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MW 239.27 Da, Purity >99%. Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.

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Chemical Structure - DPN, ERbeta agonist (AB120166), expandable thumbnail

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Key facts

CAS number
1428-67-7
Purity
> 99%
Form
Solid
Molecular weight
239.27 Da
Molecular formula
C15H13NO2
PubChem identifier
102614
Nature
Synthetic

Alternative names

Recommended products

MW 239.27 Da, Purity >99%. Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.

Key facts

Purity
> 99%
PubChem identifier
102614
Solubility

Soluble in DMSO to 100 mM.

Soluble in ethanol to 100 mM.

Biochemical name
2,3-Bis(4-hydroxyphenyl)propionitrile
Biological description

Potent, selective ERβ agonist (EC50 values are 0.85 and 66 nM for ERβ and ERα, respectively). Cardioprotective and neuroprotective in vivo.

Canonical SMILES
C1=CC(=CC=C1CC(C#N)C2=CC=C(C=C2)O)O
InChI
InChI=1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
InChIKey
GHZHWDWADLAOIQ-UHFFFAOYSA-N
IUPAC name
2,3-bis(4-hydroxyphenyl)propanenitrile

Storage

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions, The product can be stored for up to 12 months

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

Estrogen Receptor beta (ERβ) also known as ERbeta or beta receptor is an important nuclear receptor involved in mediating the effects of estrogens such as estradiol. This receptor with a molecular weight of approximately 59 kDa resides mainly in endothelial and epithelial tissues and can also be present in the central nervous system. ERβ possesses the ability to bind ligands and translocate to the nucleus where it regulates the transcription of specific target genes.

Biological function summary

Estrogen Receptor beta plays a significant role in cell growth regulation and differentiation. It often forms dimers with Estrogen Receptor alpha (ERα) contributing to the diversity of estrogen signaling responses. As part of the nuclear receptor family ERβ engages in binding with DNA at estrogen response elements influencing various physiological processes. The presence of ERβ in tissues implies it has a potentially protective role possibly balancing the actions of ERα.

Pathways

Estrogen Receptor beta plays an essential role in the estrogen signaling pathway and the apoptosis pathway. Interaction with ERα can influence pathways related to cell proliferation and survival contributing to distinct physiological outcomes. ERβ's involvement with proteins like the retinoic acid receptor within these pathways highlights its impact on controlling gene expression important for cell cycle regulation and programmed cell death.

Associated diseases and disorders

Estrogen Receptor beta has implications in cancers and cardiovascular diseases. In breast cancer ERβ may act differently from ERα possibly providing protective effects against tumor growth. Moreover the receptor's expression affects cardiovascular health by modulating inflammation and vascular function. ERβ interacts with proteins such as p53 hinting at its role in controlling cellular stress responses and combating oncogenesis.

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1 product image

  • Chemical Structure - DPN, ERbeta agonist (ab120166), expandable thumbnail

    Chemical Structure - DPN, ERbeta agonist (ab120166)

    2D chemical structure image of ab120166, DPN, ERbeta agonist

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Product protocols

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