MW 1025.9 Da, Purity >97%. Synthetic tetracycline; matrix metalloprotease (MMP) inhibitor. Inhibits tumour growth, suppresses cell proliferation and induces apoptosis in vitro and in vivo.
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- Nature methods 20:1887-18992023RNA molecular recording with an engineered RNA deaminase.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYizhu Lin,Samentha Kwok,Abigail E Hein,Bao Quoc Thai,Yewande Alabi,Megan S Ostrowski,Ke Wu,Stephen N FloorPubMed 37857907
- The Journal of cell biology 222:2023A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKlara I Jansen,Malina K Iwanski,Mithila Burute,Lukas C KapiteinPubMed 36880745
- Current biology : CB 32:4660-4674.e62022Opto-katanin, an optogenetic tool for localized, microtubule disassembly.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJoyce C M Meiring,Ilya Grigoriev,Wilco Nijenhuis,Lukas C Kapitein,Anna AkhmanovaPubMed 36174574
- Cellular and molecular life sciences : CMLS 79:4202022Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChia-Chun Chang,Min Peng,Jiale Zhong,Ziheng Zhang,Gerson Dierley Keppeke,Li-Ying Sung,Ji-Long LiuPubMed 35833994
- Human molecular genetics 31:2121-21362022The renal inflammatory network of nephronophthisis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarceau Quatredeniers,Frank Bienaimé,Giulia Ferri,Pierre Isnard,Esther Porée,Katy Billot,Eléonore Birgy,Manal Mazloum,Salomé Ceccarelli,Flora Silbermann,Simone Braeg,Thao Nguyen-Khoa,Rémi Salomon,Marie-Claire Gubler,E Wolfgang Kuehn,Sophie Saunier,Amandine ViauPubMed 35043953
- The Journal of cell biology 219:2020An optimized toolbox for the optogenetic control of intracellular transport.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWilco Nijenhuis,Mariëlle M P van Grinsven,Lukas C KapiteinPubMed 32328628
- Cancer research 80:2722-27362020Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJian Pan et. al.PubMed 32332020
- Journal of the American Society of Nephrology : JA 31:1035-10492020Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAmandine Viau et. al.PubMed 32238474
Key facts
- CAS number
- 24390-14-5
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 1025.9 Da
- Molecular formula
- C46H58Cl2N4O18
- PubChem identifier
- 54686183
- Nature
- Synthetic
Target data
Recommended products
MW 1025.9 Da, Purity >97%. Synthetic tetracycline; matrix metalloprotease (MMP) inhibitor. Inhibits tumour growth, suppresses cell proliferation and induces apoptosis in vitro and in vivo.
Key facts
- CAS number
- 24390-14-5
- Purity
- > 97%
- Form
- Solid
- Molecular weight
- 1025.9 Da
- Molecular formula
- C46H58Cl2N4O18
- PubChem identifier
- 54686183
- Nature
- Synthetic
- Solubility
Soluble in water to 100 mM.
Soluble in DMSO to 100 mM.
- Biochemical name
- Doryx
- Biological description
Synthetic tetracycline; matrix metalloprotease (MMP) inhibitor. Inhibits tumour growth, suppresses cell proliferation and induces apoptosis in vitro and in vivo.
- Canonical SMILES
- CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
- Isomeric SMILES
- CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
- InChI
- InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
- InChIKey
- UHHHTIKWXBRCLT-VDBOFHIQSA-N
- IUPAC name
- (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Product promise
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1 product image
Chemical Structure - Doxycycline hyclate, matrix metalloprotease inhibitor (ab141091)
2D chemical structure image of ab141091, Doxycycline hyclate, matrix metalloprotease inhibitor
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