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MW 338.45 g/mol, Purity >97%.

Negative control molecule for use with Dynole® 34-2 ab120463. Displays no significant activity at dynamin I or II (up to 300 µM).

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Key facts

Purity

> 97%

Form

Solid

Molecular weight

338.45 g/mol

Nature

Synthetic

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MW 338.45 g/mol, Purity >97%.

Negative control molecule for use with Dynole® 34-2 ab120463. Displays no significant activity at dynamin I or II (up to 300 µM).

.

Key facts

Purity

> 97%

Biological description

Negative control molecule for use with Dynole® 34-2 ab120463. Displays no significant activity at dynamin I or II (up to 300 µM).

Canonical SMILES

CCCNC(=O)C(C#N)=CC2CN(CCCN(C)C)C1CCCCC12

InChI

InChI=1S/C20H26N4O/c1-4-10-22-20(25)16(14-21)13-17-15-24(12-7-11-23(2)3)19-9-6-5-8-18(17)19/h5-6,8-9,13,15H,4,7,10-12H2,1-3H3,(H,22,25)/b16-13+

InChIKey

NOOFIXCUBMYDIB-DTQAZKPQSA-N

IUPAC name

2-Cyano-N-propyl-3-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]acrylamide

Storage

Shipped at conditions

Ambient - Can Ship with Ice

Appropriate long-term storage conditions

+4°C

Storage information

Store under desiccating conditions, The product can be stored for up to 12 months

Notes

Sold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dynole® is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.

Product promise

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Full details and terms and conditions can be found here:
Terms & Conditions.

3 product images

  • Chemical Structure - Dynole® 31-2, Negative control for Dynolereg 34-2 (ab120464), expandable thumbnail

    Chemical Structure - Dynole® 31-2, Negative control for Dynolereg 34-2 (ab120464)

    2D chemical structure image of ab120464, Dynole® 31-2, Negative control for Dynolereg 34-2

  • Immunocytochemistry/ Immunofluorescence - Dynole® 31-2, Negative control for Dynolereg 34-2 (ab120464), expandable thumbnail

    Immunocytochemistry/ Immunofluorescence - Dynole® 31-2, Negative control for Dynolereg 34-2 (ab120464)

    ab66705 staining PAI1 in HeLa cells treated with dynole-31-2™ (ab120464), by ICC/IF. No change in PAI1 expression with increased concentration of dynole-31-2™ (negative control for dynole 34-2™ (ab120463), as described in literature.
    The cells were incubated at 37°C for 6h in media containing different concentrations of ab120464 (dynole-31-2™) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

  • Functional Studies - Dynole® 31-2, Negative control for Dynolereg 34-2 (ab120464), expandable thumbnail
    Eppler et al PLoS One. 2017; 12(3): e0172443. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    Functional Studies - Dynole® 31-2, Negative control for Dynolereg 34-2 (ab120464)

    Dynamin2 regulates integrin-mediated T lymphocyte adhesion under laminar flow.

    End point quantification of T lymphocyte adhesion following treatment of the cells with either Dynole 31–2 as a control or Dynole 34–2 to inhibit dynamin2 activity (n = 6)

    (From Figure 2D of Eppler et al).

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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