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AB144821

Dorsomorphin dihydrochloride, AMP-kinase inhibitor

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(4 Publications)

MW 472.4 Da, Purity >99%. Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo. .

Key facts

CAS number

1219168-18-9

Purity

>99%

Form

Solid

form

Molecular weight

472.4 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>2</sub><sub>7</sub>Cl<sub>2</sub>N<sub>5</sub>O

PubChem

49761481

Nature

Synthetic

Solubility

Soluble in water to 100 mM

Biochemical name

Dorsomorphin dihydrochloride

Biological description

Potent, selective, reversible AMP-kinase inhibitor (Ki = 109 nM). BMP type I receptor inhibitor. Induce autophagy in cancer cells independent of AMPK inhibition. Promotes cardiomyogenesis in embryonic stem cells. Reduces hepcidin, VCAM-1 and ICAM-1 expression in vivo.

Canonical smiles

C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3.Cl.Cl

InChi

InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H

InChiKey

RJDVIJJQKMGPMV-UHFFFAOYSA-N

IUPAC Name

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine;dihydrochloride

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 10:3939 PubMed32127560

2020

Development of genetic quality tests for good manufacturing practice-compliant induced pluripotent stem cells and their derivatives.

Applications

Unspecified application

Species

Unspecified reactive species

Hye-Yeong Jo,Hyo-Won Han,Inuk Jung,Ji Hyeon Ju,Soon-Jung Park,Sunghwan Moon,Dongho Geum,Hyemin Kim,Han-Jin Park,Sun Kim,Glyn N Stacey,Soo Kyung Koo,Mi-Hyun Park,Jung-Hyun Kim

The journals of gerontology. Series A, Biological sciences and medical sciences 75:278-285 PubMed31198956

2019

The Effects of Metformin on Age-Related Changes in the Liver Sinusoidal Endothelial Cell.

Applications

Unspecified application

Species

Unspecified reactive species

Nicholas J Hunt,Glen P Lockwood,Sun Woo Sophie Kang,Tamara Pulpitel,Ximonie Clark,Hong Mao,Peter A G McCourt,Gregory J Cooney,Jibran A Wali,Frank H Le Couteur,David G Le Couteur,Victoria C Cogger

American journal of physiology. Lung cellular and molecular physiology 316:L20-L34 PubMed30260287

2018

Transforming growth factor-β downregulates sGC subunit expression in pulmonary artery smooth muscle cells via MEK and ERK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Lili Du,Jesse D Roberts

American journal of physiology. Lung cellular and 313:L615-L627 PubMed28642261

2017

Transforming growth factor-β stimulates Smad1/5 signaling in pulmonary artery smooth muscle cells and fibroblasts of the newborn mouse through ALK1.

Applications

Unspecified application

Species

Unspecified reactive species

Huili Zhang,Lili Du,Ying Zhong,Kathleen C Flanders,Jesse D Roberts
View all publications
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