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AB141091

Doxycycline hyclate, matrix metalloprotease inhibitor

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(9 Publications)

MW 512.94 g/mol, Purity >97%. Synthetic tetracycline; matrix metalloprotease (MMP) inhibitor. Inhibits tumour growth, suppresses cell proliferation and induces apoptosis in vitro and in vivo.
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Chemical Structure - Doxycycline hyclate, matrix metalloprotease inhibitor (AB141091)
  • Chemical Structure

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Chemical Structure - Doxycycline hyclate, matrix metalloprotease inhibitor (AB141091)

2D chemical structure image of ab141091, Doxycycline hyclate, matrix metalloprotease inhibitor

Key facts

Purity

>97%

Form

Solid

form

Molecular weight

512.94 g/mol

Nature

Synthetic

Biological description

Synthetic tetracycline; matrix metalloprotease (MMP) inhibitor. Inhibits tumour growth, suppresses cell proliferation and induces apoptosis in vitro and in vivo.

Isomeric smiles

Cl.Cl.O.CCO.NC(=O)C=3C(=O)[C@@]4(O)C(O)=C2C(=O)c1c(O)cccc1[C@H](C)[C@H]2[C@H](O)[C@H]4[C@H](N(C)C)C=3O.NC(=O)C=3C(=O)[C@@]4(O)C(O)=C2C(=O)c1c(O)cccc1[C@H](C)[C@H]2[C@H](O)[C@H]4[C@@H](C=3O)N(C)C

InChi

InChI=1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1

InChiKey

HALQELOKLVRWRI-VDBOFHIQSA-N

IUPAC Name

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hyclate

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
Storage information
Store under desiccating conditions|The product can be stored for up to 12 months
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Product protocols

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Publications (9)

Recent publications for all applications. Explore the full list and refine your search

Nature 638:805-813 PubMed39542025

2024

Engineered receptors for soluble cellular communication and disease sensing.

Applications

Unspecified application

Species

Unspecified reactive species

Dan I Piraner,Mohamad H Abedi,Maria J Duran Gonzalez,Adam Chazin-Gray,Annie Lin,Iowis Zhu,Pavithran T Ravindran,Thomas Schlichthaerle,Buwei Huang,Tyler H Bearchild,David Lee,Sarah Wyman,Young-Wook Jun,David Baker,Kole T Roybal

Nature methods 20:1887-1899 PubMed37857907

2023

RNA molecular recording with an engineered RNA deaminase.

Applications

Unspecified application

Species

Unspecified reactive species

Yizhu Lin,Samentha Kwok,Abigail E Hein,Bao Quoc Thai,Yewande Alabi,Megan S Ostrowski,Ke Wu,Stephen N Floor

The Journal of cell biology 222: PubMed36880745

2023

A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle.

Applications

Unspecified application

Species

Unspecified reactive species

Klara I Jansen,Malina K Iwanski,Mithila Burute,Lukas C Kapitein

Current biology : CB 32:4660-4674.e6 PubMed36174574

2022

Opto-katanin, an optogenetic tool for localized, microtubule disassembly.

Applications

Unspecified application

Species

Unspecified reactive species

Joyce C M Meiring,Ilya Grigoriev,Wilco Nijenhuis,Lukas C Kapitein,Anna Akhmanova

Cellular and molecular life sciences : CMLS 79:420 PubMed35833994

2022

Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation.

Applications

Unspecified application

Species

Unspecified reactive species

Chia-Chun Chang,Min Peng,Jiale Zhong,Ziheng Zhang,Gerson Dierley Keppeke,Li-Ying Sung,Ji-Long Liu

Human molecular genetics 31:2121-2136 PubMed35043953

2022

The renal inflammatory network of nephronophthisis.

Applications

Unspecified application

Species

Unspecified reactive species

Marceau Quatredeniers,Frank Bienaimé,Giulia Ferri,Pierre Isnard,Esther Porée,Katy Billot,Eléonore Birgy,Manal Mazloum,Salomé Ceccarelli,Flora Silbermann,Simone Braeg,Thao Nguyen-Khoa,Rémi Salomon,Marie-Claire Gubler,E Wolfgang Kuehn,Sophie Saunier,Amandine Viau

The Journal of cell biology 219: PubMed32328628

2020

An optimized toolbox for the optogenetic control of intracellular transport.

Applications

Unspecified application

Species

Unspecified reactive species

Wilco Nijenhuis,Mariëlle M P van Grinsven,Lukas C Kapitein

Cancer research 80:2722-2736 PubMed32332020

2020

Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Pan,Tiago C Silva,Nicole Gull,Qian Yang,Jasmine T Plummer,Stephanie Chen,Kenji Daigo,Takao Hamakubo,Sigal Gery,Ling-Wen Ding,Yan-Yi Jiang,Shaoyan Hu,Li-Yan Xu,En-Min Li,Yanbing Ding,Samuel J Klempner,Simon A Gayther,Benjamin P Berman,H Phillip Koeffler,De-Chen Lin

Journal of the American Society of Nephrology : JA 31:1035-1049 PubMed32238474

2020

Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Amandine Viau,Maroua Baaziz,Amandine Aka,Manal Mazloum,Clément Nguyen,E Wolfgang Kuehn,Fabiola Terzi,Frank Bienaimé
View all publications
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