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AB120396

DPCPX, A1 antagonist

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(15 Publications)

MW 304.39 Da, Purity >99%. Potent A1antagonist (Ki = 0.45 nM). Also exhibits antagonism at A2B receptors (pA2 = 7.16, for human A2B expressed in CHO cells).

View Alternative Names

A1AR, A1R, AA1R_HUMAN, AA2BR_HUMAN, ADORA 1, ADORA 2, Adenosine receptor A1, Adenosine receptor A2b, HGNC:264, Netrin 1 receptor, RDC 7, Ri, adora 2b

1 Images
Chemical Structure - DPCPX, A1 antagonist (AB120396)
  • Chemical Structure

Lab

Chemical Structure - DPCPX, A1 antagonist (AB120396)

2D chemical structure image of ab120396, DPCPX, A1 antagonist

Key facts

CAS number

102146-07-6

Purity

>99%

Form

Solid

form

Molecular weight

304.39 Da

Molecular formula

C<sub>1</sub><sub>6</sub>H<sub>2</sub><sub>4</sub>N<sub>4</sub>O<sub>2</sub>

PubChem

1329

Nature

Synthetic

Solubility

Soluble in ethanol to 10 mM

Soluble in DMSO to 5 mM

Biochemical name

8-Cyclopentyl-1,3-dipropylxanthine

Biological description

Potent A1antagonist (Ki = 0.45 nM). Also exhibits antagonism at A2B receptors (pA2 = 7.16, for human A2B expressed in CHO cells).

Canonical smiles

CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CCCC3

InChi

InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)

InChiKey

FFBDFADSZUINTG-UHFFFAOYSA-N

IUPAC Name

8-cyclopentyl-1,3-dipropyl-7H-purine-2,6-dione

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Complementary Products

Biochemicals

AB120398

N6-Cyclopentyladenosine (CPA), A1 agonist

Chemical Structure - N6-Cyclopentyladenosine (CPA), A1 agonist (AB120398)

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Sample Prep & Detection Kits

AB201795

Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link®

ELISA - Biotinylation Kit / Biotin Conjugation Kit (Fast, Type A) - Lightning-Link® (AB201795)

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Assay Kits

AB181421

Human TNF alpha ELISA Kit

KO Validated|Recombinant|SimpleStep

Sandwich ELISA - Human TNF alpha ELISA Kit (AB181421)

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Biochemicals

AB120337

CGP 55845 hydrochloride, GABAB antagonist

Functional Studies - CGP 55845 hydrochloride, GABAB antagonist (AB120337)

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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
Ambient
Appropriate long-term storage conditions
Ambient
Storage information
The product can be stored for up to 12 months
Handling instructions

Need more advice on solubility, usage and handling? Please visit our our product support page for more details.

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Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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Refer to SDS for further information.

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Adenosine A1 Receptor also known as ADORA1 and the Adenosine A2b Receptor known as ADORA2B are important protein receptors in the body. Mechanically they belong to the G protein-coupled receptor (GPCR) family involved in a variety of cellular responses to adenosine. The A1 receptor generally inhibits adenylate cyclase activity whereas A2b receptor stimulates it. Both receptors have a substantial presence in the central nervous system as well as in the heart and kidneys. The approximate mass of the A1 receptor is 37 kDa while A2b receptor is around 36 kDa.
Biological function summary

The adenosine receptors A1 and A2b regulate diverse physiological processes. They do not form part of larger protein complexes but act mainly by interacting with G proteins to modulate intracellular signaling pathways. The A1 receptor typically influences neurotransmitter release heart rate modulation and renal blood flow while A2b receptor has roles in inflammatory responses and vascular relaxation. These receptors are important for fine-tuning many cellular functions and systemic processes.

Pathways

Both the Adenosine A1 and A2b receptors are central to the adenosine signaling pathway and the cAMP pathway. They interact with proteins like adenylate cyclase and phospholipase C in these pathways. The A1 receptor's inhibition of adenylate cyclase leads to reduced cyclic AMP generation while the A2b receptor's stimulation increases cAMP levels. This affects downstream pathways including protein kinase A (PKA) and extracellular signal-regulated kinases (ERK) which play parts in various cellular functions and responses.

Adenosine A1 and A2b receptors have been linked to conditions such as cardiovascular diseases and asthma. The A1 receptor is associated with ischemic conditions in the heart where its modulation might protect against cardiac damage. In contrast the A2b receptor has a known connection to asthma as it affects inflammatory processes in airway tissues. These receptors interact with proteins like phospholipase C and adenylate cyclase which mediate significant responses in these disorders. Understanding these interactions helps in developing therapeutic strategies including the use of A1 antagonists like DPCPX or other chemical antagonists specific to these receptors.
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Product protocols

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:6340 PubMed39068155

2024

Adenosine triggers early astrocyte reactivity that provokes microglial responses and drives the pathogenesis of sepsis-associated encephalopathy in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Qilin Guo,Davide Gobbo,Na Zhao,Hong Zhang,Nana-Oye Awuku,Qing Liu,Li-Pao Fang,Tanja M Gampfer,Markus R Meyer,Renping Zhao,Xianshu Bai,Shan Bian,Anja Scheller,Frank Kirchhoff,Wenhui Huang

CNS neuroscience & therapeutics 29:2597-2607 PubMed37017409

2023

Deep brain stimulation suppresses epileptic seizures in rats via inhibition of adenosine kinase and activation of adenosine A1 receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Pandeng Xie,Siqi Liu,Qi Huang,Zhonghua Xiong,Jiahui Deng,Chongyang Tang,Ke Xu,Bo Zhang,Baijian He,Xiongfei Wang,Zhao Liu,Jing Wang,Jian Zhou,Yugang Guan,Guoming Luan,Tianfu Li,Feng Zhai

Journal of cellular and molecular medicine 25:2931-2943 PubMed33523568

2021

Inhibition of adenosine kinase attenuates myocardial ischaemia/reperfusion injury.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Wang,Bailu Wang,Shukun Sun,Shengchuan Cao,Xiaoxuan Zhai,Chuanxin Zhang,Qun Zhang,Qiuhuan Yuan,Yi Sun,Mengyang Xue,Jingjing Ma,Feng Xu,Shujian Wei,Yuguo Chen

Neural regeneration research 15:712-723 PubMed31638096

2019

Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Cheng Lv,An-Bo Gao,Jing Yang,Li-Yuan Zhong,Bo Jia,Shu-Hui Ouyang,Le Gui,Tian-Hong Peng,Sha Sun,Francisco S Cayabyab

Biochemical and biophysical research communication 497:850-856 PubMed29454963

2018

Adenosine receptors enhance the ATP-induced odontoblastic differentiation of human dental pulp cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaosong Yi,Wei Wang,Qiufei Xie

Cellular physiology and biochemistry : internation 43:733-742 PubMed28950257

2017

The Adenosine A1 Receptor Antagonist DPCPX Inhibits Tumor Progression via the ERK/JNK Pathway in Renal Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yihong Zhou,Liang Tong,Xi Chu,Fei Deng,Jin Tang,Yuxin Tang,Yingbo Dai

Cell journal 19:386-402 PubMed28836401

2017

Purinergic Receptor Expression and Potential Association with Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Development.

Applications

Unspecified application

Species

Unspecified reactive species

Shirin Kashfi,Maryam Peymani,Kamran Ghaedi,Hossein Baharvand,Mohammad Hossein Nasr-Esfahani,Mohammad Javan

The Journal of neuroscience : the official journal of the Society for Neuroscience 36:12117-12128 PubMed27903722

2016

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity.

Applications

Unspecified application

Species

Unspecified reactive species

Ursula S Sandau,Mariana Colino-Oliveira,Abbie Jones,Bounmy Saleumvong,Shayla Q Coffman,Long Liu,Catarina Miranda-Lourenço,Cátia Palminha,Vânia L Batalha,Yiming Xu,Yuqing Huo,Maria J Diógenes,Ana M Sebastião,Detlev Boison

PloS one 10:e0134488 PubMed26252389

2015

Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.

Applications

Unspecified application

Species

Unspecified reactive species

David Acton,Gareth B Miles

Neuroscience 246:301-11 PubMed23685165

2013

Evidence for constitutive protein synthesis in hippocampal LTP stabilization.

Applications

Unspecified application

Species

Unspecified reactive species

A-K Abbas
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