Dyngo® 4a, Novel, highly potent dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). Dynasore (ab120192) analog. Prevents botulin neurotoxin A (BoNTs) uptake and internalization, and prevents SNAP25 cleavage. Inhibits BoNTs-induced paralysis and delays botulism onset.
- Cited in over 75 publications
- Purity > 99%
- Soluble in DMSO to 100 mM
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- The Journal of pharmacology and experimental therapeutics 388:506-5172024Differential Efficacy of Small Molecules Dynasore and Mdivi-1 for the Treatment of Dry Eye Epitheliopathy or as a Countermeasure for Nitrogen Mustard Exposure of the Ocular Surface.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJinhong Pan,Satyabrata Pany,Rafael Martinez-Carrasco,M Elizabeth FiniPubMed 37442618
- Nature chemical biology :2023β-Arrestin-independent endosomal cAMP signaling by a polypeptide hormone GPCR.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmily E Blythe,Mark von ZastrowPubMed 37749347
- Advanced materials (Deerfield Beach, Fla.) 35:e23008122023Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSungwook Jung,Moufida Ben Nasr,Baharak Bahmani,Vera Usuelli,Jing Zhao,Gianmarco Sabiu,Andy Joe Seelam,Said Movahedi Naini,Hari Baskar Balasubramanian,Youngrong Park,Xiaofei Li,Salma Ayman Khalefa,Vivek Kasinath,MacKenzie D Williams,Ousama Rachid,Yousef Haik,George C Tsokos,Clive H Wasserfall,Mark A Atkinson,Jonathan S Bromberg,Wei Tao,Paolo Fiorina,Reza AbdiPubMed 37357903
- Histochemistry and cell biology 160:435-4522023Selective targeting of lectins and their macropinocytosis in urothelial tumours: translation from in vitro to ex vivo.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNataša Resnik,Tanja Višnjar,Tomaž Smrkolj,Mateja Erdani Kreft,Rok Romih,Daša ZupančičPubMed 37535087
- Scientific reports 13:74772023Fluorescence resonance energy transfer (FRET) spatiotemporal mapping of atypical P38 reveals an endosomal and cytosolic spatial bias.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJeremy C Burton,Jennifer Okalova,Neil J GrimseyPubMed 37156828
- Cell reports 42:1124782023Nanoscale and functional heterogeneity of the hippocampal extracellular space.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDiego Grassi,Agata Idziak,Antony Lee,Ivo Calaresu,Jean-Baptiste Sibarita,Laurent Cognet,U Valentin Nägerl,Laurent GrocPubMed 37149864
- Proceedings of the National Academy of Sciences of the United States of America 120:e22087491202023Soluble cyclase-mediated nuclear cAMP synthesis is sufficient for cell proliferation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAlejandro Pizzoni,Xuefeng Zhang,Nyla Naim,Daniel L AltschulerPubMed 36656863
- Cellular & molecular immunology 20:264-2762023The neuropeptide CGRP enters the macrophage cytosol to suppress the NLRP3 inflammasome during pulmonary infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFangrui Zhu,Dou Yu,Xiwen Qin,Yan Qian,Juan Ma,Weitao Li,Qiannv Liu,Chunlei Wang,Yan Zhang,Yi Li,Dong Jiang,Shuo Wang,Pengyan XiaPubMed 36600053
- Nature communications 14:342023Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMarie-Lise Jobin,Sana Siddig,Zsombor Koszegi,Yann Lanoiselée,Vladimir Khayenko,Titiwat Sungkaworn,Christian Werner,Kerstin Seier,Christin Misigaiski,Giovanna Mantovani,Markus Sauer,Hans M Maric,Davide CalebiroPubMed 36596803
- Life science alliance 6:2022CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJuan Carlos Polanco,Yevhen Akimov,Avinash Fernandes,Adam Briner,Gabriel Rhys Hand,Marloes van Roijen,Giuseppe Balistreri,Jürgen GötzPubMed 36316035
Key facts
- CAS number
- 1256493-34-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 338.3 Da
- Molecular formula
- C18H14N2O5
- PubChem identifier
- 136227923
- Nature
- Synthetic
Target data
Recommended products
Dyngo® 4a, Novel, highly potent dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). Dynasore (ab120192) analog. Prevents botulin neurotoxin A (BoNTs) uptake and internalization, and prevents SNAP25 cleavage. Inhibits BoNTs-induced paralysis and delays botulism onset.
- Cited in over 75 publications
- Purity > 99%
- Soluble in DMSO to 100 mM
Key facts
- CAS number
- 1256493-34-1
- Purity
- > 99%
- Form
- Solid
- Molecular weight
- 338.3 Da
- Molecular formula
- C18H14N2O5
- PubChem identifier
- 136227923
- Nature
- Synthetic
- Solubility
Soluble in DMSO to 100 mM.
- Biochemical name
- Dyngo-4a
- Biological description
Novel, highly potent dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). Dynasore (ab120192) analog. Prevents botulin neurotoxin A (BoNTs) uptake and internalization, and prevents SNAP25 cleavage. Inhibits BoNTs induced paralysis and delays botulism onset.
- Canonical SMILES
- C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3O)O)O)O
- Isomeric SMILES
- C1=CC=C2C=C(C(=CC2=C1)C(=O)N/N=C/C3=CC(=C(C=C3O)O)O)O
- InChI
- InChI=1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+
- InChIKey
- UAXHPUSKEWEOAP-DJKKODMXSA-N
- IUPAC name
- 3-hydroxy-N-[(E)-(2,4,5-trihydroxyphenyl)methylideneamino]naphthalene-2-carboxamide
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
- Storage information
- Store under desiccating conditions, The product can be stored for up to 12 months
Notes
Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dyngo® is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.
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3 product images
Immunocytochemistry/ Immunofluorescence - Dyngo® 4a, Novel, highly potent dynamin inhibitor (ab120689)
Anti-PAI1 antibody ab66705 staining PAI1 in HeLa cells treated with dyngo-4a™(ab120689), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of dyngo-4a™, as described in literature.
The cells were incubated at 37°C for 6h in media containing different concentrations of ab120689 (dyngo-4a™) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with Anti-PAI1 antibody ab66705 (5 μg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (Goat Anti-Rabbit IgG H&L (DyLight® 488) preadsorbed ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Chemical Structure - Dyngo® 4a, Novel, highly potent dynamin inhibitor (ab120689)
2D chemical structure image of ab120689, Dyngo® 4a, Novel, highly potentdynamin inhibitor
Kockx M et al. PLoS One. 2014; 9(10): e111186. doi: 10.1371/journal.pone.0111186 Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/Functional Studies - Dyngo® 4a, Novel, highly potent dynamin inhibitor (ab120689)
Primary human monocyte-derived macrophages were treated without (Ctrl) and with ab120689 (Dyngo 4A) for 2 h. Effects on α-tubulin and acetylated tubulin (Ac-tubulin) were determined by confocal microscopy.
Credit: Kockx M et al. PLoS One. 2014; 9(10): e111186. doi: 10.1371/journal.pone.0111186
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