine threonine protein kinase receptor R5 precursor, Serine/threonine receptor kinase, Serine/threonine-protein kinase receptor R1, Serine/threonine-protein kinase receptor R4, Serine/threonine-protein kinase receptor R5, Soluble EPHA2 variant 1, Soluble VEGF receptor 1 14, Soluble VEGFR1 variant 2, Soluble VEGFR1 variant 21, Stem cell tyrosine kinase 1, T ALK, T cell-specific protein-tyrosine kinase, T lymphocyte specific protein tyrosine kinase p56lck, TAAD2, TGF beta receptor type IIB, TGF-B superfamily receptor type I, TGF-beta receptor type I, TGF-beta receptor type II, TGF-beta receptor type-1, TGF-beta receptor type-2, TGF-beta type I receptor, TGF-beta type II receptor, TGF-beta-R2, TGFB R2, TGFBR 1, TGFBR1 protein, TGFR1_HUMAN, TGFR2_HUMAN, TGFbeta - RII, TSR-I, Tau-protein kinase PRKAA1, TbetaR-I, TbetaR-II, Transforming growth factor beta receptor 1, Transforming growth factor beta receptor I, Transforming growth factor beta receptor I (activin A receptor type II like kinase, 53kD), Transforming growth factor beta receptor II, Transforming growth factor beta receptor type IIC, Transforming growth factor, beta receptor II (70/80kDa), Transforming growth factor-beta receptor type I, Transforming growth factor-beta receptor type II, Type II activin receptor like kinase, Tyrosine kinase growth factor receptor, Tyrosine kinase pp60c src, Tyrosine protein kinase SRC 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase Lck, Tyrosine-protein kinase Yes, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, V src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog (avian), VEGFR, VEGFR-1, VEGFR-2, VGFR1_HUMAN, VGFR2_HUMAN, Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, Vascular endothelial growth factor vascular permeability factor receptor, Vascular permeability factor receptor, Vascular permeability factor receptor 1, Viral oncogene yes 1 homolog 1, WPWS, YES proto oncogene 1, Src family tyrosine kinase, YES1 proto oncogene, Src family tyrosine kinase, YES_HUMAN, YT 16, Yamaguchi sarcoma oncogene, Yes 1, ZYME, activin A receptor type II-like protein kinase of 53kD, alk6tr, c Yes, cb116, hormone sensitive lipase kinase, im:7154392, kinase AMPK alpha1, p56(LSTRA) protein tyrosine kinase, p56-LCK, p60-Src, p60c-src, p61-Yes, pp58 lck, pp60c-src, protein kinase, AMP-activated, beta 1 non-catalytic subunit, protein kinase, AMP-activated, noncatalytic gamma-1, protein kinase, AMP-activated, noncatalytic, beta-1, soluble VEGFR2, transforming growth factor, beta receptor II alpha, transforming growth factor, beta receptor II beta, transforming growth factor, beta receptor II delta, transforming growth factor, beta receptor II epsilon, transforming growth factor, beta receptor II gamma, v src avian sarcoma (Schmidt Ruppin A2) viral oncogene homolog, v src sarcoma (Schmidt Ruppin A 2) viral oncogene homolog avian, v yes 1 Yamaguchi sarcoma viral oncogene homolog 1, wu:fa94c10, zALK 6, zBMPR IA, zbmp-4, zgc:100779