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MW 322.3 Da, Purity >99%. Cell-permeable dynamin inhibitor, that blocks endocytosis. Non-competitively inhibits dynamin1, dynamin2 and mitochondrial dynamin GTPase activity. Selective over other small GTPases.

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Key facts

CAS number

304448-55-3

Purity

> 99%

Form

Solid

Molecular weight

322.3 Da

Molecular formula

C18H14N2O4

PubChem identifier

135533054

Nature

Synthetic

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MW 322.3 Da, Purity >99%. Cell-permeable dynamin inhibitor, that blocks endocytosis. Non-competitively inhibits dynamin1, dynamin2 and mitochondrial dynamin GTPase activity. Selective over other small GTPases.

Key facts

Purity

> 99%

PubChem identifier

135533054

Biochemical name

Dynasore

Biological description

Cell-permeable dynamin inhibitor, that blocks endocytosis. Non-competitively inhibits dynamin1, dynamin2 and mitochondrial dynamin GTPase activity. Selective over other small GTPases.

Canonical SMILES

C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3)O)O)O

Isomeric SMILES

C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3)O)O)O

InChI

InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

InChIKey

SYNDQCRDGGCQRZ-VXLYETTFSA-N

IUPAC name

N-[(E)-(3,4-dihydroxyphenyl)methylideneamino]-3-hydroxynaphthalene-2-carboxamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

-20°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Product promise

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3 product images

  • Chemical Structure - Dynasore, dynamin inhibitor (ab120192), expandable thumbnail

    Chemical Structure - Dynasore, dynamin inhibitor (ab120192)

    2D chemical structure image of ab120192, Dynasore, dynamin inhibitor

  • Immunocytochemistry/ Immunofluorescence - Dynasore, dynamin inhibitor (ab120192), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Dynasore, dynamin inhibitor (ab120192)

    ab66705 staining PAI1 in HeLa cells treated with dynasore (ab120192), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of dynasore, as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120689 (dynasore) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

  • Western blot - Dynasore, dynamin inhibitor (ab120192), expandable thumbnail
    Jens H et al. PLoS One. 2016; 11(10): e0164768. doi: 10.1371/journal.pone.0164768 Reproduced under the Creative Commons license https://creativecommons.org/publicdomain/zero/1.0/

    Western blot - Dynasore, dynamin inhibitor (ab120192)

    Western blots of indicated proteins after knockdown with gene-specific siRNA against AP2M1 (ab120192) or non-targeting siRNA transfection control (NT).

    siRNAs were transfected into HMVEC-L at the concentration of 100 nM for 48h. The cells were then infected with ANDV (MOI = 0.5) for 24 h or 48 h. Western blots were performed post infection to ensure knockdown of the specific protein expression. The blots were also probed with β-actin specific antibody as the gel-loading control.

    Jens H et al. PLoS One. 2016; 11(10): e0164768. doi: 10.1371/journal.pone.0164768

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Product protocols

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