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AB141290

Dynole® 2-24, Dynamin I and II inhibitor

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(1 Publication)

MW 371.6 Da, Purity >97%. Novel, potent dynamin I and II inhibitor (IC50 values are 0.56 and 5.4 μM respectively). Shows 4.4-fold selectivity for dynamin I. Highly potent inhibitor of clathrin mediated endocytosis (IC50 = 1.9 μM). Displays low cell toxicity.
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Chemical Structure - Dynole® 2-24, Dynamin I and II inhibitor (AB141290)
  • Chemical Structure

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Chemical Structure - Dynole® 2-24, Dynamin I and II inhibitor (AB141290)

2D chemical structure image of ab141290, Dynole® 2-24, Dynamin I and II inhibitor

Key facts

CAS number

1416313-72-8

Purity

>97%

Form

Liquid

form

Molecular weight

371.6 Da

Molecular formula

C<sub>2</sub><sub>4</sub>H<sub>4</sub><sub>1</sub>N<sub>3</sub>

PubChem

71546959

Nature

Synthetic

Biochemical name

Dynole 2-24

Biological description

Novel, potent dynamin I and II inhibitor (IC50 values are 0.56 and 5.4 μM respectively). Shows 4.4-fold selectivity for dynamin I. Highly potent inhibitor of clathrin mediated endocytosis (IC50 = 1.9 μM). Displays low cell toxicity.

Canonical smiles

CCCCCCCCCCNCC1=CN(C2=CC=CC=C21)CCCN(C)C

InChi

InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3

IUPAC Name

N-[[1-[3-(dimethylamino)propyl]indol-3-yl]methyl]decan-1-amine

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Product details

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dynole® is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Storage information
Store under desiccating conditions
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Product protocols

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 6: PubMed29271742

2017

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Ya Chang,Chen Chen,Min Lee,Ya-Chu Chang,Chi-Huan Lu,Shao-Tzu Lu,De-Yao Wang,Aijun Wang,Chin-Lin Guo,Pei-Lin Cheng
View all publications
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Biochemicals

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