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AB216312

Dovitinib, class III-V receptor tyrosine kinase inhibitor

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MW 392.4 Da, Purity >99%. Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.
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Chemical Structure - Dovitinib, class III-V receptor tyrosine kinase inhibitor (AB216312)
  • Chemical Structure

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Chemical Structure - Dovitinib, class III-V receptor tyrosine kinase inhibitor (AB216312)

2D chemical structure image of ab216312, Dovitinib, class III-V receptor tyrosine kinase inhibitor

Key facts

Purity

>99%

Form

Solid

form

Molecular weight

392.4 Da

Molecular formula

C<sub>2</sub><sub>1</sub>H<sub>2</sub><sub>1</sub>FN<sub>6</sub>O

PubChem

9886808

Nature

Synthetic

Solubility

Soluble in DMSO (up to 30 mg/ml)

Biochemical name

CID 9886808

Biological description

Potent, selective inhibitor of class III-V receptor tyrosine kinases (RTKs). Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 values are 10 nM, 13 nM and 8 nM respectively), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM). Selectively blocks growth of B9 cells transformed by wild type, or activated mutant FGFR3. Induces apoptosis, or sensitizes cells to induction of apoptosis by other means in a variety of cancer cell lines.

Canonical smiles

CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3

Isomeric smiles

CN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C/4\C(=C5C(=NC4=O)C=CC=C5F)N)/N3

InChi

InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3/b20-18-

InChiKey

KCOYQXZDFIIGCY-ZZEZOPTASA-N

IUPAC Name

(3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one

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Complementary Products

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Primary Antibodies

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Anti-DAB2 antibody [EPR22881-69]

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Western blot - Anti-DAB2 antibody [EPR22881-69] (AB256524)

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP21A2 antibody (AB232701)

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Primary Antibodies

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Anti-MMP9 antibody [RM1020]

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Product promise

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