MW 239.27 Da, Purity >99%. Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.
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- Scientific reports 7:434592017ESR1 inhibits hCG-induced steroidogenesis and proliferation of progenitor Leydig cells in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYeong Seok Oh et. al.PubMed 28266530
Key facts
- CAS number
- 1428-67-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 239.27 Da
- Molecular formula
- C15H13NO2
- PubChem identifier
- 102614
- Nature
- Synthetic
Alternative names
ER-beta, ESR B, ESR BETA, ESR2_HUMAN, ESTR B, Erb, Estrogen Receptor 2, Estrogen receptor 2 (ER beta), Estrogen receptor beta, Estrogen receptor beta 4, NR3A2, Nuclear receptor subfamily 3 group A member 2, estrogen nuclear receptor beta variant a, estrogen nuclear receptor beta variant b
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MW 239.27 Da, Purity >99%. Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.
Key facts
- CAS number
- 1428-67-7
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 239.27 Da
- Molecular formula
- C15H13NO2
- PubChem identifier
- 102614
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
Soluble in ethanol to 100 mM.
- Biochemical name
- 2,3-Bis(4-hydroxyphenyl)propionitrile
- Biological description
Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.
- Canonical SMILES
- C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
- InChI
- InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
- InChIKey
- GHZHWDWADLAOIQ-UHFFFAOYSA-N
- IUPAC name
- 2,3-bis(4-hydroxyphenyl)propanenitrile
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.
- Biological function summary
Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.
- Pathways
Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.
- Associated diseases and disorders
Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.
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Chemical Structure - DPN, ERbeta agonist (ab120166)
2D chemical structure image of ab120166, DPN, ERbeta agonist
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